A5042296886- Heme Oxygenase-1 and Carbon Monoxide
- Adipose Tissue and Metabolism
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Mesenchymal stem cell research
- Hemoglobin structure and function
- Neonatal Health and Biochemistry
- Acute Myeloid Leukemia Research
- Birth, Development, and Health
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Metabolism, Diabetes, and Cancer
- Pregnancy and preeclampsia studies
- Kruppel-like factors research
- Eosinophilic Disorders and Syndromes
- Phytochemicals and Antioxidant Activities
- Endoplasmic Reticulum Stress and Disease
- Mangiferin and Mango Extracts
- Blood properties and coagulation
- Liver physiology and pathology
- Ubiquitin and proteasome pathways
University of Catania
2015-2024
University of Turin
2021
University of Chieti-Pescara
2021
Istituto Euro Mediterraneo di Scienza e Tecnologia
2014-2016
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2015
New York Medical College
2012
Rockefeller University
2012
University of Toledo
2012
Chinese PLA General Hospital
2012
University of Brescia
2012
Liraglutide is a glucagon-like peptide-1 analog and glucose-lowering agent whose effects on cardiovascular risk markers have not been fully elucidated.
Nicotinamide adenine dinucleotide (NAD⁺) homeostasis is emerging as a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and tightly linked to SIRT1/5'-AMP-activated protein kinase (AMPK) pathway. Silibinin, main component silymarin, has been proposed nutraceutical for treatment NAFLD. In this study, we aimed identify whether silibinin may influence NAD⁺/SIRT1 axis. To end, C57BL/6 mice were fed high fat diet (HFD) 16 weeks, treated with or vehicle during last 8...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by the ac-cumulation of fat in hepatocytes without alcohol consumption. Mitochondrial dysfunction and endoplasmic reticulum (ER) stress play significant roles NAFLD pathogenesis. The unfolded protein response mitochondria (UPRmt) an adaptive mechanism that aims to restore mitochondrial homeostasis mitigate cellular stress. This study aimed investigate effects ( +)-Lipoic acid (ALA) on UPRmt,...
We examined the hypothesis that adipocyte dysfunction in mice fed a high-fat (HF) diet can be prevented by lentiviral-mediated and specific-targeting delivery of human heme oxygenase-1 (aP2-HO-1). A bolus intracardial injection aP2-HO-1 resulted expression HO-1 for up to 9.5 months. Transduction increased fat tissues without affecting murine HO-1. In HF diet, transduction attenuated increases body weight, blood glucose, pressure, inflammatory cytokines, as well content both visceral...
Several natural antioxidants, including ellagic acid (EA), have been reported to chemotherapeutic activity in vivo and vitro settings. Cytochrome P450 (CYP) synthesis of both epoxyeicosatrienoic acids (EETs) 20-hydroxy-5,8,11,14-eicosatetraenoic (20-HETE), together with vascular endothelial growth factor (VEGF) heme oxygenase system (HO) emerged as important modulators tumor metastasis.The anti-angiogenic effects EA were investigated the human prostatic cancer cell line LnCap. HO-1, HO-2,...
Identification of imatinib mesylate as a potent inhibitor the Abl kinase and subsequent findings that this compound displays growth inhibitory pro-apoptotic effects in Bcr-Abl+ cells, has deeply conditioned CML treatment. Unfortunately initial striking efficacy drug been overshadowed by development clinical resistance. A wide variety molecular mechanisms can underlie such resistance mechanisms. In recent years, heme oxygenase-1 (HO-1) expression reported an important protective endogenous...
Tumor immune tolerance can derive from the recruitment of suppressor cell population, including myeloid derived cells (MDSCs), able to inhibit T activity. We identified a significantly expanded MDSCs population in chronic leukemia (CML) patients at diagnosis that decreased normal levels after imatinib therapy. In addition, expression arginase 1 (Arg1) depletes microenvironment arginine, an essential aminoacid for function, resulted increase diagnosis. Purified CML CD11b+CD33+CD14-HLADR-...
We have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on vascular function; in addition to its antiapoptotic action, it increases insulin sensitivity and inhibits inflammation. To uncover the signaling mechanisms by which EET reduces cardiomyopathy, we hypothesized infusion might ameliorate obesity-induced cardiomyopathy improving heme oxygenase (HO)-1, Wnt1, thermogenic gene levels, mitochondrial integrity cardiac tissues improved pericardial fat...
// Daniele Tibullo 1, 3, * , Ignazio Barbagallo 2, Cesarina Giallongo 1 Luca Vanella 2 Concetta Conticello Alessandra Romano Salvatore Saccone 3 Justyna Godos Francesco Di Raimondo Giovanni Li Volti 4, 5 Division of Haematology, AOU “Policlinico - Vittorio Emanuele”, University Catania, Italy Department Drug Sciences, Biological, Geological and Environmental 4 Biomedical Biotechnological EuroMediterranean Institute Science Technology, Palermo, These authors have contributed...
Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), for this reason, both are very difficult treat. Therefore, novel antimicrobial chemotherapic drugs needed effective antibiotic therapy. The aim of the present study was assess anti-proliferative effects skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758). Our results showed that exhibited a significant specific antibacterial activity against Gram-negative bacteria but not Gram-positive bacteria....
Uveal melanoma (UM), the most common primary intraocular cancer in adults, is among tumors with poorer prognosis. Recently, role of oncometabolite lactate has become attractive due to its as hydroxycarboxylic acid receptor 1 (HCAR1) activator, an epigenetic modulator inducing lysine residues lactylation and, course, a glycolysis end-product, bridging gap between and oxidative phosphorylation. The aim present study was dissect UM cell line (92.1) either metabolite or signaling molecule, using...