A5086602723- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Antioxidant Activity and Oxidative Stress
- Free Radicals and Antioxidants
- Natural Antidiabetic Agents Studies
- Bee Products Chemical Analysis
- Adipose Tissue and Metabolism
- Infectious Diseases and Tuberculosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Eicosanoids and Hypertension Pharmacology
- Electron Spin Resonance Studies
- Lipid Membrane Structure and Behavior
- Radiation Therapy and Dosimetry
- Medicinal Plants and Bioactive Compounds
- Diagnosis and treatment of tuberculosis
- Moringa oleifera research and applications
- Cardiac Ischemia and Reperfusion
- Plant chemical constituents analysis
- Alcohol Consumption and Health Effects
- Berberine and alkaloids research
- Advancements in Transdermal Drug Delivery
University of Catania
2016-2025
University of Palermo
2024-2025
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud
2021
Marymount University
2008
Betula etnensis Raf. (Birch Etna) belonging to the Betulaceae family grows on eastern slope of Etna. Many bioactive compounds present in species are considered promising anticancer agents. In this study, we evaluated effects B. bark methanolic extract a human colon cancer cell line (CaCo2). order elucidate mechanisms action extract, cellular redox status, cycle, and heme oxygenase-1 (HO-1) expression ferroptosis induction were evaluated. Cell viability proliferation tested by tetrazolium...
This study aims at investigating the contribution of two classes compounds, flavonoids and iridoids, to bioactivity Arbutus unedo L. leaves fruits. The impact different extraction procedures on phytochemicals content hypoglycemic, antioxidant, nitric oxide (NO) inhibitory activities A. fresh dried plant materials was investigated. Ellagic acid 4-O-β-D-glucopyranoside, kaempferol 3-O-glucoside, norbergenin were identified for first time in this genus by using liquid...
The normal-weight obese (NWO) syndrome was identified in women whose body weight (BW) and BMI are normal but fat mass (FM) is >30%. In these subjects, an early inflammatory status has been demonstrated. aim to verify whether oxidative stress occurs NWO. Sixty age-matched white Italian were studied subdivided as follows: 20 individuals (NW) (BMI <25 kg/m(2); FM% <30%); NWO >30%); preobese-obese (OB) >25 >30%). Anthropometric, composition (by dual-energy X-ray absorptiometry) variables, plasma...
Context: Solid lipid nanoparticles (SLN) are regarded as interesting drug delivery systems and their preparation techniques have gained a great deal of attention.Objective: To evaluate the feasibility preparing idebenone (IDE) loaded SLN from O/W microemulsions by phase-inversion temperature (PIT) method. Since been proposed to improve brain, IDE was chosen model due its activity in treatment neurodegenerative diseases.Materials Methods: Cetyl palmitate used solid prepare containing two...
Several natural antioxidants, including ellagic acid (EA), have been reported to chemotherapeutic activity in vivo and vitro settings. Cytochrome P450 (CYP) synthesis of both epoxyeicosatrienoic acids (EETs) 20-hydroxy-5,8,11,14-eicosatetraenoic (20-HETE), together with vascular endothelial growth factor (VEGF) heme oxygenase system (HO) emerged as important modulators tumor metastasis.The anti-angiogenic effects EA were investigated the human prostatic cancer cell line LnCap. HO-1, HO-2,...
Several natural antioxidants, including anthocyanins, have been reported to chemotherapeutic activity in vivo and vitro. The aim of the present study was delineate anti-proliferative cytodifferentiation properties mediated by cyanidin-3-O-β-glucopyranoside (C3G) treatment DU145 LnCap human prostatic cancer cell lines. C3G produced effects through activation caspase-3 induction p21 protein expression. reduced viability associated with a clear increase DNA fragmentation both lines after...
Background The concentration of peroxynitrite in the brain increases after central nervous system injuries. authors hypothesized that propofol, because its particular chemical structure, mitigates effects peroxynitrite-mediated oxidative stress and apoptosis by induction heme oxygenase (HO)-1 primary cultured astroglial cells. Methods Primary cells were incubated for 18 h with a known donor (3 mm SIN-1) presence or absence propofol (40 microm, 80 160 1 mm). protective evaluated...
Several medicinal foods abound in traditional medicine with antioxidant potentials that could be of importance for the management several diseases but little or no scientific justification to substantiate their use. Thus, objective this study was assessment effect two leave extracts Solanum nigrum L. (SN), which is a plant member Solanaceae family, mainly used soup preparation different parts world. Then methanolic/water (80:20) (SN1) and water (SN2) leaves were prepared. The total...
Gastrointestinal cancers, particularly colorectal cancer, are mainly influenced by the dietary factor. A diet rich in fruits and vegetables can help to reduce incidence of cancer thanks phenolic compounds, which possess antimutagenic anticarcinogenic properties. Polyphenols, alongside their well-known antioxidant properties, also show a pro-oxidative potential, makes it possible sensitize tumor cells oxidative stress. HO-1 combined with activity, when overexpressed cells, is involved...
In Europe, Paeonia officinalis and P. peregrina, along with Chinese lactiflora, are commonly used for medicinal purposes. This comprehensive review summarizes the secondary metabolites biological activities of officinalis, tenuifolia, mascula, ornamental cultivars derived from last taxon. Terpenoids, flavonoids, phenolic acids present in all five species, while tannins, lipids, organic have been identified only some. All species exhibit antioxidant antimicrobial potential, alongside...