A5059844704- Blood properties and coagulation
- Biochemical effects in animals
- Heme Oxygenase-1 and Carbon Monoxide
- Advancements in Transdermal Drug Delivery
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Erythrocyte Function and Pathophysiology
- Eicosanoids and Hypertension Pharmacology
- Lipid Membrane Structure and Behavior
- Phytochemicals and Antioxidant Activities
- Immunotoxicology and immune responses
- Click Chemistry and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Berberine and alkaloids research
- Tendon Structure and Treatment
- Free Radicals and Antioxidants
- Vitamin C and Antioxidants Research
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Receptor Mechanisms and Effects
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Genomics, phytochemicals, and oxidative stress
- Coenzyme Q10 studies and effects
- Antioxidant Activity and Oxidative Stress
- Neuropeptides and Animal Physiology
University of Catania
2014-2024
Istituto di Farmacologia Traslazionale
2019
University of Brescia
2007
Marche Polytechnic University
2005
Marymount University
2004
Context: Solid lipid nanoparticles (SLN) are regarded as interesting drug delivery systems and their preparation techniques have gained a great deal of attention.Objective: To evaluate the feasibility preparing idebenone (IDE) loaded SLN from O/W microemulsions by phase-inversion temperature (PIT) method. Since been proposed to improve brain, IDE was chosen model due its activity in treatment neurodegenerative diseases.Materials Methods: Cetyl palmitate used solid prepare containing two...
Background The concentration of peroxynitrite in the brain increases after central nervous system injuries. authors hypothesized that propofol, because its particular chemical structure, mitigates effects peroxynitrite-mediated oxidative stress and apoptosis by induction heme oxygenase (HO)-1 primary cultured astroglial cells. Methods Primary cells were incubated for 18 h with a known donor (3 mm SIN-1) presence or absence propofol (40 microm, 80 160 1 mm). protective evaluated...
Several medicinal foods abound in traditional medicine with antioxidant potentials that could be of importance for the management several diseases but little or no scientific justification to substantiate their use. Thus, objective this study was assessment effect two leave extracts Solanum nigrum L. (SN), which is a plant member Solanaceae family, mainly used soup preparation different parts world. Then methanolic/water (80:20) (SN1) and water (SN2) leaves were prepared. The total...
Alzheimer's disease (AD) is a neurodegenerative representing the most prevalent cause of dementia. It also related to aberrant amyloid-beta (Aβ) protein deposition in brain. Since oxidative stress involved AD, there possible role antioxidants present effected person's diet. Thus, we assessed effect systemic administration solid lipid nanoparticles (SLNs) facilitate curcumin (CUR) delivery on TG2 isoform expression levels Wild Type (WT) and TgCRND8 (Tg) mice. An experimental model which...
The aim of this study was to evaluate the involvement oxidative stress in glutamate-evoked transglutaminase (TGase) upregulation astrocyte cultures (14 DIV). A 24 h exposure glutamate caused a dose-dependent depletion glutathione intracellular content and increased ROS production cell cultures. These effects were receptor-mediated, as demonstrated by inhibition with GYKI 52466. pre-incubation ethyl ester or cysteamine recovered status effective significantly reducing glutamate-increased...
The mechanisms involved in endothelial dysfunction are multifactorial. A correlation between oxidative stress and derangements of nitric oxide synthase (NOS) pathways altered homeostasis has been most studied demonstrated different pathophysiological conditions. NOS activities regulated by endogenous inhibitors such as asymmetric dimethyl-L-arginine (ADMA) that is metabolized dimethylarginine dimethylaminohydrolase (DDAH). Since recent data some may be related to reduced expression and/or...
The aim of the present research was to investigate effect cyanidin-3-O-beta-glucoside (C3G) on heme oxygenase-1 (HO-1), endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS) and dimethylarginine dimethylamino hydrolase-2 (DDAH-2) expression in cultured cells. Different concentrations (0.00625-250 microM) C3G were tested order possible beneficial harmful effects C3G. Our data demonstrated that increased induction eNOS HO-1 a dose-dependent manner. Higher concentration (62.5-250 also...
Although the precise role of transglutaminase in cell death is unknown, several findings demonstrate that tissue selectively accumulates cells undergoing apoptosis both vivo and vitro. Calcium-dependent reactions are also implicated neurodegenerative diseases, including alterations release excitatory amino acids. One prevalent theme damage induced by excitotoxic stimuli different regions CNS may be executed intracellular caspase proteases. Furthermore, presence functional ion channel-gated...