A5019565420- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Cholesterol and Lipid Metabolism
- Edible Oils Quality and Analysis
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disorders and Treatments
- Nerve injury and regeneration
- Medicinal Plants and Neuroprotection
- Computational Drug Discovery Methods
- Pain Mechanisms and Treatments
- Andrographolide Research and Applications
- Mitochondrial Function and Pathology
- Advanced Drug Delivery Systems
- Nuclear Receptors and Signaling
- Biochemical effects in animals
- Inflammatory mediators and NSAID effects
- Phagocytosis and Immune Regulation
University of Florence
2014-2023
Health and Human Development (2HD) Research Network
2013
University of Cambridge
2006
The claimed beneficial effects of the Mediterranean diet include prevention several age-related dysfunctions including neurodegenerative diseases and Alzheimer-like pathology. These have been related to protection against cognitive decline associated with aging disease by a number polyphenols found in red wine extra virgin olive oil. double transgenic TgCRND8 mice (overexpressing Swedish Indiana mutations human amyloid precursor protein), aged 1.5 4, age-matched wild type control were used...
More than 40 human diseases are associated with fibrillar deposits of specific peptides or proteins in tissue. Amyloid fibrils, their precursors, can be highly toxic to cells, suggesting key role disease pathogenesis. Proteins not any able form oligomers and amyloid assemblies vitro displaying structures cytotoxicity comparable those aggregates disease-related polypeptides. In isolated such toxicity has been shown result from increased membrane permeability disruption ion homeostasis...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive functions, extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles within neocortex hippocampus. Adult hippocampal neurogenesis plays an important role in learning memory processes its abnormal regulation might account for impairments associated with AD.The double transgenic (Tg) CRND8 mice (overexpressing the Swedish Indiana mutations human amyloid...
To investigate the role of Wnt inhibitor Dickkopf-1 (DKK-1) in pathophysiology neurodegenerative diseases, we analysed DKK-1 expression and localization transgenic mouse models expressing familial Alzheimer's disease mutations a frontotemporal dementia mutation. A significant increase was found diseased brain areas all lines, where it co-localized with hyperphosphorylated tau-bearing neurons. In TgCRND8 mice, immunoreactivity detected neurons surrounding amyloid deposits within choline...
// Stefania Rigacci 1,* , Caterina Miceli Chiara Nediani 1 Andrea Berti Roberta Cascella Daniela Pantano 2 Pamela Nardiello Ilaria Luccarini Fiorella Casamenti and Massimo Stefani Department of Experimental Clinical Biomedical Sciences, Division Pharmacology Toxicology, University Florence, Italy Neuroscience, Psychology, Drug Research Child Health, * These authors have contributed equally to the work Correspondence to: Nediani, email: Keywords : oleuropein aglycone, autophagy,...
Clioquinol (CQ) is a "metal protein attenuating compound" that crosses the blood-brain barrier and binds, with high affinity, copper(II) zinc(II), two metal ions critically involved in amyloid-β aggregation toxicity. CQ was recently proposed