A5066886963- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Synthesis and pharmacology of benzodiazepine derivatives
- Analytical Chemistry and Chromatography
- Pain Mechanisms and Treatments
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Ion channel regulation and function
- Neurological disorders and treatments
- Epilepsy research and treatment
- Analytical Methods in Pharmaceuticals
- Crystallization and Solubility Studies
- Parkinson's Disease Mechanisms and Treatments
- Advanced Drug Delivery Systems
- Phenothiazines and Benzothiazines Synthesis and Activities
- Computational Drug Discovery Methods
- Chemical Synthesis and Analysis
- Advancements in Transdermal Drug Delivery
- Environmental Toxicology and Ecotoxicology
- Neuropeptides and Animal Physiology
- Quinazolinone synthesis and applications
- Pharmacological Receptor Mechanisms and Effects
- Phytochemical Studies and Bioactivities
- Mercury impact and mitigation studies
- Cancer, Stress, Anesthesia, and Immune Response
University of Catania
1990-2022
Magna Graecia University
1999-2010
University of Modena and Reggio Emilia
2003-2004
University of Pavia
1999-2003
University of Siena
2003
University of Messina
2001
National Research Council
1999
University of Reggio Calabria
1995-1998
University of Palermo
1995
Several medicinal foods abound in traditional medicine with antioxidant potentials that could be of importance for the management several diseases but little or no scientific justification to substantiate their use. Thus, objective this study was assessment effect two leave extracts Solanum nigrum L. (SN), which is a plant member Solanaceae family, mainly used soup preparation different parts world. Then methanolic/water (80:20) (SN1) and water (SN2) leaves were prepared. The total...
Novel AT1 receptor antagonists bearing substituted 4-phenylquinoline moieties instead of the classical biphenyl fragment were designed and synthesized as first step an investigation devoted to development new antihypertensive agents understanding molecular basis their pharmacodynamic pharmacokinetic properties. The newly compounds tested for potential ability displace [125I]Sar1,Ile8-Ang II specifically bound in rat hepatic membranes. These binding studies revealed nanomolar affinity several...
Abstract The clinical relevance of a long‐duration response (LDR) to levodopa therapy in Parkinson's disease (PD) has not been widely recognized. In 25 patients with moderate PD, we measured LDR on motor function after short periods treatment (subacute tests). Each subacute test lasted 15 days and consisted the oral administration at various interdose intervals (IDIs) 48, 24, 12, 8, 6, 5 hours. goal for was achieve satisfactory antiparkinsonian effect before last dose (day 15), i.e., an...
The long-duration response (LDR) to chronic levodopa treatment may mask the short-duration (SDR) a single dose of drug in Parkinson's disease (PD). As result, measurement SDR be inaccurate for establishing dosing regimen individual patients. To evaluate possible contamination by LDR, we investigated 16 patients with PD characteristics administered after prolonged washout from therapy and 15-day period levodopa. Levodopa produced sustained SDR, measured on 15th day treatment, had lower...
<b><i>Objective:</i></b> To determine the modifications of long-duration response to levodopa in PD over a 1-year period. <b><i>Background:</i></b> The development predictable motor fluctuations has been attributed mainly time short-duration levodopa, whereas role not widely investigated. <b><i>Methods:</i></b> In 17 patients with authors examined prospectively both and under standardized conditions on two different occasions separated by period approximately 1 year (11.7 ± 3.6 months)....
Abstract Objectives The purpose of this study was the evaluation antioxidant activity natural and semisynthetic polyphenol derivatives from Olea europea L., by assessing malondialdehyde (MDA), an important marker oxidative stress. Methods Polyphenol as hydroxytyrosol, oleuropein, oleuropein aglycone mix four tautomeric forms their respective acetyl-derivatives were obtained olive leaves using protocols. These compounds administered intraperitoneally to Wistar rats treated with paraquat,...
In clinical practice, inflammatory pain is an important, unresolved health problem, despite the utilization of non-steroidal anti-inflammatory drugs (NSAIDs). last decade, different studies have proven that reactive oxygen species (ROS) and nitrogen (RNS) are involved in development maintenance hyperalgesia via post-translation modification key proteins, such as manganese superoxide dismutase (MnSOD). It well-known inducible cyclooxygenase 2 (COX-2) plays a crucial role at beginning response...
Regioisomeric 3-carboxyisoxazolinyl prolines [CIP-A (±)-6 and CIP-B (±)-7] 3-hydroxyisoxazolinyl [(±)-8 (±)-9] were synthesized assayed for glutamate receptor activity. The tests carried out in vitro by means of binding techniques, second messenger assays, the rat cortical wedge preparation. CIP-A showed a good affinity both 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) kainic (KAIN) receptors. These results confirmed slice model where displayed an EC50 value very close to...
A series of 2,3-benzodiazepine derivatives has been previously described as noncompetitive AMPA-type glutamate receptor antagonists potentially useful for treatment epilepsy. To further explore the structure−activity relationships AMPA antagonists, a 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones (6) was synthesized starting from corresponding bicyclic 1-aryl-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-ones (2, CFM). The new compounds were found to possess anticonvulsant...
The synthesis and biological evaluation of a series new derivatives 2-substituted 5-phenyl-1,4-benzodiazepines, structurally related to tifluadom (5), are reported. Chemical pharmacological studies on compounds 6 have been pursued with the aim expanding SAR data validating previously proposed model interaction this class κ-opioid receptor. described has reinvestigated in order obtain more direct synthetic procedure. To study relationship between stereochemistry receptor binding affinity, 6e...
AbstractThe well known antiepileptic valproic acid (1) due to the long treatment of epilepsy may induce many adverse side effects on various systems. To minimize unwanted toxic by kinetic control drug release, 1 was physically entrapped into white beeswax microspheres using meltable dispersion process utilizing wetting agents. Solid, discrete, reproducible free flowing were obtained converting liquid droplets solid material. The average content 17% w/w. More than 95% isolated particle size...