A5021109233- Insect and Pesticide Research
- Neuroscience and Neuropharmacology Research
- Insect Pest Control Strategies
- Bee Products Chemical Analysis
- Nitric Oxide and Endothelin Effects
- Essential Oils and Antimicrobial Activity
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Plant and animal studies
- Helminth infection and control
- Liver Disease Diagnosis and Treatment
- Ion channel regulation and function
- Biochemical effects in animals
- Sirtuins and Resveratrol in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Paraoxonase enzyme and polymorphisms
- Medicinal Plants and Neuroprotection
- Cynara cardunculus studies
- Antioxidant Activity and Oxidative Stress
- Eicosanoids and Hypertension Pharmacology
- Epilepsy research and treatment
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Magna Graecia University
2016-2025
Department of Medical Sciences
2025
UCLouvain Saint-Louis Brussels
2022
IRCCS Ospedale San Raffaele
2021
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021
Sapienza University of Rome
2008
Azienda Ospedaliero Universitario Mater Domini
2000
University of Reggio Calabria
1997
University of Rome Tor Vergata
1995-1996
Antimicrobial resistance is an increasingly widespread phenomenon that of particular concern because the possible consequences in years to come. The dynamics leading microbial strains are diverse, but certainly include incorrect use veterinary drugs both terms dosage and timing administration. Moreover, drug often administered absence a diagnosis. Many active ingredients pharmaceutical formulations are, therefore, losing their efficacy. In this situation, it imperative seek alternative...
Background: The use of biopolymers is increasing in drug delivery, thanks to the peculiar properties these compounds such as their biodegradability, availability, and possibility modulating physico-chemical characteristics. In particular, protein-based systems albumin are able interact with many active compounds, biopharmaceutical properties. Zein a protein 20–40 kDa made up hydrophobic amino acids, generally regarded safe (GRAS) used coating material. Methods: this investigation, zein was...
There is a need for continued drug development nonalcoholic steatohepatitis (NASH). Bergamot plant whose fruit juice enriched with flavonoids and phenolic compounds which improves dyslipidemia markers of systemic inflammation in patients Metabolic Syndrome. The aim this study was to perform preclinical "proof concept" polyphenolic formulation (BPF99) the treatment NASH. A disease reversal performed diet-induced animal model NAFLD (DIAMOND). Groups 8 weeks old mice were randomly assigned...
Alzheimer's disease (AD) is a major global health problem today and the most common form of dementia. AD characterized by formation β-amyloid (Aβ) plaques neurofibrillary clusters, leading to decreased brain acetylcholine levels in brain. Another mechanism underlying pathogenesis abnormal phosphorylation tau protein that accumulates at level aggregates, areas affected this pathological process are usually cholinergic neurons cortical, subcortical, hippocampal areas. These effects result...
Arterial hypertension represents a leading cause of cardiovascular morbidity and mortality worldwide, the identification effective solutions for treating early stages elevated blood pressure (BP) is still relevant issue risk prevention. The pathophysiological basis occurrence BP onset arterial have been widely studied in recent years. In addition, consistent progress development novel, powerful, antihypertensive drugs their appropriate applications controlling increased our potential...
Beekeeping provides products with nutraceutical and pharmaceutical characteristics. These are characterized by abundance of bioactive compounds. For different reasons, honey, royal jelly, propolis, venom, pollen beneficial to humans animals could be used as therapeutics. The pharmacological action these is related many their constituents. main components honey include oligosaccharides, methylglyoxal, jelly proteins (MRJPs), phenolics Royal contains jelleins, royalisin peptides, MRJPs,...
Oxidative stress induced post-translational protein modifications are associated with the development of inflammatory hypersensitivities. At least 90% cellular reactive oxygen species (ROS) produced in mitochondria, where mitochondrial antioxidant, manganese superoxide dismutase (MnSOD), is located. MnSOD's ability to reduce ROS enhanced by NAD+-dependent deacetylase sirtuin (SIRT3). SIRT3 can levels deacetylating MnSOD and enhancing its neutralize or transcription other oxidative...
Non-Alcoholic Fatty Liver Disease (NAFLD) represents a risk factor for cardiovascular diseases. NAFLD is worsened by the simultaneous occurrence of type 2 diabetes mellitus (T2DM) causing an enhancement inflammatory and fibrotic processes. Although insulin resistance appears link between T2DM, current pharmacological treatments T2DM failed to produce relevant benefits in preventing T2DM-related liver dysfunction. In this randomized, double blind, placebo-controlled clinical study, we...
Neuropathic pain is a chronic painful disease. Data have shown that reactive oxygen species (ROS) are implicated in pain. Particularly, the enhanced ROS production alters mitochondrial genome and proteome through accumulation of lipid peroxidation products, such as 4-hydroxynonenal (4-HNE) malondialdehyde (MDA). Sirtuin 3 (SIRT3) protein its activity can reduce levels by modulating key antioxidant enzymes, manganese superoxide dismutase (MnSOD). Here, we evaluated role SIRT3 maintenance...