A5065473672- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Advanced Drug Delivery Systems
- Laser-Plasma Interactions and Diagnostics
- Antioxidant Activity and Oxidative Stress
- Sirtuins and Resveratrol in Medicine
- Environmental Toxicology and Ecotoxicology
- Free Radicals and Antioxidants
- RNA Interference and Gene Delivery
- Exercise and Physiological Responses
- High-pressure geophysics and materials
- Neuropeptides and Animal Physiology
- Essential Oils and Antimicrobial Activity
- Laser-Matter Interactions and Applications
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Laser-induced spectroscopy and plasma
- Nerve injury and regeneration
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Nuclear Receptors and Signaling
- RNA modifications and cancer
- Radiation Therapy and Dosimetry
University of Catania
2016-2025
Université Paris Cité
2020
Centre National de la Recherche Scientifique
2020
Università di Camerino
2013
Uveal melanoma (UM) represents the most frequent primary tumor of eye. Despite development new drugs and screening programs, prognosis patients with UM remains poor no effective prognostic biomarkers are yet able to identify high‑risk patients. Therefore, in present study, microRNA (miRNA or miR) expression data, contained TCGA (UVM) database, were analyzed order a set miRNAs significance be used as clinical practice. Patients stratified into 2 groups, including stage (high‑grade vs....
Betula etnensis Raf. (Birch Etna) belonging to the Betulaceae family grows on eastern slope of Etna. Many bioactive compounds present in species are considered promising anticancer agents. In this study, we evaluated effects B. bark methanolic extract a human colon cancer cell line (CaCo2). order elucidate mechanisms action extract, cellular redox status, cycle, and heme oxygenase-1 (HO-1) expression ferroptosis induction were evaluated. Cell viability proliferation tested by tetrazolium...
This study investigated the DNA damage and apoptosis in colon cancer cells HCT-116 Caco-2 induced by engineered titanium dioxide nanoparticles (TiO2-NPs) (60 nm) food additive E171. MTT assays showed that both chemical forms significantly reduced cell viability a dose-dependent manner. In particular E171 pronounced inhibitory effect on growth of lines (E171 IC50: 3.45 mg/L for HTC-116 1.88 Caco-2; TiO2-NPs 60 nm 41.1 14.3 Caco-2). A low level genotoxicity was observed cells, especially when...
Introduction: The oncogenic transformation is driven by genetic and epigenetic alterations influencing cancer cell fate. These also result in metabolic reprogramming modulating the expression of membrane Solute Carrier (SLC) transporters involved biomolecules trafficking. SLCs act as tumor suppressors or promoters methylome, growth, immune-escape, chemoresistance. Methods: This silico study aimed to identify deregulated various types compared normal tissues analyzing TCGA Target GTEx...
Anthocyanins are a class of flavonoids, widely spread throughout the plant kingdom, exhibiting important antioxidant and anti-inflammatory actions as well chemotherapeutic effects; nonetheless, little is known about molecular mechanisms by which these activities exerted. The present study aimed at investigating involved in effects induced both cyanidin-3-O-beta glucopyranoside (CY3G) its aglycon form, cyanidin chloride (CY), human colon cancer cells (CaCo2). effect on cell growth, reactive...
IL-6 pathway is abnormally hyperactivated in several cancers triggering tumor cell growth and immune system inhibition. Along with genomic mutation, the IL6 gene expression can be affected by DNA methylation, microRNAs, post-translational modifications. Computational analysis was performed on Cancer Genome Atlas (TCGA) datasets to explore role of IL6, IL6R, IL6ST, IL6R transmembrane isoform their epigenetic regulation different cancer types. significantly modulated 70% types, revealing...
Gastrointestinal cancers, particularly colorectal cancer, are mainly influenced by the dietary factor. A diet rich in fruits and vegetables can help to reduce incidence of cancer thanks phenolic compounds, which possess antimutagenic anticarcinogenic properties. Polyphenols, alongside their well-known antioxidant properties, also show a pro-oxidative potential, makes it possible sensitize tumor cells oxidative stress. HO-1 combined with activity, when overexpressed cells, is involved...
In recent years, hyaluronic acid (HA) and the natural tripeptide glycyl-l-histidyl-l-lysine (GHK), especially its copper(II) complex (GHK-Cu), individually have been shown to exert helpful properties for bone protection regeneration. However, they are not strong enough handle oxidative stress, hydrolytic attack, or environmental conditions. Being aware that conjugation chemistry has recently emerged as an appealing approach generating new molecular entities capable of preserving integrity...
Specific breast cancer (BC) subtypes are associated with bad prognoses due to the absence of successful treatment plans. The triple-negative (TNBC) subtype, estrogen (ER), progesterone (PR) and human epidermal growth factor-2 (HER2) negative receptor status, is a clinical challenge for oncologists, because its aggressiveness effective therapies. In addition, proton therapy (PT) represents an against both inaccessible area located or conventional radiotherapy (RT)-resistant cancers, becoming...
It is well recognized that functional foods rich in antioxidants and antiinflammation agents including polyphenols, probiotics/prebiotics, bioactive compounds have been found to positive effects on the aging process. In particular, fruits play an important role regular diet, promoting good health longevity. this study, we investigated biological properties of extract obtained from Mangifera indica L. leaves preclinical vitro models. Specifically, profile content compounds, antimicrobial...
Excessive exposure to solar radiation is associated with several deleterious effects on human skin. These vary from the occasional simple sunburn conditions resulting chronic such as skin aging and cancers. Secondary metabolites plant kingdom, including phenolic compounds, show relevant photoprotective activities. In this study, we evaluated potential activity of a phytocomplex derived three varieties red orange (Citrus sinensis (L.) Osbeck). We used an in vitro model photoaging two cell...
Neurotrophins are a family of growth factors that play key role in the development and regulation functioning central nervous system. Their use as drugs is made difficult by their poor stability, cellular permeability, side effects. Continuing our effort to peptides mimic neurotrophic factor (NGF), model protein, specifically N-terminus here we report on spectroscopic characterization resistance hydrolysis 14-membered cyclic peptide reproducing sequence (SSSHPIFHRGEFSV (c-NGF(1–14)). Far-UV...
Astrocytes are actively involved in brain development, mature CNS regulation, and plasticity. They play a critical role response to cerebral injuries toxicants through reaction known as “reactive gliosis,” which is characterized by specific structural functional features. A large amount of literature highlights the central astrocytes mediating methylmercury (MeHg) neurotoxicity. In fact, mercury major neurotoxic pollutant that continues arouse interest research because severe risk it poses...
Physical activity offers a paradoxical hormetic effect and health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite well-documented evidence implicating oxidative stress in breast cancer, association between benefits redox status has investigated survivors who participate dragon boating. The present study plasmatic systemic (SOS) involved two distinct physical training exercises. A total of 75 were allocated one three groups: Control...
Complementary and alternative medicines represent an interesting field of research on which worldwide academics are focusing many efforts. In particular, the possibility to exploit pharmaceutical technology strategies, such as nanoencapsulation, for delivery essential oils is emerging a promising strategy not only in Italy but also all over world. The aim this work was development nanostructured lipid carriers (NLC) (Lavandula, Mentha, Rosmarinus) by intranasal administration, topic Italian...