A5101805932- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- thermodynamics and calorimetric analyses
- Essential Oils and Antimicrobial Activity
- Analytical Chemistry and Chromatography
- Surfactants and Colloidal Systems
- Advanced Drug Delivery Systems
- Free Radicals and Antioxidants
- Photochemistry and Electron Transfer Studies
- Protein Interaction Studies and Fluorescence Analysis
- Nanoparticle-Based Drug Delivery
- Spectroscopy and Quantum Chemical Studies
- Sphingolipid Metabolism and Signaling
- Antioxidant Activity and Oxidative Stress
- RNA Interference and Gene Delivery
- Metal complexes synthesis and properties
- Photosynthetic Processes and Mechanisms
- DNA and Nucleic Acid Chemistry
- Computational Drug Discovery Methods
- Radiopharmaceutical Chemistry and Applications
- Electrostatics and Colloid Interactions
- Lanthanide and Transition Metal Complexes
- Bone health and treatments
- Drug Transport and Resistance Mechanisms
- Pesticide Exposure and Toxicity
University of Catania
2014-2024
Politecnico di Milano
2020
Istituto di Farmacologia Traslazionale
1995-2012
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2011
Creative Commons
2011
Ospedale Policlinico San Martino
2011
University of Messina
2007
University of Insubria
2006
Massachusetts Institute of Technology
2005
Institute for Chemical and Physical Processes
2005
In the present paper, we report antimicrobial efficacy of three monoterpenes [linalyl acetate, (+)menthol, and thymol] against gram-positive bacterium Staphylococcus aureus gram-negative Escherichia coli. For a better understanding their mechanisms action, capability these to damage biomembranes was evaluated by monitoring release, following exposure compounds under study, water-soluble fluorescent marker carboxyfluorescein from unilamellar vesicles with different lipidic compositions...
The present article reports the antimicrobial efficacy of four monoterpenes (thymol, carvacrol, p-cymene, and gamma-terpinene) against Gram-positive bacterium Staphylococcus aureus Gram-negative Escherichia coli. For a better understanding their mechanism action, damage caused by these on biomembranes was evaluated monitoring release, following exposure to compounds under study, water-soluble fluorescent marker carboxyfluorescein (CF) from large unilamellar vesicles (LUVs) with different...
To assess and compare the results of trifocal (two-level bone lengthening with compression at nonunion site) bifocal (one-level transport using Taylor Spatial Frame (TSF; Smith Nephew, Inc, Memphis, TN) for postinfectious segmental tibial defects.Retrospective study 12 patients atrophic nonunions. These were treated resection followed by TSF defects. All same surgeon (F.S.).Level I trauma center.Twelve consecutive defects between November 2004 September 2007.All a or technique along...
The effects of lipid composition and preparation conditions on the physicochemical technological properties gemcitabine-loaded liposomes, as well in vitro anti-tumoral activity various liposome formulations were investigated. Three investigated: DPPC/Chol/Oleic acid (8:3:1 molar ratio, liposomes A), DPPC/Chol/DPPS (6:3:1 B) DPPC/Chol/DSPE-MPEG C). Multilamellar prepared by using TLE, FAT DRV methods, while small unilamellar obtained extrusion through polycarbonate filters. Light scattering...
Bone metastases contribute to morbidity in patients with common cancers, and conventional therapy provides only palliation can induce systemic side effects. The development of nanostructured delivery systems that combine carriers bone-targeting molecules potentially overcome the drawbacks presented by approaches. We have recently developed biodegradable, biocompatible nanoparticles (NP) made a conjugate between poly (D,Llactide- co-glycolic) acid alendronate, suitable for administration,...
Background & aims: Osteotropic drug-delivery systems have been proposed as a means to provide drugs with affinity bone tissues. Drugs or proteins linked chemically bone-seeking agents, such bisphosphonates (BPs); alternatively, drug-loaded nanoparticles used target specific tissues, tumor areas. In our current research, these approaches were merged by synthesizing novel polymer conjugate, from which targetable can be produced. Materials methods: An amino-BP, alendronate (ALE) was bound...
Gastrointestinal cancers, particularly colorectal cancer, are mainly influenced by the dietary factor. A diet rich in fruits and vegetables can help to reduce incidence of cancer thanks phenolic compounds, which possess antimutagenic anticarcinogenic properties. Polyphenols, alongside their well-known antioxidant properties, also show a pro-oxidative potential, makes it possible sensitize tumor cells oxidative stress. HO-1 combined with activity, when overexpressed cells, is involved...
In this paper the mechanisms involved in antibacterial effect of six 2E-alkenals [(E)-2-hexenal, (E)-2-eptenal, (E)-2-octenal, (E)-2-nonenal, (E)-2-decenal and (E,E)-2,4-decadienal] were investigated.We measured release carboxyfluorescein (CF) trapped liposomes phosphatidylcholine (PC) following exposure to aldehydes mentioned above, comparison with that elicited by hexanal nonanal; modifications thermotropic behaviour dimyristoylphosphatidylcholine (DMPC) induced (E,E)-2,4-decadienal (the...
Abstract— The fate of excitation energy and electron transfer to quinones within Chl‐ a ‐containing phosphatidyl choline liposomes has been investigated. bilayer membrane the liposome stabilizes Chl triplet state, as evidenced by three‐fold increase in lifetime over that observed ethanol solution. relative yield follows fluorescence yield, indicative quenching at singlet level. Triplet state lifetimes are markedly shortened concentration is increased, demonstrating occurs level well. This...
Steady-state and time-resolved spectra have been recorded for MgO: ${\mathrm{Cr}}^{3+}$ crystals as a function of temperature, excitation wavelength, concentration. The lifetimes emission from the various centers determined. Both prompt delayed broad-band fluorescence are emitted, but only is associated with cubic tetragonal sites. thermal quenching mechanism $R$-line lifetime reconsidered shown to involve repopulation $^{4}T_{2}$ state. For above $^{2}E$, 0.5 nsec...
(1) Background: Mangiferin (MGN) is a natural compound, showing anti-inflammatory and antioxidant activities for the potential treatment of eye diseases. The poor physicochemical features MGN (low solubility high instability) justify its nanoencapsulation into nanostructured lipid carriers (NLC) to improve ocular bioavailability. (2) Methods: Firstly, MGN-NLC were prepared by shear homogenization coupled with ultrasound (HSH-US) method. Finally, unloaded MGN-loaded NLC analyzed in terms...
The Cd(C5F6HO2)2·2H2O complex was investigated by X-ray crystallography, mass spectroscopy, 1H NMR TG−DTG thermal measurements, and infrared transmittance spectroscopy. single-crystal data show that the cadmium ion is chelated oxygens of hfa anion ligand bound to two cis-disposed water molecules. Deposition experiments, in a low-pressure horizontal hot-wall reactor, on optically transparent SiO2 substrates using above result CdO films. XRD measurements provide evidence these complexes...
Abstract— Upon laser photolysis of chlorophyll‐quinone solutions in ethanol, transients due to the chlorophyll triplet state ( C t ), cation radical (C + ) and semiquinone (Q ‐ can be observed. The rise Q parallels decay . demonstrating precursor role triplet. is second order, consistent with reverse electron transfer, has a rate constant which independent quinone potential, an activation energy 14kJ/mol mainly temperature dependence solvent viscosity. Triplet quenching yield are found...