G.A.P. Cirrone
A5058706916- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Laser-Plasma Interactions and Diagnostics
- Nuclear Physics and Applications
- Advanced Radiotherapy Techniques
- Radiation Effects in Electronics
- Laser-induced spectroscopy and plasma
- Particle Detector Development and Performance
- Boron Compounds in Chemistry
- Medical Imaging Techniques and Applications
- Ion-surface interactions and analysis
- High-pressure geophysics and materials
- Particle accelerators and beam dynamics
- DNA Repair Mechanisms
- Laser-Matter Interactions and Applications
- Radiation Effects and Dosimetry
- Atomic and Molecular Physics
- Magnetic confinement fusion research
- Particle Accelerators and Free-Electron Lasers
- Diamond and Carbon-based Materials Research
- Silicon and Solar Cell Technologies
- Effects of Radiation Exposure
- Ocular Oncology and Treatments
- Atomic and Subatomic Physics Research
- Thin-Film Transistor Technologies
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud
2016-2025
Istituto Nazionale di Fisica Nucleare
2016-2025
Centro Siciliano di Fisica Nucleare e di Struttura della Materia
2000-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Catania
2007-2024
University of Catania
2005-2023
Extreme Light Infrastructure Beamlines
2018-2023
University of Wollongong
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Perugia
2023
Czech Academy of Sciences, Institute of Physics
2012-2022
Institute for Physics
2013-2020
Geant4 is a software toolkit for the simulation of passage particles through matter. It used by large number experiments and projects in variety application domains, including high energy physics, astrophysics space science, medical physics radiation protection. Its functionality modeling capabilities continue to be extended, while its performance enhanced. An overview recent developments diverse areas presented. These include optimization complex setups; improvements propagation fields; new...
Geant4 is a software toolkit for the simulation of passage particles through matter. It used by large number experiments and projects in variety application domains, including high energy physics, astrophysics space science, medical physics radiation protection. Over past several years, major changes have been made to order accommodate needs these user communities, efficiently exploit growth computing power available advances technology. The adaptation multithreading, detector modeling...
Silicon carbide (SiC) is a compound semiconductor, which considered as possible alternative to silicon for particles and photons detection. Its characteristics make it very promising the next generation of nuclear particle physics experiments at high beam luminosity. Carbide detectors Intense Luminosity Investigations Applications (SiCILIA) project starting collaboration between Italian National Institute Nuclear Physics (INFN) IMM-CNR, aiming realization innovative detection systems based...
An overview of the electromagnetic (EM) physics Geant4 toolkit is presented.Two sets EM models are available: "Standard" initially focused on high energy (HEP) while "Low-energy" was developed for medical, space and other applications.The provide a faster computation but less accurate keV energies, more CPU time consuming.A common interface to has been allowing natural combination ultra-relativistic, relativistic low-energy same run providing both precision performance.Due this migration...
Abstract Protontherapy is hadrontherapy’s fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy’s superiority lies its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) 12 C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting efficient cell killing, i.e. higher Relative Biological...
The nuclear reaction known as proton-boron fusion has been triggered by a subnanosecond laser system focused onto thick boron nitride target at modest intensity (∼10^{16}W/cm^{2}), resulting in record yield of generated α particles. estimated value particles emitted per pulse is around 10^{11}, thus orders magnitude higher than any other experimental result previously reported. accelerated α-particle stream shows unique features terms kinetic energy (up to 10 MeV), duration (∼10 ns), and...
At the Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud (INFN-LNS) in Catania, Italy, first Italian protontherapy facility, named Centro AdroTerapia e Applicazioni Nucleari Avanzate (CATANA) has been built collaboration with University of Catania. It is based on use 62-MeV proton beam delivered by K=800 Superconducting Cyclotron installed and working at INFN-LNS since 1995. The facility mainly devoted to treatment ocular diseases like uveal melanoma. A line air assembled...
The spatial distribution of radiation-induced DNA breaks within the cell nucleus depends on radiation quality in terms energy deposition pattern. It is generally assumed that higher linear transfer (LET), greater damage complexity. Using a combined experimental and theoretical approach, we examined phosphorylation-dephosphorylation kinetics γ-H2AX foci, size 3D focus morphology, relationship between cellular end points (i.e., killing lethal mutations) after exposure to gamma rays, protons,...
Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An open source application was developed with aim to simulate two typical transport beam lines, one used for ocular therapy cell irradiations protons other ions. This tool allows evaluation primary total averaged LET predict their spatial distribution in voxelized or sliced geometries. In order reproduce a...
During particle therapy irradiation, positron emitters with half-lives ranging from 2 to 20 min are generated nuclear processes. The such that it is possible either detect the signal in treatment room using an in-beam emission tomography (PET) system, right after or quickly transfer patient a close PET/CT scanner. Since activity distribution spatially correlated dose, use PET imaging as indirect method assure quality of dose delivery. In this work, we present new dedicated system able...
The main direction proposed by the community of experts in field laser-driven ion acceleration is to improve particle beam features (maximum energy, charge, emittance, divergence, monochromaticity, shot-to-shot stability) order demonstrate reliable and compact approaches be used for multidisciplinary applications, thus, principle, reducing overall cost a laser-based facility compared conventional accelerator one and, at same time, demonstrating innovative more effective sample irradiation...
On the wake of results obtained so far at SPARC_LAB test-facility Laboratori Nazionali di Frascati (Italy), we are currently investigating possibility to design and build a new multi-disciplinary user-facility, equipped with soft X-ray Free Electron Laser (FEL) driven by ∼1 GeV high brightness linac based on plasma accelerator modules. This study is performed in synergy EuPRAXIA study. In this paper report about recent progresses going facility.
Abstract Despite aggressive therapeutic regimens, glioblastoma (GBM) represents a deadly brain tumor with significant aggressiveness, radioresistance and chemoresistance, leading to dismal prognosis. Hypoxic microenvironment, which characterizes GBM, is associated reduced effectiveness. Moreover, current irradiation approaches are limited by uncertain delineation severe side effects that comprehensively lead unsuccessful treatment worsening of the quality life GBM patients. Proton beam...
Hydrogenated amorphous silicon (a-Si:H) is a material having an intrinsically high radiation hardness that can be deposited on flexible substrates such as polyimide (PI). For these properties, a-Si:H used for the production of sensors. sensors successfully utilized in dosimetry, beam monitoring particle physics (X-ray, electron, gamma ray, and proton detection) radiotherapy, flux measurement space applications (study solar energetic particles stellar events), neutron measurements. In this...
The aim of this work was to test the suitability a PTW diamond detector for nonreference condition dosimetry in photon beams different energy (6 and 25 MV) field size (from 2.6 cm x 10 cm). Diamond behavior compared that Scanditronix p-type silicon diode RK ionization chamber. Measurements included output factors (OF). percentage depth doses (PDD) dose profiles. OFs measured with agreed within 1% those Only at MV, smallest size, chamber underestimated due averaging effects pointed shaped...
Statistical methods play a significant role throughout the life-cycle of physics experiments, being an essential component analysis. The present project in progress aims to develop object-oriented software Toolkit for statistical data contains variety Goodness-of-Fit (GoF) tests, from Chi-squared Kolmogorov-Smirnov, less known, but generally much more powerful tests such as Anderson-Darling, Goodman, Fisz-Cramer-von Mises, Kuiper. Thanks component-based design and usage standard abstract...
Hadrontherapy is a C++ , free and open source application developed using the Geant4 Monte Carlo libraries.The basic version of contained in official distribution (www.cern.ch/Geant4/download),inside category advanced examples.This permits simulation typical proton/ion transport beam line calculation dose fluence distributions inside test phantom.A more complete program separately maintained released by authors it offers wider set tools useful for Users interested proton/ion-therapy...
Nuclear fragmentation measurements are necessary when using heavy-ion beams in hadrontherapy to predict the effects of ion nuclear interactions within human body. Moreover, they also fundamental validate and improve Monte Carlo codes for their use planning tumor treatments. Nowadays, a very limited set carbon cross sections being measured, particular, our knowledge, no double-differential at intermediate energies available literature. In this work, we have measured angular distributions...
Generating pure proton beams using lasers for novel cancer therapies has long challenged researchers. In a new experiment, scientists irradiate thin hydrogen ribbon with high-power laser to generate large and population of protons.
Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton beams are used to precisely deliver the dose tumor target but generally considered ineffective against radioresistant tumors. Proton-Boron Capture Therapy (PBCT) novel approach aimed at enhancing biological effectiveness. PBCT exploits nuclear fusion reaction between low-energy protons and 11 B atoms, i.e. p+ B→ 3α (p-B), which supposed produce highly-DNA damaging α-particles exclusively across...