A5039093387- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Particle Detector Development and Performance
- Radiation Effects in Electronics
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Nuclear physics research studies
- Advanced Optical Sensing Technologies
- CCD and CMOS Imaging Sensors
- Optical Imaging and Spectroscopy Techniques
- Digital Radiography and Breast Imaging
- Photoacoustic and Ultrasonic Imaging
- Boron Compounds in Chemistry
- Radiation Dose and Imaging
- Radiopharmaceutical Chemistry and Applications
- Analog and Mixed-Signal Circuit Design
- Radioactivity and Radon Measurements
- Radioactive Decay and Measurement Techniques
- Advanced NMR Techniques and Applications
- Cardiac Imaging and Diagnostics
Istituto Nazionale di Fisica Nucleare, Sezione di Pisa
2014-2024
University of Pisa
2014-2024
Istituto Nazionale di Fisica Nucleare
1998-2021
Institut de l'Information Scientifique et Technique
2018
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro
1998-2001
Istituto Nazionale di Fisica Nucleare, Sezione di Padova
2001
Istituto Nazionale di Fisica Nucleare, Sezione di Firenze
1999
Particle therapy exploits the energy deposition pattern of hadron beams. The narrow Bragg Peak at end range is a major advantage but uncertainties can cause severe damage and require online verification to maximise effectiveness in clinics. In-beam Positron Emission Tomography (PET) non-invasive, promising in-vivo technique, which consists measurement β+ activity induced by beam-tissue interactions during treatment, presents highest correlation measured distribution with deposited dose,...
In this paper we present a new method for the determination of geometrical misalignments in cone-beam CT scanners, from analysis projection data generic object. No priori knowledge object shape and positioning is required. We show that cost function, which depends on misalignment parameters, can be defined using such function has local minimum correspondence to actual parameters system. Hence, calibration scanner carried out by minimizing standard optimization techniques. The developed...
During particle therapy irradiation, positron emitters with half-lives ranging from 2 to 20 min are generated nuclear processes. The such that it is possible either detect the signal in treatment room using an in-beam emission tomography (PET) system, right after or quickly transfer patient a close PET/CT scanner. Since activity distribution spatially correlated dose, use PET imaging as indirect method assure quality of dose delivery. In this work, we present new dedicated system able...
The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators the plan correctness. Among available imaging techniques, positron emission tomography (PET) has long been investigated then clinically applied to proton carbon beams. In 2013, Innovative Solutions for Dosimetry in Hadrontherapy (INSIDE) collaboration proposed an innovative bimodal concept combines in-beam PET scanner with tracking...
Abstract Objective . Monolithic scintillator crystals coupled to silicon photomultiplier (SiPM) arrays are promising detectors for PET applications, offering spatial resolution around 1 mm and depth-of-interaction information. However, their timing has always been inferior that of pixellated crystals, while the best results on have obtained with algorithms cannot operate in real-time a detector. In this study, we explore capabilities monolithic respect resolution, presenting new overcome...
Iterative image reconstruction algorithms for positron emission tomography (PET) require a sophisticated system matrix (model) of the scanner. Our aim is to set up such model offline YAP-(S)PET II small animal imaging tomograph in order use it subsequently with standard ML-EM (maximum-likelihood expectation maximization) and OSEM (ordered subset fully three-dimensional reconstruction. In general, can be obtained analytically, via measurements or Monte Carlo simulations. this paper, we...
A new type of silicon device has been realized that many properties comparable to, or better than, a conventional PMT (Photomultiplier Tube). This paper presents the first results using these photodetectors in place readout scintillators for possible PET (Positron Emission Tomography) applications. device, Silicon Photomultiplier (SiPM), is effectively an avalanche photodiode operated Geiger mode. In Geiger-mode detectors, very large current signal produced regardless size input, giving just...
Long axial field-of-view (LAFOV) systems have a much higher sensitivity than standard (SAFOV) PET for imaging the torso or full body, which allows faster and/or lower dose imaging. Despite its very high sensitivity, current total-body (TB-PET) throughput is limited by patient handling (positioning on bed) and often shortage of available personnel. This factor, combined with system costs, makes it hard to justify implementation these many academic nearly all routine nuclear medicine...
At the Department of Physics University Pisa, Italy, a new and fully engineered version YAP-(S)PET small animal scanner has been recently installed. The is able to perform both PET SPECT studies on animals. made up four heads: each one composed 4/spl times/4 cm/sup 2/ YAlO/sub 3/:Ce (or YAP:Ce) matrix 20/spl times/20 elements, 2/spl times/2/spl times/25 mm/sup 3/ each, coupled Position Sensitive Photomultiplier (PS-PMT) (Hamamatsu R2486). modules are positioned rotating gantry. switching...
Small-animal imaging has become an important technique for the development of new radiotracers, drugs and therapies. Many laboratories have now a combination different small-animal systems, which are being used by biologists, pharmacists, medical doctors physicists. The aim this paper is to give overview factors in design small animal, nuclear medicine experiment. Different experts summarize one specific aspect good
Simultaneous PET/MR/EEG (Positron Emission Tomography - Magnetic Resonance Electroencephalography), a new tool for the investigation of neuronal networks in human brain, is presented here within framework European Union Project TRIMAGE. The trimodal, cost-effective imaging makes use cutting edge technology both PET and MR fields. A novel type magnet (1.5T, non-cryogenic) has been built together with scanner that most advanced photodetectors (i.e., SiPM matrices), scintillators matrices...
In particle therapy, the uncertainty of delivered range during patient irradiation limits optimization treatment planning. Therefore, an in vivo verification device is required, not only to improve plan robustness, but also detect significant interfractional morphological changes itself. this article, effective and robust analysis regions with a discrepancy proposed. This study relies on by means in-beam Positron Emission Tomography (PET) was carried out INSIDE system installed at National...
Gamma rays from the N=Z−2 nucleus 50Fe have been observed, establishing rotational ground state band up to Jπ=11+ at 6.994 MeV excitation energy. The experimental Coulomb energy differences, obtained by comparison with isobaric analog states in its mirror 50Cr, confirm qualitative interpretation of backbending patterns terms successive alignments proton and neutron pairs. A quantitative agreement experiment has achieved exact shell model calculations, incorporating differences radii along...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The in-beam PET is a novel application to image the <formula formulatype="inline"> <tex Notation="TeX">$\beta^{+}$</tex></formula> activity induced in biological tissues by hadronic therapeutic beams. Thanks correlation existing between beam-delivered dose profiles and beam-induced profiles, vivo information about effective ion paths can be extracted from image. In-situ measurements, immediately...
This paper presents the performance assessment study of PET component IRIS PET/CT according to National Electrical Manufacturers Association NU 4-2008 standard. The is a high-resolution integrated system for and CT imaging small animals. We evaluated system, carrying out following measures: spatial resolution, sensitivity, counting rate capabilities, image quality parameters. Furthermore, two examples in vivo experiments are shown. average energy resolution whole module 14% at 511 keV....
The TRIMAGE project aims at developing a brain-dedicated PET/MR/EEG system able to perform simultaneous PET, MR and EEG acquisitions for application in schizophrenia. Both PET components have been designed this project. component consists of full ring with 18 sectors each comprising three square detector modules. modules are based on dual-layer staggered matrices LYSO crystals read out by silicon photomultipliers. This paper describes detail the final version detectors related electronics....
Morphological changes that may arise through a treatment course are probably one of the most significant sources range uncertainty in proton therapy. Non-invasive in-vivo monitoring is useful to increase quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs and carbon therapy treatments at National Center Oncological Hadrontherapy (CNAO). It currently clinical trial (ID: NCT03662373) has acquired PET data during various patients. In this work we analyze (IB-PET)...