M.G. Bisogni
A5005487784- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Particle Detector Development and Performance
- Nuclear Physics and Applications
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Digital Radiography and Breast Imaging
- CCD and CMOS Imaging Sensors
- Atomic and Subatomic Physics Research
- Radiation Effects in Electronics
- Advanced Semiconductor Detectors and Materials
- Dark Matter and Cosmic Phenomena
- AI in cancer detection
- Sensor Technology and Measurement Systems
- Analog and Mixed-Signal Circuit Design
- Semiconductor Quantum Structures and Devices
- Advanced Optical Sensing Technologies
- Advanced MRI Techniques and Applications
- Integrated Circuits and Semiconductor Failure Analysis
- Infrared Thermography in Medicine
- Global Cancer Incidence and Screening
- Advancements in PLL and VCO Technologies
- Electron and X-Ray Spectroscopy Techniques
- Boron Compounds in Chemistry
University of Pisa
2015-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Pisa
2015-2024
Istituto Nazionale di Fisica Nucleare
2006-2024
Consorzio Pisa Ricerche
2024
Institut de l'Information Scientifique et Technique
2018
Institute of Nuclear Physics
2016
Motion Control (United States)
2013
Fondazione Stella Maris
2011
Politecnico di Milano
2002-2003
Leonardo (United Kingdom)
2003
Particle therapy exploits the energy deposition pattern of hadron beams. The narrow Bragg Peak at end range is a major advantage but uncertainties can cause severe damage and require online verification to maximise effectiveness in clinics. In-beam Positron Emission Tomography (PET) non-invasive, promising in-vivo technique, which consists measurement β+ activity induced by beam-tissue interactions during treatment, presents highest correlation measured distribution with deposited dose,...
The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators the plan correctness. Among available imaging techniques, positron emission tomography (PET) has long been investigated then clinically applied to proton carbon beams. In 2013, Innovative Solutions for Dosimetry in Hadrontherapy (INSIDE) collaboration proposed an innovative bimodal concept combines in-beam PET scanner with tracking...
Ultra-High dose-per-pulse regimens (UHDP), necessary to trigger the "FLASH" effect, still pose serious challenges dosimetry. Dosimetry plays a crucial role, both significantly improve accuracy of radiobiological experiments fully understand mechanisms underlying effect and its dependencies on beam parameters, be able translate such into clinical practice. The standard ionization chamber in UHDP region is affected by effects electric field generated enormous density charges produced dose...
Abstract Objective . Monolithic scintillator crystals coupled to silicon photomultiplier (SiPM) arrays are promising detectors for PET applications, offering spatial resolution around 1 mm and depth-of-interaction information. However, their timing has always been inferior that of pixellated crystals, while the best results on have obtained with algorithms cannot operate in real-time a detector. In this study, we explore capabilities monolithic respect resolution, presenting new overcome...
This paper reports the development of dosimeters based on plastic scintillating fibers imaged by a charge-coupled device camera, and their performance evaluation through irradiations with electron Flash research accelerator located at Centro Pisano Radiotherapy. The dosimeter prototypes were composed piece fiber optically coupled to clear optical which transported scintillation signal readout systems (an imaging system photodiode). following properties tested: linearity, capability...
The characterization of a PET detector head based on continuous LYSO crystals and silicon photomultiplier (SiPM) arrays as photodetectors has been carried out for its use in the development small animal prototype. heads are composed crystal SiPM matrix with 64 pixels common substrate, fabricated specifically this project. Three 12 mm × 5 size different types painting have tested: white, black sides but white back crystal. best energy resolution, obtained crystal, is 16% FWHM. response linear...
Simultaneous PET/MR/EEG (Positron Emission Tomography - Magnetic Resonance Electroencephalography), a new tool for the investigation of neuronal networks in human brain, is presented here within framework European Union Project TRIMAGE. The trimodal, cost-effective imaging makes use cutting edge technology both PET and MR fields. A novel type magnet (1.5T, non-cryogenic) has been built together with scanner that most advanced photodetectors (i.e., SiPM matrices), scintillators matrices...
In vivo range monitoring techniques are necessary in order to fully take advantage of the high dose gradients deliverable hadrontherapy treatments. Positron emission tomography (PET) scanners can be used monitor beam-induced activation tissues and hence measure range. The INSIDE (Innovative Solutions for In-beam DosimEtry Hadrontherapy) in-beam PET scanner, installed at Italian National Center Oncological Hadrontherapy (CNAO, Pavia, Italy) synchrotron facility, has already been successfully...
In particle therapy, the uncertainty of delivered range during patient irradiation limits optimization treatment planning. Therefore, an in vivo verification device is required, not only to improve plan robustness, but also detect significant interfractional morphological changes itself. this article, effective and robust analysis regions with a discrepancy proposed. This study relies on by means in-beam Positron Emission Tomography (PET) was carried out INSIDE system installed at National...
Abstract FOOT (FragmentatiOn Of Target) is a nuclear physics experiment currently under construction that will measure differential cross sections for the production of secondary fragments induced by interactions proton and ion beams, up to 400 MeV/u, with human tissues. By extending energy range about 800 also provide data useful radio-protection in space, as understanding fragmentation processes take place spacecraft shieldings crucial their optimisation. The collaboration building...
The TRIMAGE project aims at developing a brain-dedicated PET/MR/EEG system able to perform simultaneous PET, MR and EEG acquisitions for application in schizophrenia. Both PET components have been designed this project. component consists of full ring with 18 sectors each comprising three square detector modules. modules are based on dual-layer staggered matrices LYSO crystals read out by silicon photomultipliers. This paper describes detail the final version detectors related electronics....
Morphological changes that may arise through a treatment course are probably one of the most significant sources range uncertainty in proton therapy. Non-invasive in-vivo monitoring is useful to increase quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs and carbon therapy treatments at National Center Oncological Hadrontherapy (CNAO). It currently clinical trial (ID: NCT03662373) has acquired PET data during various patients. In this work we analyze (IB-PET)...
Goal:In-beam Positron Emission Tomography (PET) is a technique for in-vivo non-invasive treatment monitoring proton therapy. To detect anatomical changes in patients with PET, various analysis methods exist, but their clinical interpretation problematic. The goal of this work to investigate whether the gamma-index analysis, widely used dose comparisons, an appropriate tool comparing in-beam PET distributions. Focusing on head-and-neck patient, we map and passing rate are sensitive...
The INSIDE project addresses the online dose monitoring in particle therapy issue.The proposed detectors exploit secondary neutral and charged particles emitted during treatment by irradiated volumes.The new detection techniques allow to return a measurement of released Bragg peak position.
We present the first results obtained with a prototype of PET read-out electronics trimodal PET/MRI/EEG TRIMAGE scanner. The is based on 64-channel TRIROC ASIC and an acquisition board that will control up to 12 ASICs. output each processed in parallel sent host system final version receive data from 18 boards. Blocks 64 SiPMs are one-to-one coupled dual-layer staggered LYSO crystal matrix read by single ASIC. FPGA reads sparse ASICs reconstructs for event full image light pattern coming...