A5001366515- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Radiation Detection and Scintillator Technologies
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Advanced X-ray and CT Imaging
- Glioma Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Neural dynamics and brain function
- Lanthanide and Transition Metal Complexes
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Advanced Radiotherapy Techniques
- Dark Matter and Cosmic Phenomena
- Advanced NMR Techniques and Applications
- Radioactive Decay and Measurement Techniques
- Nuclear Physics and Applications
- Digital Image Processing Techniques
- Environmental Policies and Emissions
- Advanced X-ray Imaging Techniques
- Genetics, Bioinformatics, and Biomedical Research
- Advancements in Photolithography Techniques
Life & Brain (Germany)
2021-2024
Forschungszentrum Jülich
2015-2024
University of Cologne
2021
Institut de l'Information Scientifique et Technique
2018
Université Paris-Sud
2001-2005
Université Paris Cité
2001-2005
Institut National de Physique Nucléaire et de Physique des Particules
2001-2005
Centre National de la Recherche Scientifique
2001-2005
RWTH Aachen University
1998-2002
CEA Paris-Saclay
2001
Summary After the successful clinical introduction of PET/CT, a novel hybrid imaging technology combining PET with versatile attributes MRI is emerging. At Forschungszentrum Jülich, one four prototypes available worldwide commercial 3T newly developed BrainPET insert has been installed, allowing simultaneous data acquisition and MRI. The equipped LSO crystals 2.5 mm width Avalanche photodiodes (APD) as readout electronics. Here we report on some performance characteristics obtained by...
For iterative, fully 3D positron emission tomography (PET) image reconstruction intrinsic symmetries can be used to significantly reduce the size of system matrix. The precalculation and beneficial memory-resident storage all nonzero matrix elements is possible where sufficient compression exists. Thus, times minimized independently projector more elaborate weighting schemes, e.g., volume-of-intersection (VOI), are applicable. A novel organization scanner-independent, adaptive projection...
Simultaneous PET/MR/EEG (Positron Emission Tomography - Magnetic Resonance Electroencephalography), a new tool for the investigation of neuronal networks in human brain, is presented here within framework European Union Project TRIMAGE. The trimodal, cost-effective imaging makes use cutting edge technology both PET and MR fields. A novel type magnet (1.5T, non-cryogenic) has been built together with scanner that most advanced photodetectors (i.e., SiPM matrices), scintillators matrices...
Simultaneous trimodal positron emission tomography/magnetic resonance imaging/electroencephalography (PET/MRI/EEG) resting state (rs) brain data were acquired from 10 healthy male volunteers. The rs-functional MRI (fMRI) metrics, such as regional homogeneity (ReHo), degree centrality (DC) and fractional amplitude of low-frequency fluctuations (fALFFs), well 2-[18F]fluoro-2-desoxy-d-glucose (FDG)-PET standardised uptake value (SUV), calculated the measures extracted default mode network (DMN)...
The symbiosis of neuronal activities and glucose energy metabolism is reflected in the generation functional magnetic resonance imaging (fMRI) electroencephalography (EEG) signals. However, their association with balance between excitation inhibition (E/I-B), which closely related to glutamate γ-aminobutyric acid (GABA) receptor availability (RA) GABAA mGluR5, remains unexplored. This research investigates these associations during resting state (RS) condition using simultaneously recorded...
Positron Emission Tomography (PET) images are prone to motion artefacts due the long acquisition time of PET measurements. Recently, simultaneous magnetic resonance imaging (MRI) and have become available in first generation Hybrid MR-PET scanners. In this work, elimination head neuroimages is achieved by a new approach utilising MR-based tracking combination with list mode data correction for acquisitions. The method comprises accurate measurements, an intra-frame minimising reconstruction...
Abstract Consistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However, role metabotropic receptors type 5 (mGluR5) this disease remains unclear. In study, we investigated their significance (using [ 11 C]ABP688) for psychopathology and cognition male patients with chronic schizophrenia healthy controls. patient group, lower mGluR5 binding potential (BP ND...
Abstract Objective. The pheno PET system is a plant dedicated positron emission tomography (PET) scanner consisting of fully digital photo multipliers with lutetium–yttrium oxyorthosilicate crystals and located inside custom climate chamber. Here, we present the setup PET, its data processing image reconstruction together performance. Approach. performance characterization follows national electrical manufacturers association (NEMA) standard for small animal systems number adoptions due to...
Use of iterative algorithms to reconstruct three-dimensional (3-D) positron emission tomography (PET) data requires the computation system probability matrix. The pure geometrical contribution can easily be approximated by length-of-intersection (LOI) between lines-of-response (LOR) and individual voxels. However, more accurate projectors are desirable. Therefore, we have developed a fast method for analytical calculation 3-D shape volume volumes-of-intersection (VOI). This provides an...
In hybrid magnetic resonance-positron emission tomography (MR-PET) studies with the Siemens 3T MR-BrainPET scanner an instantaneous reduction of PET sensitivity was observed during execution certain MR sequences. This interference investigated in detail custom-made as well standard clinical The radio-frequency pulses, switched gradient fields and constant field were examined relevant parameters resonance imaging (MRI) system air temperature within detectors. Our investigation comprised...
Amino acid PET using the tracer O-(2-[18F]fluoroethyl)-L-tyrosine (FET) has attracted considerable interest in neurooncology. Furthermore, initial studies suggested additional diagnostic value of FET radiomics brain tumor patient management. However, conclusiveness models strongly depends on feature generalizability. We here evaluated repeatability feature-based radiomics. A test–retest analysis based equivalent but statistically independent subsamples images was performed 50 newly diagnosed...
Simultaneous MR-PET-EEG (magnetic resonance imaging - positron emission tomography electroencephalography), a new tool for the investigation of neuronal networks in human brain, is presented here first time. It enables assessment molecular metabolic information with high spatial and temporal resolution given brain simultaneously. Here, we characterize brain's default mode network (DMN) healthy male subjects using multimodal fingerprinting by quantifying energy metabolism via 2-...
Accurate scatter correction is essential for qualitative and quantitative PET imaging. Until now, based on Monte Carlo simulation (MCS) has been recognized as the most accurate method of PET. However, major disadvantage MCS its long computational time, which makes it unfeasible clinical usage. Meanwhile, single (SSS) widely used correction. Nevertheless, SSS limited robustness dynamic measurements measurement large objects. In this work, a newly developed implementation using graphics...
Abstract Currently, the metabotropic glutamate receptor 5 (mGluR5) is subject of several lines research in context neurology and high interest as a target for positron-emission tomography (PET). Here, we assessed feasibility using [ 11 C]ABP688, specific antagonist radiotracer an allosteric site on mGluR5, to evaluate changes glutamatergic neurotransmission through mismatch-negativity (MMN) task part simultaneous synchronized multimodal PET/MR-EEG study. We analyzed effect MMN by comparing...
Abstract The glutamate and γ‐aminobutyric acid neuroreceptor subtypes mGluR 5 GABA A are hypothesized to be involved in the development of a variety psychiatric diseases. However, detailed information relating their vivo distribution is generally unavailable. Maps such distributions could potentially aid clinical studies by providing reference for normal neuroreceptors may also useful as covariates advanced functional magnetic resonance imaging (MR) studies. In this study, we propose...
Attenuation correction of PET data acquired in new hybrid MR-PET scanners which do not offer the possibility a measured attenuation can be done different ways. A previous report our group described method used templates. The present study utilizes knowledge-based segmentation approach applied on T1-weighted MR images. It examines position and tissue membership each voxel segments head volume into attenuation-differing regions: brain tissue, extracerebral soft skull, air-filled nasal...
Building on the success of positron emission tomography (PET)/CT scanners, a hybrid imaging technology, combining PET with versatile attributes magnetic resonance (MRI), has been in use for over ten years. At Forschungszentrum Jülich, one four prototypes available worldwide, commercial 3T MRI newly developed BrainPET insert, was installed 2008, allowing simultaneous data acquisition and MRI. Here, we report our ten-year-long experience methods technology through this paper numerous patients...
For high-resolution, iterative 3D PET image reconstruction the efficient implementation of forward-backward projectors is essential to minimise calculation time. Mathematically, are summarised as a system response matrix (SRM) whose elements define contribution voxels lines-of-response (LORs). In fact, SRM easily comprises billions non-zero evaluate tremendous number LORs provided by state-of-the-art scanners. Hence, performance algorithms, e.g. maximum-likelihood-expectation-maximisation...
In the framework of German Plant Phenotyping Network (DPPN) we developed a novel PET scanner for imaging plants and crops. The observation carbon transport within plant becomes possible by using 11CO2 as tracer. use rather short living isotope C-11 asks with high dynamic range. That means fast timing data rates are important features which let us choose Philips Digital Photon Counter (DPC) photo detector. Due to detectors special crystal matrix arrangement system will allow measurements...
Objective Quantitative values derived from PET brain images are of high interest for neuroscientific applications. Insufficient DT correction (DTC) can lead to a systematic bias the output parameters obtained by detailed analysis time activity curves (TACs). The DTC method currently used Siemens 3T MR BrainPET insert is global, i.e., differences in losses between detector blocks not considered, leading inaccurate and, consequently, measurements masked bias. However, following careful...
One challenge for PET-MR hybrid imaging is the correction attenuation of 511 keV annihilation radiation by required RF transmit and/or receive coils. Although there are strategies building PET transparent Tx/Rx coils, such optimised coils still cause significant leading to artefacts and biases in reconstructed activity concentrations. We present a straightforward method measure simultaneous MR-PET based on natural 176Lu background contained scintillator detector without requirement an...
With the novel PET Reconstruction Software Toolkit (PRESTO) a versatile C++ Library for fully 3D iterative image reconstructions becomes available.
In this paper, a Maximum Posteriori Reconstruction algorithm is applied for the first time to Siemens 3TMR BrainPET scanner. The implementation of done in PET REconstruction Software TOolkit. This software able cope with 3D listmode data and can deal specificities Simulated was used assess performance algorithm. Several priori distributions were tested results are compared OSEM reconstruction. Simultaneously acquired MR human patient show feasibility promising expected improve clinical applications.
Due to technological developments in positron emission tomography (PET) detectors and PET-MR integration, the simultaneous measurement of PET-MR-EEG has become feasible, offering possibility exploring complementary information provided by each modality. Studies have already shown benefits using PET-MR, however, such achievements come with different technical practical challenges. In this context, we aim give an overview challenges involved integrating electroencephalography hybrid scanners...