A5060326878- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Fluorine in Organic Chemistry
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Adenosine and Purinergic Signaling
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Click Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Lung Cancer Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Medical Imaging and Pathology Studies
- Boron Compounds in Chemistry
- Nuclear Physics and Applications
- Angiogenesis and VEGF in Cancer
- Neurological disorders and treatments
University Hospital Cologne
2016-2025
University of Cologne
2016-2025
Forschungszentrum Jülich
2016-2025
Max Planck Institute for Metabolism Research
2014-2024
University of Lübeck
2010-2023
University Hospital Ulm
1999-2023
Johannes Gutenberg University Mainz
2023
University Hospital Schleswig-Holstein
2023
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2019-2022
University of Bonn
2011-2022
Gallium-68 (Ga-68)-labeled tracers for imaging expression of the prostate-specific membrane antigen (PSMA) such as [68Ga]Ga-PSMA-HBED-CC have already demonstrated high potential detection recurrent prostate cancer. However, compared to Ga-68, a labeling with fluorine-18 (F-18) would offer advantages respect availability, production amount, and image resolution. [18F]DCFPyL is promising F-18-labeled candidate PSMA-positron emission tomography (PET) that has been recently introduced. In...
Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future interventional trials against in would strongly benefit from biomarkers that support diagnosis.To investigate potential novel radiotracer 18F-PI-2620 as biomarker patients with clinically diagnosed PSP.In this cross-sectional study, participants underwent dynamic positron emission tomography (PET) 0 to 60 minutes after...
PURPOSE: Previous studies have shown that bone metastases are revealed by magnetic resonance imaging (MRI) or marrow scintigraphy several months before they visible conventional (BS). We present a new approach for detecting in patients with breast cancer. compared findings obtained fluoride ion (F-18) and positron emission tomography (PET) those BS. PATIENTS AND METHODS: Thirty-four cancer were prospectively examined using F-18–PET BS performed within 3 weeks of each other. Metastatic...
The molecular mechanisms that control the balance between antiangiogenic and proangiogenic factors initiate angiogenic switch in tumors remain poorly defined. By combining chemical genetics with multimodal imaging, we have identified an autocrine feed-forward loop tumor cells which tumor-derived VEGF stimulates production via VEGFR2-dependent activation of mTOR, substantially amplifying initial signal. Disruption this by perturbation or knockdown VEGFR2 dramatically inhibited vitro vivo....
Abstract We have determined the ability of positron emission tomography (PET) with thymidine analogue 3′-deoxy-3′-[18F]fluorothymidine (FLT) to detect manifestation sites malignant lymphoma, assess proliferative activity, and differentiate aggressive from indolent tumors. In this prospective study, FLT-PET was done additionally routine staging procedures in 34 patients lymphoma. Sixty minutes after i.v. injection ∼330 MBq FLT, transmission scanning done. Tracer uptake lymphoma evaluated...
Positron emission tomography (PET) with both 2'-deoxy-2'-[(18)F]fluoro-D-glucose (FDG) and 3'-[(18)F]fluoro-3'-deoxy-L-thymidine (FLT) was evaluated respect to the accuracy of early prediction nonprogression following erlotinib therapy, independent from epidermal growth factor receptor (EGFR) mutational status, in patients previously untreated advanced non-small-cell lung cancer (NSCLC).Thirty-four stage IV NSCLC were this phase II trial. Changes FDG FLT uptake after 1 (early) 6 (late) weeks...
Several studies outlined the sensitivity of <sup>68</sup>Ga-labeled PET tracers against prostate-specific membrane antigen (PSMA) for localization relapsed prostate cancer in patients with renewed increase (PSA), commonly referred to as biochemical recurrence. Labeling PSMA <sup>18</sup>F offers numerous advantages, including improved image resolution, longer half-life, and increased production yields. The aim this study was assess PSA-stratified performance <sup>18</sup>F-labeled tracer...
See Whitwell (doi:10.1093/brain/awy001) for a scientific commentary on this article. A stereotypical anatomical propagation of tau pathology has been described in Alzheimer's disease. According to recent concepts (network degeneration hypothesis), is thought be indicative misfolded proteins possibly spreading along functional networks. If true, accumulation should correlate functionally connected brain regions. Therefore, we examined whether independent components could identified the...
Abstract Two novel methods for copper‐mediated aromatic nucleophilic radiofluorination were recently reported. Evaluation of these reveals that, although both are efficient in small‐scale experiments, they inoperative the production positron emission tomography (PET) tracers. Since high base content turned out to be responsible low radiochemical conversions, a “low base” protocol has been developed which affords 18 F‐labeled arenes from diaryliodonium salts and aryl pinacol boronates...
Abstract The potential of many 18 F‐labeled (hetero)aromatics for applications in positron emission tomography remains underexplored because convenient procedures their radiosynthesis are lacking. Consequently, simple methods to prepare radiofluorinated (hetero)arenes highly sought after. Herein, we report the beneficial effect primary and secondary alcohols on Cu‐mediated F‐labeling. This observation contradicts assumption that such inappropriate solvents aromatic fluorination. Therefore,...
The aim of this study was to investigate the potential combined textural feature analysis contrast-enhanced MRI (CE-MRI) and static O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET for differentiation between local recurrent brain metastasis radiation injury since CE-MRI often remains inconclusive. Fifty-two patients with new or progressive contrast-enhancing lesions on after radiotherapy (predominantly stereotactic radiosurgery) metastases were additionally investigated using FET PET. Based...
The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition amyloid-β. We assessed relationship between symptoms, vivo tau pathology, amyloid distribution, and hypometabolism variants using novel multimodal PET imaging techniques. Tau pathology was primarily observed brain regions related to symptoms overlapped with areas hypometabolism. In contrast, amyloid-β diffusely distributed over entire cortex. may thus serve as a valuable biomarker for...
Mutations in the isocitrate dehydrogenase (IDH mut) gene have gained paramount importance for prognosis of glioma patients. To date, reliable techniques a preoperative evaluation IDH genotype remain scarce. Therefore, we investigated potential O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET radiomics using textural features combined with static and dynamic parameters FET uptake noninvasive prediction genotype. Prior to surgery, 84 patients newly diagnosed untreated gliomas underwent standard...
A novel radiofluorination procedure using only precursor and [<sup>18</sup>F]fluoride without the need for azeotropic drying, base other ingredients was developed.
Abstract In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [ 18 F] AV ‐1451) and beta‐amyloid burden 11 C]PiB) on degree neurodegeneration (i.e., glucose metabolism measured FDG ‐ ) in patients Alzheimer's disease. Across brain regions, observed an interactive effect tau deposition which was most pronounced parietal lobe. Elevated associated stronger influence accumulation metabolism. Our data provide first vivo...