A5065313812- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Protease and Inhibitor Mechanisms
- Fluorine in Organic Chemistry
- Cardiac Structural Anomalies and Repair
- Cancer, Hypoxia, and Metabolism
- Cyclopropane Reaction Mechanisms
- PARP inhibition in cancer therapy
- Head and Neck Cancer Studies
- Advanced X-ray and CT Imaging
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Research Studies
- Ear and Head Tumors
- Neuroendocrine Tumor Research Advances
- DNA Repair Mechanisms
- Chemical Reactions and Isotopes
- Neuropeptides and Animal Physiology
- Medical Imaging and Pathology Studies
- Signaling Pathways in Disease
- Cancer, Stress, Anesthesia, and Immune Response
- Integrated Circuits and Semiconductor Failure Analysis
- S100 Proteins and Annexins
- Ubiquitin and proteasome pathways
- Radiation Dose and Imaging
Essen University Hospital
2020-2024
University of Duisburg-Essen
2020-2024
Deutschen Konsortium für Translationale Krebsforschung
2021-2024
Klinik und Poliklinik für Nuklearmedizin
2021-2023
German Marine Research Consortium
2020
Forschungszentrum Jülich
2016-2017
University of Cologne
2017
Max Planck Institute for Metabolism Research
2014-2015
University Hospital Cologne
2014-2015
Cologne Business School
2014
Abstract Two novel methods for copper‐mediated aromatic nucleophilic radiofluorination were recently reported. Evaluation of these reveals that, although both are efficient in small‐scale experiments, they inoperative the production positron emission tomography (PET) tracers. Since high base content turned out to be responsible low radiochemical conversions, a “low base” protocol has been developed which affords 18 F‐labeled arenes from diaryliodonium salts and aryl pinacol boronates...
A novel radiofluorination procedure using only precursor and [<sup>18</sup>F]fluoride without the need for azeotropic drying, base other ingredients was developed.
Fibroblast activation protein inhibitor (FAPI) PET/CT is a new tool in the diagnostic workup of cancer. With growing volume applications, pitfalls and common findings need to be considered for 68Ga-FAPI image interpretation. The aim this study was summarize report PET/CT. Methods: Ninety-one patients underwent whole-body with either FAPI-04 (n = 25) or FAPI-46 66). Findings were rated consensus session 2 experienced readers. Pitfalls defined as focal localized uptake above background level...
<b>Introduction:</b> Bone and soft tissue sarcomas express fibroblast activation protein (FAP) on tumor cells associated fibroblast. Therefore, FAP is a promising therapeutic diagnostic target. Novel radio-labelled FAP-Inhibitors (e.g. <sup>68</sup>Ga-FAPI46) have shown high uptake in positron emission tomography (PET) sarcoma patients. Here we report endpoints of the FAPI-PET prospective observational trial. <b>Methods:</b> Forty-seven patients with bone or undergoing clinical...
The aim of this retrospective analysis was to examine the pattern cardiac 68Ga-fibroblast-activation protein-α inhibitor (FAPI) uptake in patients after acute myocardial infarction (AMI) using PET and investigate its association with results coronary angiography. We correlated FAPI biomarkers damage including left ventricular function.A cohort 10 no history artery disease underwent 18 ± 20.6 days AMI (ST-segment elevation [n = 5] non-ST-segment 5]), respectively. SUVmax, SUVmean, SUVpeak...
Tumoral fibroblast activation protein expression is associated with proliferation and angiogenesis can be visualized by PET/CT. We examined the prognostic value of [
Positron emission tomography (PET) using small ligands of the fibroblast activation protein (FAP) was recently introduced. However, optimal uptake time has not been defined yet. Here, we systematically compare early (~ 10 min p.i.) and late 60 FAPI-46 imaging in patients with various types cancer.This is a retrospective single-institutional study. Imaging performed at Essen University Hospital, Germany. A total 69 who underwent dual time-point for either restaging (n = 52, 75%) or staging...
Fibroblast activation protein α (FAPα) is expressed at high levels in several types of tumors. Here, we report the expression pattern FAPα solitary fibrous tumor (SFT) and its potential use as a radiotheranostic target. <b>Methods:</b> We analyzed messenger RNA biopsy samples from SFT patients using immunohistochemistry multiplexed immunofluorescence. Tracer uptake detection efficacy were assessed undergoing clinical <sup>68</sup>Ga-FAPα inhibitor (FAPI)–46 PET,<sup>18</sup>F-FDG PET,...
Combined cardiac 68Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of myocardial damage after an acute infarction (AMI). Purpose this pilot study was to evaluate simultaneous Ga-68-FAPI-46-PET/MR delayed phase AMI. Eleven underwent hybrid 68Ga-FAPI-46 PET/MRI post Standardized uptake values fibroblast activation volume (FAV) were calculated...
In a recent contribution of Scott et al., the substrate scope Cu-mediated nucleophilic radiofluorination with [18F]KF for preparation 18F-labeled arenes was extended to aryl- and vinylstannanes. Based on these findings, potential this reaction production clinically relevant positron emission tomography (PET) tracers investigated. To end, radiofluorodestannylation using trimethyl(phenyl)tin as model re-evaluated respect different parameters. The resulting labeling protocol applied...
18 F‐Labeled aromatic amino acids exhibit great potential for diagnostic applications using positron emission tomography. However, the introduction of F into compounds remains challenging, and novel fluorination methods facilitating easy access to F‐labeled arenes are highly sought after. In recent years, metal‐mediated have been reported transferred radiochemistry. Based on Cu‐mediated radiofluorination, a two‐step synthesis no‐carrier‐added (n.c.a.) 6‐[ F]fluoro‐ l ‐tryptophan was...
The aim of this study was to investigate conditions for reliable quantification sub-centimeter lesions with low18F,68Ga, and124I uptake using a silicon photomultiplier-based PET/CT system.A small tumor phantom investigated under challenging but clinically realistic resembling prostate and thyroid cancer lymph node metastases (6 spheres 3.7-9.7 mm in diameter, 9 different activity concentrations ranging from about 0.25-25 kBq/mL, signal-to-background ratio 20). Radionuclides positron...
New-generation silicon-photomultiplier (SiPM)-based PET/CT systems exhibit an improved lesion detectability and image quality due to a higher detector sensitivity. Consequently, the acquisition time can be reduced while maintaining diagnostic quality. The aim of this study was determine lowest 18F-FDG PET without loss information optimise reconstruction parameters (image algorithm, number iterations, voxel size, Gaussian filter) by phantom imaging. Moreover, patient data are evaluated...
Abstract The radioiodine isotope pair 124 I/ 131 I is used in a theranostic approach for patient-specific treatment of differentiated thyroid cancer. Lesion detectability notably higher PET (positron emission tomography) than gamma camera imaging but can be limited small and low uptake lesions. recently introduced silicon-photomultiplier-based (SiPM-based) PET/CT (computed systems outperform previous-generation detector sensitivity, coincidence time resolution, spatial resolution. Hence,...
The NETTER-1, VISION, and TheraP trials proved the efficacy of repeat intravenous application small radioligands. Application by subcutaneous, intraperitoneal, or oral routes is an important alternative may yield comparable favorable organ tumor radioligand uptake. Here, we assessed biodistribution for various in healthy mice models cancer expressing somatostatin receptor (SSTR), prostate-specific membrane antigen (PSMA), fibroblast activation protein (FAP). <b>Methods:</b> Healthy...
The cardiac bioavailability of peptide drugs that inhibit harmful intracellular protein-protein interactions in cardiovascular diseases remains a challenging task drug development. This study investigates whether non-specific cell-targeted is available timely manner at its intended biological destination, the heart, using combined stepwise nuclear molecular imaging approach. An octapeptide (heart8P) was covalently coupled with trans-activator transcription (TAT) protein transduction domain...
[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and need to limit starting activity. The automation previously reported protocol synthesis challenging, it requires transferring microvolumes reagents, which platforms cannot accommodate. We report revised, high yield, automated [18F]PARPi, with final doses over 20 GBq.
Ziel/Aim Positron-Emission-Tomography (PET) using small-ligands of the fibroblast activation protein (FAP) was recently introduced. However, optimal uptake time not defined yet. Here, we systematically compare early (~ 10 min p.i.) and late 60 FAPI-46 imaging in patients with various cancers.
Ziel/Aim SFTs are rare mesenchymal tumors frequently diagnosed late due to delayed occurrence of symptoms. Localized mostly treated by resection, while there is no effective standard treatment for advanced, metastatic stages. Hence, accurate imaging essential, especially detection limits current modalities. Therefore, we aim assess accuracy and impact on management Ga-68-FAPI-46 PET.