A5054878846- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Radiation Effects and Dosimetry
- Radiation Effects in Electronics
- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Laser Design and Applications
- Gyrotron and Vacuum Electronics Research
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Advanced X-ray Imaging Techniques
- Particle Detector Development and Performance
- Advanced X-ray and CT Imaging
- Superconducting Materials and Applications
- Microwave Engineering and Waveguides
- Engineering Applied Research
- Ion-surface interactions and analysis
- Graphite, nuclear technology, radiation studies
- Breast Cancer Treatment Studies
- Cardiac tumors and thrombi
- Nuclear and radioactivity studies
- Sarcoma Diagnosis and Treatment
- Cleft Lip and Palate Research
Charles University
2018-2022
University Hospital in Motol
2018-2020
Istituto Oncologico Romagnolo
2017
Sorain Cecchini Tecno (Italy)
2013
Techint (Italy)
2003
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati
2003
National Agency for New Technologies, Energy and Sustainable Economic Development
2002
Various in vivo experimental works carried out on different animals and organs have shown that it is possible to reduce the damage caused healthy tissue still preserving therapeutic efficacy tumor tissue, by drastically reducing total time of dose delivery (<200 ms). This effect, called FLASH immediately attracted considerable attention within radiotherapy community, due possibility widening window treating effectively tumors which appear radioresistant conventional techniques....
Conventional air ionization chambers (ICs) exhibit ion recombination correction factors that deviate substantially from unity when irradiated with dose per pulse magnitudes higher than those used in conventional radiotherapy. This fact makes these devices unsuitable for the dosimetric characterization of beams ultra-high as FLASH radiotherapy.We present design, development, and an ultra-thin parallel plate IC can be rate (UHDR) deliveries minimal recombination.The charge collection...
FLASH radiotherapy (RT) is an emerging technique in which beams with ultra-high dose rates (UH-DR) and per pulse (UH-DPP) are used. Commercially available active real-time dosimeters have been shown to be unsuitable such conditions, due severe response nonlinearities. In the present study, a novel diamond-based Schottky diode detector was specifically designed realized match stringent requirements of FLASH-RT.
Ultra-High dose-per-pulse regimens (UHDP), necessary to trigger the "FLASH" effect, still pose serious challenges dosimetry. Dosimetry plays a crucial role, both significantly improve accuracy of radiobiological experiments fully understand mechanisms underlying effect and its dependencies on beam parameters, be able translate such into clinical practice. The standard ionization chamber in UHDP region is affected by effects electric field generated enormous density charges produced dose...
A diamond detector prototype was recently proposed by Marinelli et al. (Medical Physics 2022, https://doi.org/10.1002/mp.15473) for applications in ultrahigh-dose-per-pulse (UH-DPP) and ultrahigh-dose-rate (UH-DR) beams, as used FLASH radiotherapy (FLASH-RT). In the present study, such so-called flashDiamond (fD) investigated from dosimetric point of view, under pulsed electron beam irradiation. It then commissioning an ElectronFlash linac (SIT S.p.A., Italy) both conventional UH-DPP...
Purpose: The electron linac ElectronFlash installed at Institut Curie (Orsay, France) is entirely dedicated to FLASH irradiation for radiobiological and pre-clinical studies. system was designed deliver an ultra-high-dose rate per pulse (UHDR) (above 106 Gy/s) a very high average dose different energies durations. A campaign of tests measurements performed obtain full reliable characterizations the beam delivered dose, which are necessary experiments. Methods: Faraday cup used measure...
Ultra-high dose rate (UHDR) beams for FLASH radiotherapy present significant dosimetric challenges. Although novel approaches decreasing or correcting ion recombination in ionization chambers are being proposed, applicability of ionimetric dosimetry to UHDR is still under investigation. Solid-state sensors have been recently investigated as a valuable alternative real-time measurements, especially relative and beam monitoring. Among them, Silicon Carbide (SiC) represents very promising...
Since Favaudon's paper of 2014, there has been an increasing interest in FLASH radiotherapy. The modality could represent a breakthrough radiation oncology; nevertheless, it brings new scientific and technological challenges. Currently, one the main limits community to cope with is lack common platform experiment with. Considering this framework, possibility readapting existing linac platforms produce beam particularly attractive different attempts have already made. purpose article...
The FLASH effect is a radiobiological phenomenon that has garnered considerable interest in the clinical field. Pre-clinical experimental studies have highlighted its potential to reduce side effects on healthy tissues while maintaining isoeffectiveness tumor tissues, thus widening therapeutic window and enhancing effectiveness of radiotherapy. achieved through administration complete radiation dose within brief time frame, shorter than 200 milliseconds, and, therefore, utilizing remarkably...
Objective.A reliable determination of the instantaneous dose rate (I-DR) delivered in FLASH radiotherapy treatments is believed to be crucial assess so-called effect preclinical and biological studies. At present, no detectors nor real-time procedures are available do that ultra high (UH-DR) electron beams, typically consisting ofμs pulses characterized by I-DRs order MGy/s. A dosimetric system proposed possibly overcoming above reported limitation, based on recently developed flashDiamond...
The use of ultra-high dose rate beams (UHDR) (> 40 Gy/s) for radiotherapy, despite its advantage exhibiting the FLASH effect that improves sparing healthy tissues, faces challenges in dosimetry and beam monitoring since standard dosimeters like ionization chamber experience saturation effects at such high rates. Silicon carbide (SiC) detectors have recently been demonstrated to be dose-rate independent with low-energy pulsed electron up an instantaneous 5.5 MGy/s, has emerged as a...
The Novac7 and Liac are linear accelerators (linacs) dedicated to intraoperative radiation therapy (IORT), which produce high energy, very dose-per-pulse electron beams. characteristics of the heads different compared conventional accelerators. aim this work was investigate specific beams using Monte Carlo method. code BEAMnrc has been employed model head simulate simulation preliminarily validated by comparing simulated dose distributions with those measured means EBT radiochromic film....
The aim of this study was to investigate the dosimetric characteristics electron beams generated by light intraoperative accelerator, Liac® (SORDINA, Italy), using Monte Carlo (MC) calculations. Moreover we investigated possibility characterizing dosimetry with a minimal set data. In fact accelerator commissioning requires measurements both percentage depth doses (PDDs) and off-axis profiles for all possible combinations energy, applicator diameter bevelled angle. geometry water phantom were...
Radiation therapy is currently the most utilized technique for treatment of tumors by means ionizing radiation, such as electrons, protons and x/gamma rays, depending on type, size depth cancer mass. has in general fulfilled main requirement targeting thus damaging malignant cells sparing healthy tissues best possible. In this scenario, electron linear accelerators have been operated viable tools delivery both high-energetic electrons x-ray beams, which are obtained via bremsstrahlung...
Abstract Flash Therapy is a revolution in cancer cure since it spares healthy tissue from the damage of ionization radiations without decreasing its effectiveness tumor control. To allow implementation FLASH therapy concept into actual clinical use and treat deep tumors, Very High Electron Energy (VHEE) should be achieved range 50-150 MeV. In framework VHEE project carried out at Sapienza University, collaboration with INFN, we investigate main issues designing compact C band (5.712 GHz)...
Accurate dosimetry of ultra-high dose-rate beams using diamond detectors remains challenging, primarily due to the elevated photocurrent peaks exceeding input dynamics precision electrometers. This work aimed at demonstrating effectiveness compact gated-integration electronics in conditioning current (>20 mA) generated by a highly sensitive (S ≃ 26 nC/Gy) custom-made photoconductor under electron FLASH irradiation, as well real-time monitoring beam dose and dose-rate. For emerging...
Abstract FLASH radiotherapy, which employs ultra-high dose rate (UHDR) beams with a mean > 40 Gy/s and total irradiation time < 200 ms to treat tumors, exhibits remarkable ability spare healthy tissue while maintaining the same efficiency in treating tumors. However, UHDR presents challenges dosimetry beam monitoring, as dosimeters recommended for conventional i.e. ionization chambers, show saturation at such high rates delivered per pulse hence cannot be employed accurate future...
Partial breast irradiation for the treatment of early-stage cancer patients can be performed by means Intra Operative electron Radiation Therapy (IOeRT). One main limitations this technique is absence a planning system (TPS) that could greatly help in ensuring proper coverage target volume during irradiation. An IOeRT TPS has been developed using fast Monte Carlo (MC) and an ultrasound imaging to provide best strategy (electron beam energy, applicator position bevel angle) facilitate...
The aim of this study is to investigate radioprotection issues that must be addressed when dedicated accelerators for intraoperative radiotherapy (IORT) are used in operating rooms. Recently, a new version mobile IORT accelerator (LIAC Sordina SpA, Italy) with 12 MeV electron beam has been implemented. This energy necessary some specific pathology treatments allow better coverage thick lesions. At an 10 MeV, leakage and scattered x-ray radiation (stray radiation) coming from the device...
LIAC® and NOVAC are two mobile linear accelerators dedicated to intraoperative radiation therapy (IORT), generating electron beams in the energy range of 3-12 MeV. Due high dose-per-pulse (up 70 mGy per pulse), 2003 Italian National Institute Health (ISS) stated that "for measure dose water reference conditions, ionization chambers cannot be employed no published dosimetry protocol can used". As a consequence, ferrous sulphate (or, alternatively alanine) was recommended. Based on...