A5030205219- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Biocrusts and Microbial Ecology
- Tardigrade Biology and Ecology
- Radiation Detection and Scintillator Technologies
- Boron Compounds in Chemistry
- Effects of Radiation Exposure
- Chemical Reactions and Isotopes
- Nuclear Physics and Applications
- Radiation Effects and Dosimetry
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Particle accelerators and beam dynamics
- Spaceflight effects on biology
- Neonatal Respiratory Health Research
- Medical Imaging Techniques and Applications
- Polar Research and Ecology
- ATP Synthase and ATPases Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Engineering Applied Research
- Advanced Materials Characterization Techniques
- Nuclear physics research studies
- Cancer-related Molecular Pathways
- Frailty in Older Adults
Université Paris-Saclay
2017-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2003-2024
Université Grenoble Alpes
2024
Université Paris Sciences et Lettres
2018-2024
Inserm
2019-2024
Institut Curie
2013-2024
Centre National de la Recherche Scientifique
2019-2024
University of Palermo
2024
CEA Grenoble
2024
University of Modena and Reggio Emilia
2024
Abstract Purpose: One of the main limitations to anticancer radiotherapy lies in irreversible damage healthy tissues located within radiation field. “FLASH” irradiation at very high dose-rate is a new treatment modality that has been reported specifically spare normal tissue from late radiation-induced toxicity animal models and therefore could be promising strategy reduce toxicity. Experimental Design: Lung responses FLASH were investigated by qPCR, single-cell RNA sequencing (sc-RNA-Seq),...
UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates is a recently started European Joint Research Project the aim to develop and improve dosimetry standards FLASH radiotherapy, very high energy electron (VHEE) laser-driven medical accelerators. This paper gives short overview about current state of developments electrons protons, as well particles related challenges in due rate during radiation pulses. We summarize objectives plans project...
FLASH radiotherapy (RT) is an emerging technique in which beams with ultra-high dose rates (UH-DR) and per pulse (UH-DPP) are used. Commercially available active real-time dosimeters have been shown to be unsuitable such conditions, due severe response nonlinearities. In the present study, a novel diamond-based Schottky diode detector was specifically designed realized match stringent requirements of FLASH-RT.
Abstract Radiation Induced Lung Injury (RILI) is one of the main limiting factors thorax irradiation, which can induce acute pneumonitis as well pulmonary fibrosis, latter being a life-threatening condition. The order cellular and molecular events in progression towards fibrosis key to physiopathogenesis disease, yet their coordination space time remains largely unexplored. Here, we present an interactive murine single cell atlas lung response generated from C57BL6/J female mice. This tool...
Purpose: The electron linac ElectronFlash installed at Institut Curie (Orsay, France) is entirely dedicated to FLASH irradiation for radiobiological and pre-clinical studies. system was designed deliver an ultra-high-dose rate per pulse (UHDR) (above 106 Gy/s) a very high average dose different energies durations. A campaign of tests measurements performed obtain full reliable characterizations the beam delivered dose, which are necessary experiments. Methods: Faraday cup used measure...
Tardigrades are microscopic animals renowned for their ability to withstand extreme conditions, including high doses of ionizing radiation (IR). To better understand radio-resistance, we first characterized induction and repair DNA double- single-strand breaks after exposure IR in the model species Hypsibius exemplaris . Importantly, found that rate induced was roughly equivalent human cells, suggesting plays a predominant role tardigrades’ radio-resistance. identify novel...
Abstract Minibeam radiation therapy (MBRT) is an innovative synchrotron radiotherapy technique able to shift the normal tissue complication probability curves significantly higher doses. However, its exploration was hindered due limited and expensive beamtime at synchrotrons. The aim of this work develop a cost-effective equipment perform systematic radiobiological studies in view MBRT. Tumor control for various tumor entities will be addressable as well unravel distinct biological...
Tardigrades are microscopic animals renowned for their ability to withstand extreme conditions, including high doses of ionizing radiation (IR). To better understand radio-resistance, we first characterized induction and repair DNA double- single-strand breaks after exposure IR in the model species Hypsibius exemplaris . Importantly, found that rate induced was roughly equivalent human cells, suggesting plays a predominant role tardigrades’ radio-resistance. identify novel...
The development of high performance computing facilities makes possible a massive production nuclear data in full microscopic framework. Taking advantage the individual potential calculations more than 7000 nuclei, new statistical scission-point model, called SPY, has been developed. It gives access to absolute available energy at scission point, which allows use parameter-free microcanonical description calculate distributions and mean values all fission observables. SPY uses richness...
Small diamond detectors are useful for the dosimetry of high-energy proton beams. However, linear energy transfer (LET) dependence has been observed in literature with such solid state detectors. A novel synthetic detector recently become commercially available from manufacturer PTW-Freiburg (PTW microDiamond type 60019). This study was designed to thoroughly characterize four clinical beams, order investigate their response and reproducibility high LET regions. Very good dosimetric...
Abstract AsiDNA™, a cholesterol-coupled oligonucleotide mimicking double-stranded DNA breaks, was developed to sensitize tumour cells radio- and chemotherapy. This drug acts as decoy hijacking the damage response. Previous studies have demonstrated that standalone AsiDNA™ administration is well tolerated with no additional adverse effects when combined chemo- and/or radiotherapy. The lack of normal tissue complication encouraged further examination into role in cells. research demonstrates...
Abstract Translation of electron FLASH radiotherapy in clinical practice requires the use high energy accelerators to treat deep tumours and Very High Electron Energy (VHEE) could represent a valid technique achieve this goal. In scenario, VHEE linac is under study at University La Sapienza Rome (Italy) collaboration with Italian Institute for Nuclear Research (INFN) Institut Curie (France). Here we present preliminary results compact C-band system aiming reach an accelerating gradient pulse...
To rapidly assess healthy tissue toxicities induced by new anti-cancer therapies (i.e., radiation alone or in combination with drugs), there is a critical need for relevant and easy-to-use models. Consistent the ethical desire to reduce use of animals medical research, we propose monitor lung toxicity using an ex vivo model. Briefly, freshly prepared organotypic slices from mice were irradiated, without being previously exposed chemotherapy, treatment was evaluated analysis cell division...
Tardigrades, microscopic animals found in virtually all ecosystems, are renowned for their remarkable ability to withstand extreme conditions. Recent studies have identified novel tardigrade specific protein families that aid resistance desiccation and ionizing radiation (IR). Notably, a DNA binding called Dsup (for damage suppressor) has been protect from X-ray human cells hydroxyl radicals vitro . However, only two species within the Hypsibioidea superfamily.To better understand mechanisms...
Ultra-high dose rate (UHDR/FLASH) irradiations, along with particle minibeam therapy (PMBT) are both emerging as promising alternatives to current radiotherapy techniques thanks their improved healthy tissue sparing and similar tumor control. Monte Carlo (MC) modeling of a commercial machine delivering 5-7 MeV electrons at UHDR. This model was used afterward compare measurements against simulations for an experimental setup combining FLASH PMBT modalities. We modeled the main accelerator...
ABSTRACT Tardigrades, microscopic animals found in virtually all ecosystems, are renowned for their remarkable ability to withstand extreme conditions. Recent studies have identified novel tardigrade specific protein families that aid resistance desiccation and ionizing radiation (IR). Notably, a DNA binding called Dsup (for damage suppressor) has been protect from X-ray human cells hydroxyl radicals vitro . However, only two species within the Hypsibioidea superfamily. To better understand...