A5088125473- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Virus-based gene therapy research
- Radiation Detection and Scintillator Technologies
- Radiation Effects in Electronics
- Nanoplatforms for cancer theranostics
- Radiation Effects and Dosimetry
- Ultrasound and Hyperthermia Applications
- Anesthesia and Neurotoxicity Research
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Veterinary Oncology Research
- Radiation Dose and Imaging
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Advanced NMR Techniques and Applications
- Boron Compounds in Chemistry
- Radiomics and Machine Learning in Medical Imaging
- Body Contouring and Surgery
CRUK/MRC Oxford Institute for Radiation Oncology
2020-2024
University of Oxford
2020-2024
Skåne University Hospital
2019-2024
Lund University
2010-2024
Medical Research Council
2020-2024
University of Lausanne
2016-2023
Institute of Radiation Physics
2016-2023
University Hospital of Lausanne
2017
Karolinska Institutet
2007
Abstract Purpose: Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this could also occur higher mammals. Experimental Design: Pig skin was used to investigate potential difference toxicity irradiation delivered at an ultrahigh dose rate called “FLASH-RT” conventional “Conv-RT.” A clinical, phase I, single-dose escalation trial (25–41 Gy) performed 6...
Here, we highlight the potential translational benefits of delivering FLASH radiotherapy using ultra-high dose rates (>100 Gy⋅s-1). Compared with conventional dose-rate (CONV; 0.07-0.1 Gy⋅s-1) modalities, showed that did not cause radiation-induced deficits in learning and memory mice. Moreover, 6 months after exposure, CONV caused permanent alterations neurocognitive end points, whereas induce behaviors characteristic anxiety depression impair extinction memory. Mechanistic investigations...
Abstract Purpose: Recent data have shown that single-fraction irradiation delivered to the whole brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit neurocognitive deficits mice. This observation has important clinical implications for management invasive and treatment-resistant tumors involves relatively large volumes with high cytotoxic doses. Experimental Design: Therefore, we aimed at simultaneously investigating antitumor efficacy neuroprotective...
Objective: Recent in vivo results have shown prominent tissue sparing effect of radiotherapy with ultra-high dose rates (FLASH) compared to conventional (CONV). Oxygen depletion has been proposed as the underlying mechanism, but vitro data support this lacking. The aim current study was compare FLASH CONV irradiation under different oxygen concentrations vitro. Methods: Prostate cancer cells were irradiated at (relative partial pressure ranging between 1.6 and 20%) a 10 MeV electron beam...
The purpose of this work was to establish an empirical model the ion recombination in Advanced Markus ionization chamber for measurements high dose rate/dose-per-pulse electron beams. In addition, we compared observed calculations using standard Boag two-voltage-analysis method, more general theoretical models, and semiempirical equation presented by Burns McEwen.Two independent methods were used investigate recombination: (a) Varying grid tension linear accelerator (linac) gun (controls...
The Oriatron eRT6 is an experimental high dose-per-pulse linear accelerator (linac) which was designed to deliver electron beam with variable dose-rates, ranging from a few Gy/min up hundreds of Gy/s. It built study the radiobiological effects dose-per-pulse/dose-rate irradiation, in context preclinical and cognitive studies. In this work, we report on commissioning monitoring prototype linac.The characterized different steps. output stability studied by performing repeated measurements over...
The aim of this study was to assess the suitability Gafchromic EBT3 films for reference dose measurements in beam a prototype high dose-per-pulse linear accelerator (linac), capable delivering electron beams with mean dose-rate (Ḋm ) ranging from 0.07 3000 Gy/s and pulse (Ḋp up 8 × 106 Gy/s. To do this, we evaluated overall uncertainties film dosimetry as well energy dependence their response.Our dosimetric system composed combination flatbed scanner calibrated against an ionization chamber...
PurposeUltra-high-dose-rate FLASH radiation therapy has been shown to minimize side effects of irradiation in various organs while keeping antitumor efficacy. This property, called the effect, caused enthusiasm oncology community because it opens opportunities for safe dose escalation and improved outcome. Here, we investigated impact ultra-high-dose-rate versus conventional-dose-rate (CONV) total body (TBI) on humanized models T-cell acute lymphoblastic leukemia (T-ALL) normal human...
FLASH radiotherapy has emerged as a treatment technique with great potential to increase the differential effect between normal tissue toxicity and tumor response compared conventional radiotherapy. To evaluate feasibility of in relevant clinical setting, we have commenced safety study canine cancer patients spontaneous superficial solid tumors or microscopic residual disease, using electron beam our modified linear accelerator. The setup for was established short applicator nominal...
FLASH irradiation reportedly produces less normal tissue toxicity, while maintaining tumour response. To investigate oxygen's role in the 'FLASH effect', we assessed DNA damage levels following at different oxygen tensions, doses and dose rates.
Irradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several vivo studies. Few cell lines have investigated vitro, and previous results are inconsistent. Assuming that oxygen depletion accounts for the FLASH sparing effect, no should appear cells irradiated low doses normoxia.Seven cancer (MDA-MB-231, MCF7, WiDr, LU-HNSCC4, HeLa [early passage subclone]) lung fibroblasts (MRC-5) were ranging from 0 12 Gy using (≥800 Gy/s) or...
Background FLASH radiotherapy (RT) is a novel method for delivering ionizing radiation, which has been shown in preclinical studies to have normal tissue sparing effect and maintain anticancer efficacy as compared conventional RT. Treatment of head neck tumors with RT commonly associated severe toxicity, hence the potentially makes it especially advantageous treating oral tumors. In this work, objective was study adverse effects dogs spontaneous treated Methods Privately-owned macroscopic...
Introduction We have previously adapted a clinical linear accelerator (Elekta Precise, Elekta AB) for ultra-high dose rate (UHDR) electron delivery. To enhance reliability in future FLASH radiotherapy trials, the aim of this study was to introduce and evaluate an upgraded beam control system tuning process safe precise UHDR Materials Methods The is designed interrupt based on 1) preset number monitor units (MUs) measured by detector, 2) pulses pulse-counting diode, or 3) delivery time. For...
In the novel and promising radiotherapy technique known as FLASH, ultra-high dose-rate electron beams are used. As a step towards clinical trials, dosimetric advances will be required for accurate dose delivery of FLASH. The purpose this study was to determine whether built-in transmission chamber linear accelerator can used real-time dosimeter monitor ultra-high-dose-rate beams. This done by modeling drop-in ion-collection efficiency with increasing dose-per-pulse values, so that ion...