A5040261291- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Bat Biology and Ecology Studies
- Neuroscience of respiration and sleep
- Cholesterol and Lipid Metabolism
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Immunotherapy and Immune Responses
- Radiation Therapy and Dosimetry
- Psoriasis: Treatment and Pathogenesis
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Nutrition, Genetics, and Disease
- Immune responses and vaccinations
- Liver Disease Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- RNA Research and Splicing
- Infant Nutrition and Health
- Cannabis and Cannabinoid Research
- Lipid metabolism and biosynthesis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Sphingolipid Metabolism and Signaling
- Advanced MRI Techniques and Applications
Université Claude Bernard Lyon 1
2017-2024
Institut National des Sciences Appliquées de Lyon
2014-2024
Laboratoire de Mécanique des Contacts et des Structures
2020-2024
Université de Lyon
2024
Laboratoire CarMeN
2014-2024
Centre National de la Recherche Scientifique
2022-2024
Molécules d'Intérêt Biologique
2024
Inserm
2013-2020
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020
Instituto Multidisciplinario de Biología Celular
2020
Low-grade inflammation observed in obesity is a risk factor for cardiovascular disease. Recent studies revealed that this would be linked to gut-derived endotoxemia during fat digestion high-fat diets, but nothing known about the effect of lipid composition. The study was designed test impact oil composition diets on endotoxin metabolism and mice. C57/Bl6 mice were fed 8 wk with chow or isocaloric isolipidic enriched oils differing fatty acid composition: milk fat, palm oil, rapeseed...
The intake of ω-3 polyunsaturated fatty acids (PUFAs), which are abundant in marine fish meat and oil, has been shown to exert many beneficial effects. mechanisms behind those effects numerous, including interference with the arachidonic acid cascade that produces pro-inflammatory eicosanoids, formation novel bioactive lipid mediators, change pattern secreted adipocytokines. In our study, we show eicosapentaenoic (EPA) increases adiponectin from 3T3-L1 adipocytes plasma mice as early 4 days...
Dairy products derived from the milk of cows fed in pastures are characterised by higher amounts conjugated linoleic acid and α-linolenic (ALA), several studies have shown their ability to reduce cardiovascular risk. However, specific metabolic effects compared with standard dairy a high-fat diet (HFD) context remain largely unknown; this is what we determined present study focus on intestinal parameters. The experimental animals were for 12 weeks HFD containing 20 % fat form pasture cream...
Interleukin 17A (IL-17A) is a proinflammatory cytokine involved in the pathogenesis of chronic inflammatory diseases. In field immunometabolism, we have studied impact IL-17A on lipid metabolism human vitro-generated monocyte-derived dendritic cells (DCs). Microarrays and lipidomic analysis revealed an intense remodeling induced by DCs. increased 2-12 times amounts phospholipids, cholesterol, triglycerides, cholesteryl esters Palmitic (16:0), stearic (18:0), oleic (18:ln-9c) acid were main...
The association of the APOE4 (vs. APOE3) isoform with an increased risk Alzheimer’s disease (AD) is unequivocal, but underlying mechanisms remain incompletely elucidated. A prevailing hypothesis incriminates impaired ability to clear neurotoxic amyloid-β peptides (Aβ) from brain as main mechanism linking apolipoprotein etiology. APOE protein mediates lipid transport both within and periphery, suggesting that lipids may be potential co-factors in APOE4-associated physiopathology. present...
The association of the APOE4 (vs APOE3) isoform with an increased risk Alzheimer’s Disease (AD) is unequivocal, but underlying mechanisms remain incompletely elu-cidated. A prevailing hypothesis incriminates impaired ability to clear neurotoxic amyloid-β peptides (Aβ) from brain as main mechanism linking apolipoprotein disease aetiology. APOE protein mediates lipid transport both within and periphery, suggesting that lipids may be potential co-factors in...
ABSTRACT Cancer research aims to identify new therapeutic targets and provide patients with more effective therapies that generate fewer deleterious side effects. Previous studies have demonstrated the role of small nucleolar RNAs (snoRNAs) in many physiological pathological cellular processes, including cancers. SnoRNAs are a group non-coding involved different post-transcriptional modifications ribosomal RNAs. Recently, we identified snoRNA, named jouvence (snoRNA-jou) humans. Here,...
In small hibernators, global downregulation of the endocannabinoid system (ECS), which is involved in modulating neuronal signaling, feeding behavior, energy metabolism, and circannual rhythms, has been reported to possibly drive physiological adaptation hibernating state. brown bears (Ursus arctos), we hypothesized that beyond an overall suppression ECS, seasonal shift endocannabinoids compounds could be linked bear's peculiar features include hibernation without arousal episodes capacity...
Abstract In small hibernators, global downregulation of the endocannabinoid system (ECS), which is involved in modulating neuronal signaling, feeding behavior, energy metabolism, and circannual rhythms, has been reported to possibly drive physiological adaptation hibernating state. We hypothesized that specific changes should occur brown bears ( Ursus arctos ) due features, including hibernation during half year at only mild hypothermia while remaining physically inactive without drinking or...
Abstract In small hibernators, global downregulation of the endocannabinoid system (ECS), which is involved in modulating neuronal signaling, feeding behavior, energy metabolism, and circannual rhythms, has been reported to possibly drive physiological adaptation hibernating state. brown bears ( Ursus arctos ), we hypothesized that beyond an overall suppression ECS, seasonal shift endocannabinoids compounds could be linked bear’s peculiar features include hibernation without arousal episodes...
Abstract In small hibernators, global downregulation of the endocannabinoid system (ECS), which is involved in modulating neuronal signaling, feeding behavior, energy metabolism, and circannual rhythms, has been reported to possibly drive physiological adaptation hibernating state. brown bears ( Ursus arctos ), we hypothesized that beyond an overall suppression ECS, seasonal shift endocannabinoids compounds could be linked bear’s peculiar features include hibernation without arousal episodes...