A5029734468- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Antioxidant Activity and Oxidative Stress
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
- Neuroscience of respiration and sleep
- Free Radicals and Antioxidants
- Bat Biology and Ecology Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Inflammatory mediators and NSAID effects
- Photosynthetic Processes and Mechanisms
- Alcohol Consumption and Health Effects
- Redox biology and oxidative stress
- Sphingolipid Metabolism and Signaling
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Acid Research Studies
Université Claude Bernard Lyon 1
2014-2024
Institut National des Sciences Appliquées de Lyon
2010-2024
Centre National de la Recherche Scientifique
2022-2024
Université de Lyon
2024
Laboratoire de Mécanique des Contacts et des Structures
2020-2024
Laboratoire CarMeN
2013-2020
Inserm
2010-2020
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020
Hospices Civils de Lyon
2009-2020
Instituto Multidisciplinario de Biología Celular
2020
Low-grade inflammation observed in obesity is a risk factor for cardiovascular disease. Recent studies revealed that this would be linked to gut-derived endotoxemia during fat digestion high-fat diets, but nothing known about the effect of lipid composition. The study was designed test impact oil composition diets on endotoxin metabolism and mice. C57/Bl6 mice were fed 8 wk with chow or isocaloric isolipidic enriched oils differing fatty acid composition: milk fat, palm oil, rapeseed...
Imeglimin is the first in a new class of oral glucose-lowering agents currently phase 2b development. Although imeglimin improves insulin sensitivity humans, molecular mechanisms are unknown. This study used model 16-week high-fat, high-sucrose diet (HFHSD) mice to characterize its antidiabetic effects. Six-week treatment significantly decreased glycemia, restored normal glucose tolerance, and improved without modifying organs, body weights, food intake. was associated with an increase...
Neuroinflammatory processes are considered a double-edged sword, having both protective and detrimental effects in the brain. Microglia, brain's resident innate immune cells, key component of neuroinflammatory response. There is growing interest developing drugs to target microglia control processes. In this regard, docosahexaenoic acid (DHA), n-3 polyunsaturated fatty acid, promising molecule regulate pro-inflammatory cytokine production. Several works reported that bioavailability DHA...
Stroke is a devastating neurological disorder that characterized by the sudden disruption of blood flow to brain. Lipids are essential components brain structure and function play pivotal roles in stroke pathophysiology. Dysregulation lipid signaling pathways modulates key cellular processes such as apoptosis, inflammation, oxidative stress, exacerbating ischemic injury. In present review, we summarize lipids pathology different models (cell cultures, animal, human studies). Additionally,...
Lipid oxidation is implicated in a wide range of pathophysiogical disorders, and leads to reactive compounds such as fatty aldehydes, which the most well known 4-hydroxy-2E-nonenal (4-HNE) issued from 15-hydroperoxyeicosatetraenoic acid (15-HpETE), an arachidonic (AA) product. In addition 15-HpETE, 12(S)-HpETE synthesized by 12-lipoxygenation platelet AA. We first show that 12-HpETE can be degraded vitro into 4-hydroxydodeca-(2E,6Z)-dienal (4-HDDE), specific aldehyde homologous 4-HNE....
Oxidative stress can impair proteasome function, both of which are features neurodegenerative diseases. Inhibition function leads to protein accumulation and cell death. We discovered recently the formation highly reactive g-ketoaldehydes, isoketals (IsoKs), neuroketals (NeuroKs) as products isoprostane neuroprostane pathways free radical-induced lipid peroxidation that analogous cyclooxygenase-derived levuglandins (LGs). Because aldehydes much less than IsoKs have been shown inhibit we...
Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular degeneration and brain disorders Alzheimer’s Parkinson’s diseases. Lipid storage organelles (lipid droplets, LDs), accumulate many cell types response to stress, it now clear LDs function not only stores but also dynamic regulators the stress response. However, whether these are always protective or can be deleterious unknown. Here, we...
Neuroprostanes are prostaglandin-like compounds produced by free radical-induced peroxidation of docosahexaenoic acid, which is highly enriched in the brain. We previously described formation reactive gamma-ketoaldehydes (isoketals) as products isoprostane pathway arachidonic acid. therefore explored whether isoketal-like (neuroketals) also formed via neuroprostane pathway. Utilizing mass spectrometric analyses, neuroketals were found to be abundance vitro during oxidation acid and greater...
Hydroxy-alkenals, such as 4-hydroxy-2(E)-nonenal (4-HNE; from n-6 fatty acids), are degradation products of acid hydroperoxides, including those generated by free radical attack membrane polyunsaturated acyl moieties. The cytotoxic effects hydroxy-alkenals well known and mainly attributable to their interaction with different molecules form covalent adducts. Indeed, ethanolamine phospholipids (PEs) can be covalently modified in a cellular system hydroxy-alkenals, 4-HNE,...
The intake of ω-3 polyunsaturated fatty acids (PUFAs), which are abundant in marine fish meat and oil, has been shown to exert many beneficial effects. mechanisms behind those effects numerous, including interference with the arachidonic acid cascade that produces pro-inflammatory eicosanoids, formation novel bioactive lipid mediators, change pattern secreted adipocytokines. In our study, we show eicosapentaenoic (EPA) increases adiponectin from 3T3-L1 adipocytes plasma mice as early 4 days...
Both inflammation and oxidative injury are features of Alzheimer's disease (AD), but the contribution these intertwined phenomena to loss working memory in this is unclear. We tested hypothesis that highly reactive γ-ketoaldehyd
Consumption of DHA has numerous beneficial effects, but little is known about these effects during the first few days dietary intake. The main objectives present study were to determine time course incorporation into phospholipids in different mouse tissues and supplementation on adiponectin leptin secretion. Mice fed either a control diet or DHA-rich diet, some killed 0, 4, 8, 16 32. Some mice for d, then maintained sixteen more (washout period). increased plasma secretion by 2·4-fold as...
The quality of the lubricant between cartilaginous joint surfaces impacts joint’s mechanistic properties. In this study, we define biochemical, ultrastructural, and tribological signatures synovial fluids (SF) from patients with degenerative (osteoarthritis-OA) or inflammatory (rheumatoid arthritis-RA) pathologies in comparison SF healthy subjects. Phospholipid (PL) concentration increased pathological contexts, but proportion PL relative to overall lipids decreased. Subtle changes chain...
AceDoPC® is a structured glycerophospholipid that targets the brain with docosahexaenoic acid (DHA) and neuroprotective in experimental ischemic stroke. stabilized form of physiological 2-DHA-LysoPC an acetyl group at sn1 position; preventing migration DHA from sn2 to position. In this study we aimed know bioavailability 13C-labeled after oral intake single dose 13C-AceDoPC®, comparison 13C-DHA triglycerides (TAG), using gas chromatography/combustion/isotope ratio mass spectrometry...
Obesity is a complex disease highly related to diet and lifestyle associated with low amount of thermogenic adipocytes. Therapeutics that regulate brown adipocyte recruitment activity represent interesting strategies fight overweight comorbidities. Recent studies suggest role for several fatty acids their metabolites, called lipokines, in the control thermogenesis. The purpose this work was analyze lipokines brown/brite formation. We used validated human model, multipotent adipose-derived...