A5003438547- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Thermoregulation and physiological responses
- Erythrocyte Function and Pathophysiology
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- Exercise and Physiological Responses
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
Institut de Biologie Valrose
2023-2025
Inserm
2020-2024
Université Côte d'Azur
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Obesity is a complex disease highly related to diet and lifestyle associated with low amount of thermogenic adipocytes. Therapeutics that regulate brown adipocyte recruitment activity represent interesting strategies fight overweight comorbidities. Recent studies suggest role for several fatty acids their metabolites, called lipokines, in the control thermogenesis. The purpose this work was analyze lipokines brown/brite formation. We used validated human model, multipotent adipose-derived...
Thermogenic brown and brite adipocytes convert chemical energy from nutrients into heat. Therapeutics that regulate adipocyte recruitment activity represent interesting strategies to control fat mass such as in obesity or cachexia. The peroxisome proliferator-activated receptor (PPAR) family plays key roles the maintenance of adipose tissue regulation thermogenic activity. Activation these receptors induce browning white adipocyte. purpose this work was characterize role carnosic acid (CA),...
MicroRNAs play a pivotal role in the regulation of adipose tissue function and have emerged as promising therapeutic candidates for management obesity associated comorbidities. Among them, miR-1 could be potential biomarker metabolic diseases contribute to homeostasis. However, thorough research is required fully elucidate impact on human adipocyte thermogenesis metabolism. This study aimed explore effect browning, process whose activation has been linked protection counteraction. Human...
Animal models remain important for the study of human pathologies. The most widely used model (mouse) is an endothermic mammal like humans, maintained at ambient temperatures (22 °C). Its energy metabolism overactivated, a situation rarely observed in humans thanks to various adaptations (clothing, heating…). thermoneutral zone defined as range that allows organism regulate body temperature without using additional thermoregulatory processes. There are many examples divergent results between...