A5004028259- Orthopaedic implants and arthroplasty
- Lubricants and Their Additives
- Force Microscopy Techniques and Applications
- Tribology and Wear Analysis
- Lipid Membrane Structure and Behavior
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Polymer Surface Interaction Studies
- Titanium Alloys Microstructure and Properties
- Tribology and Lubrication Engineering
- Orthopedic Infections and Treatments
- Knee injuries and reconstruction techniques
- Air Quality and Health Impacts
- Advanced X-ray and CT Imaging
- Engineering Technology and Methodologies
- Orthopedic Surgery and Rehabilitation
- Endodontics and Root Canal Treatments
- Extracellular vesicles in disease
- Advanced materials and composites
- Metal Alloys Wear and Properties
- RNA Interference and Gene Delivery
- Nanopore and Nanochannel Transport Studies
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
Laboratoire de Mécanique des Contacts et des Structures
2015-2024
Université de Lyon
2008-2024
Institut National des Sciences Appliquées de Lyon
2011-2023
Université Claude Bernard Lyon 1
2012-2023
Centre National de la Recherche Scientifique
2012-2023
Interface (United States)
2006-2018
Lyon College
2014
Institut Lumière Matière
2013
Tribo-electrochemical behavior in physiological solution of two β-type (100-x)(Ti-45Nb)-xGa (x = 4, 8 wt%) alloys, alongside β-Ti-45Nb and medical grade Ti-6Al-4V ELI, was investigated. Microstructure mechanical were evaluated by X-ray diffraction, microhardness ultrasonic method. Tribocorrosion tests (open circuit potential, anodic potentiostatic tests) performed using a reciprocating pin-on-disk tribometer under constant load. Degradation mechanisms are similar for the alloys: plastic...
The role of phospholipid bilayers in controlling and reducing frictional forces between biological surfaces is investigated by three complementary experiments: friction are measured using a homemade tribometer, mechanical resistance to indentation AFM, lipid bilayer degradation controlled situ during testing fluorescence microscopy. DPPC the solid phase generate coefficients as low 0.002 (comparable that found for cartilage) stable through time. DOPC formed vesicle fusion method or...
Lipid-based carriers such as liposomes represent one of the most advanced classes drug delivery systems. Their clinical success relies on their composition, similar to that cell membrane. cellular specificity often a ligand–receptor interaction. Although differences in physicochemical properties membrane between tumor and nontumor cells have been reported, they are not systematically used for purposes. In this report, new approach was developed ensure selective targeting based physical...
Air pollution causes around 4.2 million premature deaths worldwide every year [1]. Several studies have demonstrated the harmful effects of poor air quality on health: onset respiratory diseases [2], cardiovascular problems [3] and neurological disorders [4]. For traffic-related pollution, exhaust emissions are widely studied their level is actually in decrease, thanks to relevant policies. Still, this not case for non-exhaust (brakes, tires, pavement, vehicle components re-suspension...
The quality of the lubricant between cartilaginous joint surfaces impacts joint’s mechanistic properties. In this study, we define biochemical, ultrastructural, and tribological signatures synovial fluids (SF) from patients with degenerative (osteoarthritis-OA) or inflammatory (rheumatoid arthritis-RA) pathologies in comparison SF healthy subjects. Phospholipid (PL) concentration increased pathological contexts, but proportion PL relative to overall lipids decreased. Subtle changes chain...
In the context of shoulder surgical replacement, a new generation spherical interposition implants has been developed, with implant being mobile spacer rubbing against glenoid cartilage and humeral bone cavity. The aim present study was to compare pyrocarbon (PyC) versus cobalt-chromium (CoCr) implants, regarding preservation regeneration surrounding tissues. effect biomaterials on chondrocytes analysed in vitro. Murine primary were grown discs made PyC or CoCr using two culture media mimic...
Abstract A better knowledge of synovial fluid (SF) ultrastructure is required to further understand normal joint lubrication and metabolism. The aim the present study was elucidate SF structural features in healthy joints from three mammalian species different size compared with biomimetic SF. High-resolution analysis performed using transmission electron microscopy (TEM) scanning (SEM) environmental SEM/wet mode complemented by TEM SEM cryogenic methods. Laser-scanning confocal (LCM) used...
Introduction: Pre-clinical testing of hemiarthroplasty devices requires that the tribological conditions present in vivo with live cartilage be closely duplicated. A current limitation involves use cell-culture media as lubricant. Study Aim: to develop and test a new hyaluronan-phospholipid based medium (HA–phospholipid medium) combines rheological frictional properties synovial fluid nourishing culture keep cells alive. Materials Methods: The HA–phospholipid consisted added phospholipid...
While periodontal ligament cells are sensitive to their 3D biomechanical environment, only a few in vitro models have been used investigate the mechanobiological behavior. The objective of current study was assess capability fibrous scaffold transmit mechanical loading cells. Three-dimensional polycaprolactone (PCL) scaffolds were synthetized through electrospinning. Scaffolds seeded with human (103 mL−1) subjected static (n = 9) or sinusoidal axial compressive an in-house bioreactor 9). At...
The fluidity of lipid membranes is an essential property for their biological function. Here we use a dynamic surface forces apparatus to probe flow at the nanoscale on supported phospholipid bilayers and present direct mechanical measurements fluidity. We show that gel-phase DPPC deposited glass behave as rigid flow, whereas fluid DOPC are mobile slide with very low friction coefficient. These findings provide new perspectives investigation lubricant properties design biomaterial biomedical...
The friction between two rubbing surfaces lubricated by water can be diminished if they are coated with phospholipidic bilayers or brushes of polyelectrolytes. In the case a coating lipid membranes, is lower when lipids in gel phase rather than liquid phase. We investigated response fluid to mechanical load under shear using non-equilibrium molecular dynamics simulations (NEMD) understand whether this difference could come from intermonolayer sliding. system composed single fully hydrated...