A5053285577- Extracellular vesicles in disease
- Tribology and Wear Analysis
- Bone Metabolism and Diseases
- Lubricants and Their Additives
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Osteoarthritis Treatment and Mechanisms
- Molecular Sensors and Ion Detection
- Photoreceptor and optogenetics research
- Traumatic Brain Injury and Neurovascular Disturbances
- Knee injuries and reconstruction techniques
Université Claude Bernard Lyon 1
2022
Centre National de la Recherche Scientifique
2022
University of Carthage
2022
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
2022
Institut National des Sciences Appliquées de Lyon
2022
The quality of the lubricant between cartilaginous joint surfaces impacts joint’s mechanistic properties. In this study, we define biochemical, ultrastructural, and tribological signatures synovial fluids (SF) from patients with degenerative (osteoarthritis-OA) or inflammatory (rheumatoid arthritis-RA) pathologies in comparison SF healthy subjects. Phospholipid (PL) concentration increased pathological contexts, but proportion PL relative to overall lipids decreased. Subtle changes chain...
Abstract Matrix vesicles (MVs) are 100–300 nm spherical structures released by mineralization competent cells to initiate formation of apatite, the mineral component in bones. Among proteins present MVs, annexin A6 (AnxA6) is thought be ubiquitously distributed MVs’ lumen, on surface internal and external leaflets membrane also inserted lipid bilayer. To determine molecular mechanism(s) that lead different locations AnxA6, we hypothesized occurrence a pH drop during mineralization. Such...
The morphology of fibroblast-like synoviocytes (FLS) issued from the synovial fluid (SF) patients suffering osteoarthritis (OA), rheumatoid arthritis (RA), or healthy subjects (H), as well ultrastructure and mechanical properties FLS-secreted extracellular vesicles (EV), were analyzed by confocal microscopy, transmission electron atomic force tribological tests. EV released under conditions constituted several lipid bilayers surrounding a viscous inner core. This "gel-in" vesicular structure...
Abstract Two florescent xanthene‐cyanamide lysosomal trackers emitting strongly at ∼525 nm were prepared from fluorescein and rhodol methyl esters in microwave‐assisted reactions. Both forms named “off” (nonfluorescent lactam) “on” (strongly fluorescent ring‐opened amide) have been comprehensively characterized out by using a combination of NMR spectroscopy, X‐ray analysis, fluorimetry confocal microscopy. Known rhodamines bearing electron‐withdrawing groups (EWGs) exhibit an equilibrium...