A5040003778- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Ocular Oncology and Treatments
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Protease and Inhibitor Mechanisms
- Click Chemistry and Applications
- Retinal Development and Disorders
- Cell Image Analysis Techniques
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Lanthanide and Transition Metal Complexes
- Cancer, Hypoxia, and Metabolism
- Molecular Sensors and Ion Detection
- Electron Spin Resonance Studies
- Ocular Diseases and Behçet’s Syndrome
- Galectins and Cancer Biology
- Lymphatic System and Diseases
- Angiogenesis and VEGF in Cancer
- Cell death mechanisms and regulation
- Connective tissue disorders research
- Metal-Catalyzed Oxygenation Mechanisms
- Cytokine Signaling Pathways and Interactions
Centre National de la Recherche Scientifique
2013-2023
Inserm
2014-2023
Institut Curie
2014-2023
Université Paris-Sud
2013-2023
Université Paris-Saclay
2011-2023
Université Paris Sciences et Lettres
2015-2022
Centre Hospitalier d'Orsay
2015-2022
Laboratoire d’Imagerie Biomédicale
2020
Directorate-General Joint Research Centre
2015
Université Toulouse III - Paul Sabatier
2012-2014
In order to avoid side effects at the time of cancer eradication patients, selectivity treatments has become strategic importance. case photodynamic therapy (PDT), two-photon absorption combined with active targeting tumors could allow both spatial and chemical selectivity. this context, we present synthesis, spectroscopic, biological properties a series porphyrin-triphenylamine hybrids excellent singlet oxygen production capacities good absorption.
In the most common primary brain tumors, malignant glioma cells invade extracellular matrix (ECM) and proliferate rapidly in cerebral tissue, which is mainly composed of hyaluronan (HA) along with elastin present basement membrane blood vessels. To determine role ECM components invasive capacity cell lines, we developed a 3-D cell-culture system, based on hydrogel HA can be coreticulated kappa-elastin (HA-kappaE). Using this invasiveness from four lines was dramatically increased by presence...
Abstract We have developed a straightforward synthetic pathway to set of six photoactivatable G‐quadruplex ligands with validated G4‐binding motif (the bisquinolinium pyridodicarboxamide PDC‐360A) tethered through various spacers two different photo‐cross‐linking groups: benzophenone and an aryl azide. The high quadruplex‐versus‐duplex selectivity the PDC core was retained in new derivatives resulted selective alkylation well‐known G‐quadruplexes (human telomeric G4 oncogene promoter c‐myc...
Abstract G‐Quadruplex(es) (G4) are noncanonical nucleic‐acid structures found in guanine‐rich sequences. They can be targeted with small molecules (G4 ligands) acting as reporters, for tracking both vitro and cells. We explored the cellular localization of PhenDC 3 , one most powerful G4 ligands, by synthesizing two clickable azide alkyne derivatives (PhenDC ‐alk, ‐az) labeling them situ corresponding Cy5 click partners. A careful comparison results obtained copper‐based CuAAC copper‐free...
The study of Mn-based superoxide dismutase mimic conjugated with a multimodal Re-probe in cellular model oxidative stress revealed that its bioactivity is associated accumulation at the mitochondria.
Abstract We have developed a straightforward synthetic pathway to set of six photoactivatable G‐quadruplex ligands with validated G4‐binding motif (the bisquinolinium pyridodicarboxamide PDC‐360A) tethered through various spacers two different photo‐cross‐linking groups: benzophenone and an aryl azide. The high quadruplex‐versus‐duplex selectivity the PDC core was retained in new derivatives resulted selective alkylation well‐known G‐quadruplexes (human telomeric G4 oncogene promoter c‐myc...
Bis-naphthalene macrocycles bind to abasic sites in DNA, leading efficient inhibition of their cleavage by human AP endonuclease 1 (APE1).
Interleukin-6 (IL-6) and its soluble receptor (sIL-6R) are major factors for maintenance expansion of hematopoietic stem cells (HSCs). Sensitivity HSCs to IL-6 has been previously studied, in part by measuring the expression IL-6R on membrane (mIL-6R). Several studies have described regulation cell surface several cytokines, but role glycoprotein 130 activation not yet investigated. In this study, CD133(+) were purified from adult peripheral blood precultured absence or presence...
A promising photosensitiser, which exhibits extremely suitable properties for photodynamic applications is described.
Triphenylamine (TP) derivatives such as two-branch cationic vinylbenzimidazolium triphenylamine TP-2Bzim are promising turn-on fluorescent probes suitable for two-photon imaging, labelling mitochondria in live cells. Here, we designed two bimodal X-ray fluorescence imaging. The conjugation of the TP core with a rhenium tricarbonyl moiety TP-RePyta probe altered localisation cells from to lysosomes. introduction bromine on generated TP-Br retaining good photophysical properties and influence...
An overexpression of MRC2 and CD209 mannose receptors was revealed in retinoblastoma antibodies against these were grafted to multifunctional nanoparticles for targeting imaging photodynamic therapy.
Because retinoblastoma therapies have many adverse effects, new approaches must be developed and evaluated on animal models. We describe orthotopic xenograft models of using different strains mice, suitable for this purpose.Human tumors were established immunodeficient mice by subcutaneous engraftment from enucleated eyes. The model was obtained subretinal injections suspension cells into the right eye (Swiss-nude, severe combined immunodeficiency [SCID]) immunocompetent (C57BL/6N,...
The aim of the study was to assess efficacy a treatment protocol that combines photodynamic therapy (PDT) and nitroglycerin (NG) on human retinoblastoma tumors xenografted mice. We aimed increase PDT efficiency (in our least treatment-responsive line) with better PS delivery tumor generated by NG, which is known dilate vessels enhance permeability retention macromolecules in solid tumors.In vivo follow-up therapeutic effects performed sodium MRI, directly monitors variations concentrations...
Abstract G‐Quadruplex(es) (G4) are noncanonical nucleic‐acid structures found in guanine‐rich sequences. They can be targeted with small molecules (G4 ligands) acting as reporters, for tracking both vitro and cells. We explored the cellular localization of PhenDC 3 , one most powerful G4 ligands, by synthesizing two clickable azide alkyne derivatives (PhenDC ‐alk, ‐az) labeling them situ corresponding Cy5 click partners. A careful comparison results obtained copper‐based CuAAC copper‐free...
The design of a dendrimeric-like diglycerol-tetrasubstituted Zn ( II ) phthalocyanine resulted in remarkably water-soluble compound due to the presence 16 hydroxyls. Several parameters relevant evaluate photodynamic efficiency potentiel photosensitizer such as: aggregation behavior, fluorescence properties, singlet oxygen generation, binding carrier protein model (Bovine Serum Albumin) and partition coefficient have been measured. Biocompatibility was demonstrated by dark cytotoxicity vitro...