A5103186887- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Radiation Therapy and Dosimetry
- Boron Compounds in Chemistry
- Advanced NMR Techniques and Applications
- NMR spectroscopy and applications
- Chemical Reactions and Isotopes
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Ocular Oncology and Treatments
- DNA Repair Mechanisms
- Computational Drug Discovery Methods
- Electron Spin Resonance Studies
- Science, Research, and Medicine
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Erythrocyte Function and Pathophysiology
- Genetics and Neurodevelopmental Disorders
- Ocular Diseases and Behçet’s Syndrome
- Autism Spectrum Disorder Research
- Protein Structure and Dynamics
Université Paris-Sud
2010-2023
Inserm
2010-2023
Institut Curie
2010-2023
Université Paris-Saclay
2011-2023
Centre National de la Recherche Scientifique
2016-2023
Centre Hospitalier d'Orsay
2022
Université Paris Sciences et Lettres
2018-2020
Memorial Sloan Kettering Cancer Center
2009-2016
Medico
2013
Université Toulouse III - Paul Sabatier
2012
In vivo knowledge of the spatial distribution viable, necrotic, and hypoxic areas can provide prognostic information about risk developing metastases regional radiation sensitivity may be used potentially for localized dose escalation in treatment. this study, multimodality magnetic resonance imaging (MRI) positron emission tomography (PET) using stereotactic fiduciary markers Dunning R3327AT prostate tumor were performed, focusing on relationship between dynamic contrast-enhanced (DCE) MRI...
Abstract Inhibition of tumor angiogenesis is a promising approach in cancer treatment. The purpose this study was to evaluate the vascular response human lung xenografts vivo RO0281501, an inhibitor tyrosine kinase receptors, including endothelial growth factor receptor 2, fibroblast receptor, and platelet-derived using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Human non–small cell carcinoma (H460a) grown s.c. athymic nu/nu mice were treated p.o. with antiangiogenic...
Longitudinal studies of lactate MRSI and dynamic contrast‐enhanced MRI were performed at 4.7 T in two prostate tumor models grown rats, Dunning R3327‐AT (AT) R3327‐H (H), to determine the potential perfusion/permeability parameter Ak ep as markers aggressiveness. Subcutaneous AT ( n = 12) H 6) tumors studied different volumes between 100 2900 mm 3 (Groups 1–5). Lactate concentration was determined using selective multiple quantum coherence with phantom substitution method. Tumor enhancement...
Abstract 17‐Allylamino, 17‐demethoxygeldanamycin (17‐AAG), an effective inhibitor of the heat shock protein hsp90, preferentially inhibiting tumor hsp90 compared to from normal cells, has shown promising results against several cancers, including hormone‐resistant prostate cancer. Levels oncogenic proteins critical growth and progression, such as androgen receptor HER2/ neu , were reduced 4 h post 17‐allylamino, treatment. Posttreatment metabolic changes have also been observed in cell...
The aim of the study was to assess efficacy a treatment protocol that combines photodynamic therapy (PDT) and nitroglycerin (NG) on human retinoblastoma tumors xenografted mice. We aimed increase PDT efficiency (in our least treatment-responsive line) with better PS delivery tumor generated by NG, which is known dilate vessels enhance permeability retention macromolecules in solid tumors.In vivo follow-up therapeutic effects performed sodium MRI, directly monitors variations concentrations...
Medulloblastoma is an important cause of mortality and morbidity in pediatric oncology. Here, we investigated whether the DNA repair inhibitor, AsiDNA, could help address a significant unmet clinical need medulloblastoma care, by improving radiotherapy efficacy without increasing radiation-associated toxicity.To evaluate brain permeability AsiDNA upon systemic delivery, intraperitoneally injected fluorescence form models harboring tumors still development. Studies evaluated toxicity...
AbstractThe endothelin-1 antagonist, Atrasentan (ABT-627) was used to modify perfusion in the human tumor xenograft model, HT29, growing nude mice. produced a significant increase perfusion, as measured vivo by Gd-DTPA DCE-MRI. Changes hypoxia were assessed comparing binding of two tracers, pimonidazole and EF5 given before after administration. In vehicle-treated controls, distribution very similar. However, treatment associated with decreased uptake second tracer (EF5), relative first...