A5053856754- Health Promotion and Cardiovascular Prevention
- Nutritional Studies and Diet
- Health disparities and outcomes
- Blood Pressure and Hypertension Studies
- Global Public Health Policies and Epidemiology
- Health, Environment, Cognitive Aging
- SARS-CoV-2 and COVID-19 Research
- Global Cancer Incidence and Screening
- Cardiovascular Health and Risk Factors
- Public Health in Brazil
- T-cell and B-cell Immunology
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Diabetes Management and Education
- Respiratory viral infections research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Iron Metabolism and Disorders
- Healthcare Regulation
- Diabetes and associated disorders
- Hemoglobinopathies and Related Disorders
- Primary Care and Health Outcomes
- Global Health Workforce Issues
- Immune Cell Function and Interaction
- Birth, Development, and Health
National Institute of Health Dr. Ricardo Jorge
2016-2025
University of Lisbon
2019-2025
Ricardo (United Kingdom)
2021-2023
Escola Nacional de Saúde Pública
2023
Instituto Nacional de Saúde
2023
Instituto de Saúde
2021
Universidade Nova de Lisboa
2017-2020
Centro de Estudos em Psicologia da Saúde
2017-2018
Instituto Gulbenkian de Ciência
2004-2012
Icahn School of Medicine at Mount Sinai
2009
Abstract Background CD4 + CD25 regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic disease characterized by loss of tolerance to nuclear components significantly more frequent females. Results To investigate the involvement SLE pathogenesis, we determined frequency...
In Health Examination Surveys interview information is complemented with objective information, providing more accurate indicators than self-reported data. We report the study design, planning and implementation of first Portuguese Survey (INSEF).INSEF was a cross-sectional population-based representative at regional national level. Individuals aged between 25 74 years old, residing in Portugal were selected from health users' registry through multi-stage stratified probabilistic sampling....
Introduction: The aim of this study was to estimate and describe the prevalence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibodies (immunoglobulin M and/or immunoglobulin G) in Portugal May-July 2020.Material Methods: A cross-sectional seroepidemiological survey developed after peak first epidemic wave on a sample 2301 Portuguese residents, aged 1 year or older. Survey selected using two-stage stratified non-probability sampling design (quota sampling)....
During the autumn/winter respiratory syncytial virus (RSV) epidemics, bacterial co-infection is common and affects disease severity. We aimed to understand relationship between RSV-bacterial co-infections clinical severity since RSV seasonality change after COVID-19 pandemic. conducted a prospective, sentinel surveillance study at 20 sites in Portugal children under 2 years hospitalized with RSV, April 21 January 23. Effect of potentially pathogenic bacteria (PPB) on length hospitalization...
A osteoporose é uma doença metabólica óssea multifatorial caracterizada pela redução progressiva da densidade mineral e pelo aumento do risco de fraturas, especialmente em mulheres pós-menopausa homens idosos. Este estudo apresenta revisão literatura abrangente sobre os avanços no diagnóstico, tratamento manejo doença, abordando fatores risco, métodos diagnósticos intervenções terapêuticas. pesquisa foi conduzida bases dados como PubMed Scopus, considerando publicações entre 2014 2024,...
A Atenção Primária à Saúde (APS) busca um cuidado integral, considerando determinantes sociais e promovendo ações preventivas de promoção da saúde. Estratégia Família (ESF) é modelo fundamental nesse contexto, estruturado para fortalecer a participação comunitária aprimorar assistência. abordagem envolve planejamento, implementação avaliação que integram população no processo cuidado, garantindo maior resolutividade efetividade. Esta revisão sistemática analisou esses processos na ESF,...
Introduction: Due to the high number of people with post-stroke cognitive impairment, there is a growing need implement rehabilitation programs so that they can regain functionality. Objective: Identify available evidence on for stroke. Methodology: Integrative literature review, carried out EBSCOhost aggregator, predefined inclusion/exclusion criteria. Results: Six studies were included total 2327 identified. Cognitive categorized into in acute phase (inpatient, individual sessions);...
Oral health is a determinant for quality of life and preventive behaviours such as regular tooth brushing can reduce the risk wide spectrum oral diseases. Adopting increases likelihood being healthy be conditioned by demographic socio-economic factors.This study aims to describe hygiene in Portuguese population assess their association with sociodemographic socioeconomic factors.A cross-sectional epidemiologic was developed using data from first National Health Examination Survey. The target...
Integrated approaches to surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection are important for public health actions. The 2nd National Serological Survey (ISN2COVID-19) aimed characterize the extent SARS-CoV-2 and vaccine-induced response in Portuguese population following third epidemic wave launch vaccination campaign.A cross-sectional study was performed using data on 8463 1-79 years age, collected February March, 2021. IgM IgG (anti-nucleoprotein...
In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production with indiscriminable specificity, usually without ever acquiring the disease. We studied relations IgG autoantibody profiles and peripheral blood activated regulatory T-cells (aTregs), represented by CD4+CD25bright that were regularly 70–90% Foxp3+. found consistent positive correlations...
After the rapid spread of SARS-CoV-2 BA.5 Omicron lineage in Portugal, we developed a seroepidemiologic survey based on sample 3,825 residents. Results indicated that from April 27 through June 8, 2022, estimated seroprevalence nucleocapsid or spike IgG was 95.8%, which indicates high level protection.
Abstract Background In collaboration with six European public health agencies as part of the PANDEM-2 consortium, we have developed and validated a self-assessment tool that captures workforce capacities capabilities needed at institutional level within National Public Health Institutes (NPHIs) to deal emergencies. Methods The work carried out in this study included (i) review existing tools for assessment, (ii) focus group discussions interviews map experiences needs NPHI’s, (iii)...
Metabolic syndrome (MetS) is a cluster of conditions that occur together, increasing the risk heart disease, stroke and diabetes. Since pathways implicated in different diseases reveal surprising insights into shared genetic bases underlying apparently unrelated traits, we hypothesize there are common components involved clustering MetS traits. With aim identifying these components, have performed association study by integrating traits continuous score.A cross-sectional developed context...
Cardiovascular disease is an important cause of death and disability worldwide, hypertension responsible for at least 45% all deaths due to heart 51% stroke. This study aimed estimate describe the distribution prevalence, awareness, treatment control in Portuguese population 2015. A national survey using a representative sample 4911 individuals residing Portugal aged between 25 74 years was implemented. Trained nurses performed health interview physical examination, including blood pressure...
This study aims to estimate the associations between area-level deprivation and individual-level socio-economic factors, as well their interaction, with glycated haemoglobin (HbA1c ) levels.We conducted a gamma multilevel regression analysis using data from Portuguese National Health Examination Survey index built through factor analysis, at municipality level, census variables.Living in high material having low level of education were independently associated an increase 2.3% (95%...
Abstract IPEX is a rare X‐linked syndrome, with immune dysfunction, polyendocrinopathy and enteropathy. We describe an infant who died at the age of 11 months after developing eczema, severe diarrhoea, diabetes, hypothyroidism, thrombocytopenia four episodes septicaemia. Immunophenotyping peripheral blood 8 revealed normal CD3+ T, CD4+ T CD8+ cell numbers, low NK B cells. lymphocytes showed remarkably numbers percentages naïve cells high memory CD4 CD8 At autopsy, intense depletion in...
Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and course of influenza infection. However, it is not clear whether reported relates to infection severity. The aim this study was estimate hospitalization risk associated with in Influenza Like Illness (ILI) patients during H1N1 pandemic influenza.A case-control genetic performed, using nasopharyngeal/oropharyngeal swabs collected influenza. Laboratory diagnosis performed by...
This study aimed to compare self-reported and examination-based prevalence of hypertension hypercholesterolemia in Portugal 2015 identify factors associated with the measurement error self-reports.We used data from Portuguese National Health Examination Survey (n = 4911), that combines personal interview, blood collection and, physical examination. Sensitivity specificity were calculated. Poisson regression was estimate ratios (PRs) underreport according sex, age, socioeconomic status...