A5080690685- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Mathematical Biology Tumor Growth
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Cancer Cells and Metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Radiation Dose and Imaging
- Nuclear reactor physics and engineering
- Optimism, Hope, and Well-being
- Advances in Oncology and Radiotherapy
- Kidney Stones and Urolithiasis Treatments
- Dyeing and Modifying Textile Fibers
- Advanced Energy Technologies and Civil Engineering Innovations
- Cancer Research and Treatments
- Advanced X-ray and CT Imaging
- Advanced Materials and Semiconductor Technologies
- Optical measurement and interference techniques
Memorial Sloan Kettering Cancer Center
2014-2023
Aalborg University Hospital
2017
Washington University in St. Louis
2015
Dutch Cancer Society
2015
The Netherlands Cancer Institute
2015
Amsterdam UMC Location University of Amsterdam
2015
University of Missouri
2010-2012
Abstract Purpose: To demonstrate that a mathematical model can be used to quantitatively understand tumor cellular dynamics during course of radiotherapy and predict the likelihood local control as function dose treatment fractions. Experimental Design: We outcomes for early-stage, localized non–small cell lung cancer (NSCLC), by fitting mechanistic, dynamics-based probability assumes constant supply oxygen glucose. In addition standard radiobiological effects such repair sub-lethal damage...
A tumour control probability computational model for fractionated radiotherapy was developed, with the goal of incorporating fundamental interplay between hypoxia and proliferation, including reoxygenation over a course radiotherapy. The idea is that local delivery oxygen glucose limits amount proliferation metabolically-supported cell survival sub-volume can support. has three compartments: proliferating compartment cells receiving glucose; an intermediate, metabolically-active highly...
Abstract Urinary stone size is key in determining treatment. Although computed tomography (CT) scans are widely used for diagnosing urinary stones, measurements of obtained from CT images may be inaccurate compared to actual size. Twenty-four phantoms were 3D printed at three densities (100, 1000, and 3000 Hounsfield units [HU]) eight sizes. the taken. Nineteen radiologists 33 emergency physicians two institutions measured sizes on using mediastinum bone settings. An automated algorithm...
Significance Currently, there are no therapies available to mitigate intestinal damage after radiation injury. Efforts study and design new hampered by a lack of models that can be readily adopted therapeutic targets. Here we describe preclinical platform evaluate countermeasures against injury in vivo mouse model permits inducible reversible gene suppression following exposure. We demonstrate transient Apc stimulates regeneration mitigates lethality injury, thus validating pulsed Wnt...
Monte Carlo simulations have been used for calculating the energy deposition of beta particles in depletion region a silicon carbide (SiC) betavoltaic cell along with corresponding theoretical efficiencies. Three codes were study: GEANT4, PENELOPE, and MCNPX. These to examine transportation from 90Y, 90Sr, 35S. Both average each source entire spectrum modeled maximum both spherical slab geometry. A simulated was added postprocessing containing deposited per micrometer. The calculated...
The workload for shielding purposes of modern linear accelerators (linacs) consists primary and scatter radiation which depends on the dose delivered to isocenter (cGy) leakage monitor units (MUs). In this study, we report 10 treatment vaults in terms (cGy), (MUs), number sessions (Txs), as well as, use factors (U) modulation (CI) different techniques. survey was performed years between 2006 2015 included 16 machines represent generations Varian (6EX, 600C, 2100C, 2100EX, TrueBeam) operating...
Radiobiological models of tumour control probability (TCP) can be personalized using imaging data. We propose an extension to a voxel-level radiobiological TCP model in order describe patient-specific differences and intra-tumour heterogeneity. In the proposed model, shrinkage is described by means novel kinetic Monte Carlo method for inter-voxel cell migration deformation. The captures spatiotemporal evolution at voxel level, designed take data as input. To test performance three...
High fluorodeoxyglucose positron emission tomography (FDG-PET) uptake in tumors has often been correlated with increasing local failure and shorter overall survival, but the radiobiological mechanisms of this are unclear. We explore relationship between FDG-PET tumor radioresistance using a mechanistic model that considers cellular status as function microenvironmental conditions, including proliferating cells access to oxygen glucose, metabolically active glucose not oxygen, severely...
Although spatially precise systems are now available for small-animal irradiations, there currently limited software tools treatment planning such irradiations. We report on the adaptation, commissioning, and evaluation of a 3-dimensional system use with irradiation system. The 225-kV X-ray beam X-RAD 225Cx microirradiator (Precision X-Ray) was commissioned using both ion-chamber radiochromic film 10 different collimators ranging in field size from 1 mm diameter to 40 × 2 . A clinical...
Background: Proton dose distributions are sensitive to range uncertainties, resulting in margins added ensure adequate tumor control probability (TCP). We investigated the required margin and shape needed TCP, for representative cell clinical target volume (CTV). Material methods: A mechanistic response model, validated lung tumors, was used estimate TCP. The distribution ( ρ ) assumed decrease exponentially CTV with decay parameter λ toward outer border xCTVmax ). It if a gradual fall-off...
Colorectal liver metastases (CLMs) represent a radioresistant histology. We aimed to investigate CLM radiation therapy (RT) outcomes and explore the association with treatment parameters.
Purpose: Current commercially available small animal irradiators provide limited software tools for treatment planning. We report on the implementation of an in-house planning system, Metropolis, micro-irradiator and compare its capabilities with those vendor-supplied TPS(XRAD). Methods: The 225 kV beam was commissioned using both ion chamber radiographic film (EBT3). Dose calculation in Metropolis verified by comparing measured dose phantom. Starting from a 3D CT image tumor-bearing mouse,...
Purpose/Objective(s)We previously modeled clinical proton local control data of early-stage lung cancer using a simulation model based on an energy budget. The fitted modeling results suggest that therapy is nearly independent hypoxia reoxygenation which key process to photon results. In this work, we investigated the effect variable levels efficacy compared photon, in terms RBE, for various fractionation schedules, searching optimal treatment option.Materials/MethodsModel simulations were...
Each year, 170,000 cancer patients in the United States develop brain metastases. Many of them present with multiple small lesions. Historically, Linac-based stereotactic radiosurgery (SRS) was used to treat single solitary metastasis a diameter less than 3.0 cm, while whole radiation therapy (WBRT) metastases mainly as palliative therapy. Evidence-based practices reveal that WBRT results poor treatment outcomes, high local recurrence rates, decreased cognitive function, and even onset...
Purpose: Concurrent chemo-radiation therapy (CCRT) has become a more common cancer treatment option with better tumor control rate for several sites, including head and neck lung cancer. In this work, possible optimal chemotherapy schedules were investigated by implementing cell-kill into response model of RT. Methods: The effect been added published (Jeong et al., PMB (2013) 58:4897), in which the to RT can be simulated effects hypoxia proliferation. Based on two-compartment pharmacokinetic...
Purpose: The radiobiological understanding of SBRT is controversial. In this work, we modeled outcomes based on a previously published tumor control probability model, that incorporates hypoxia, proliferation and cell-cycle effects, in order to understand if non-traditional factors must be invoked the efficacy single multiple fraction SBRT. Methods: We extracted cohorts from Mehta et al. (PRO (2012) 2:288) with easily identifiable fractionation parameters commensurate outcome prescription...