A5069121068- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Metal-Catalyzed Oxygenation Mechanisms
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Porphyrin and Phthalocyanine Chemistry
- Electron Spin Resonance Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Carbohydrate Chemistry and Synthesis
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Crystallography and molecular interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Electrochemical Analysis and Applications
- Molecular Sensors and Ion Detection
- Trace Elements in Health
- Nanoplatforms for cancer theranostics
- Enzyme Structure and Function
- Mass Spectrometry Techniques and Applications
- CO2 Reduction Techniques and Catalysts
- Photosynthetic Processes and Mechanisms
- Cancer Treatment and Pharmacology
- Protein Structure and Dynamics
- Analytical chemistry methods development
Laboratoire des Biomolécules
2016-2025
Sorbonne Université
2016-2025
Université Paris Sciences et Lettres
2015-2025
Centre National de la Recherche Scientifique
2016-2025
École Normale Supérieure - PSL
2015-2025
Centre National pour la Recherche Scientifique et Technique (CNRST)
2025
Laboratoire de Physique de l'ENS
2012-2024
Institut de Chimie
1998-2023
Sorbonne Paris Cité
2014-2023
Institut de Recherche de Chimie Paris
2018-2023
Some like it hot! The photothermally induced resonance technique, in which an AFM microscope is coupled to a tunable pulsed IR laser, allows mapping and gives access local spectra at the subcellular level. A metal–carbonyl compound was internalized cells detected cell nucleus thanks its signature. spectrum showed characteristic bands of {Re(CO)3} unit. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or...
The electrochemical reduction of phenylazide or phenylacetylene diazonium salts leads to the grafting azido ethynyl groups onto surface carbon electrodes. In presence copper(I) catalyst, these azide- alkyne-modified surfaces react efficiently and rapidly with compounds bearing an acetylene azide function, thus forming a covalent 1,2,3-triazole linkage by means click chemistry. This was illustrated coupling ferrocenes functionalized group biomolecule biotin terminated group.
Overproduction of reactive oxygen species and antioxidant superoxide dismutases (SOD1, SOD2) dysregulation contribute to chronic inflammation such as generated in inflammatory bowel diseases (IBD). A kinetic redox shotgun proteomic strategy (OcSILAC for Oxidized cysteine Stable Isotope Labelling by Amino acids Cell culture) was used explore the lipopolysaccharide (LPS) effects including LPS‐induced oxidation cascades on a dedicated intestinal epithelial cell line (HT29‐MD2) together with...
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis represent a global health issue as prevalence of 1% is expected in the western world by end this decade. These idiseases are associated with high oxidative stress that induces inflammatory pathways severely damages gut tissues. IBD patients suffer from antioxidant defenses weakening, through, for instance, an impaired activity superoxide dismutases (SOD) — catalyze dismutation or other endogenous enzymes...
A rhenium tris-carbonyl derivative has been designed to couple infrared and luminescent detection in cells. Both spectroscopies are consistent with one another; they point out the reliability of present SCoMPI (for Single Core Multimodal Probe for Imaging) bimodal imaging unambiguously indicate a localization at Golgi apparatus MDA-MB-231 breast cancer
Octahedral d6 low-spin Re(I) tricarbonyl complexes are of considerable interest as noninvasive imaging probes and have been deeply studied owing to their biological stability, low toxicity, large Stokes shifts, long luminescence lifetimes. We reported recently the bimodal IR a complex with Pyta ligand (4-(2-pyridyl)-1,2,3-triazole) in cells labeled such metal–carbonyl SCoMPIs for single-core multimodal imaging. unique photophysical properties allowing unequivocal detection but also present...
3-Methoxy-17α-ethynylestradiol or mestranol is a prodrug for ethynylestradiol and the estrogen component of some oral contraceptive formulations. We demonstrate here that single core multimodal probe imaging – SCoMPI can be efficiently grafted onto allowing its tracking in two breast cancer cell lines, MDA-MB-231 MCF-7 fixed cells. Correlative studies based on luminescence (synchrotron UV spectromicroscopy, wide field confocal fluorescence microscopies) vibrational (AFMIR, synchrotron FTIR...
Abstract Rhenium triscarbonyl complexes fac ‐[Re(CO) 3 (N^N)] with appropriate ancillary N^N ligands are relevant for fluorescent bio‐imaging. Recently, we have shown that [Re(CO) ] cores can also be efficiently mapped inside cells using their IR signature and they thus used in a bimodal approach. To describe them coined the term SCoMPIs single‐core multimodal probes imaging. In context of use these bio‐imaging, questions cellular uptake cytotoxicity critical. We report here series compounds...
A new series of six Schiff bases derived from S-methyldithiocarbazate (SMDTC) and S-benzyldithiocarbazate (SBDTC) with methyl levulinate (SMML, SBML), levulinic acid (SMLA, SBLA), 4-carboxybenzaldehyde (SM4CB, SB4CB) were reacted copper(II), producing complexes general formula ML2 (M = Cu(II), L ligand). All compounds characterized using established physicochemical spectroscopic methods. Crystal structures determined for three SBML, SBLA) two Cu(II) (Cu(SMML)2 Cu(SMLA)2). In order to provide...
The crystal structure of an infinite inorganic chain consisting MnII and N-centered tripodal ligand N,N-(2-pyridylmethyl)[(1-methylimidazol-2-yl)-methyl]glycinate is presented. It exhibits a chiral helical with pitch two monomeric units (each unit containing one Mn atom). Each manganese connected to its neighbor through carboxylate bridge in syn-anti geometry. Around each center, carboxylates bind cis This peculiar bridging geometry (syn-anticis) provides broken-line chain, running zig-zag...
The crystal structure of an inorganic linear polymer consisting Mn(II) and N-centered tripodal ligand N,N-bis(2-(6-methyl)pyridylmethyl)glycinate is presented (1, C(16)H(20)N(3)O(3)F(6)P(1)Mn(1), a = 9.993(2) A, b 13.285(3) c 16.040(3) orthorhombic, Pnam, Z 4). polymeric ensured by carboxylato ligands connecting two in rather rare syn-anti geometry. magnetic properties this infinite chain have been investigated, together with the dimeric compound (3) from closely related...
Abstract Two crystal structures are described in this article: (a) the structure of a monomeric Mn II complex with tridentate N ‐centered 3 ligand tris[(1‐methyl‐2‐imidazolyl)methyl]amine (TMIMA) ([Mn 2 ] 2+ ); and (b) III O 2‐{[(1‐methyl‐2‐imidazolyl)methyl]amino}phenolate (PI – ) (PI) + ( 5 ). The latter was isolated both state, although only crystals were successfully grown. They part series complexes prepared as SOD mimics, namely [Mn(BMPG)(H O)] {BMPG = ,...
A series of [Re(N^N)(CO)3(X)] (N^N = diimine and X halide) complexes based on 4-(2-pyridyl)-1,2,3-triazole (pyta) 1-(2-pyridyl)-1,2,3-triazole (tapy) ligands have been prepared electrochemically characterized. The first ligand-based reduction process is shown to be highly sensitive the nature isomer as well substituents pyridyl ring, with peak potential changing by up 700 mV. abilities this class catalyze electroreduction photoreduction CO2 were assessed for time. It found that only Re pyta...
Overproduction of reactive oxygen species and antioxidant superoxide dismutases (SOD1, SOD2) dysregulation contribute to chronic inflammation such as generated in inflammatory bowel diseases (IBD). A kinetic redox shotgun proteomic strategy (OcSILAC for Oxidized cysteine Stable Isotope Labelling by Amino acids Cell culture) was used explore the lipopolysaccharide (LPS) effects including LPS‐induced oxidation cascades on a dedicated intestinal epithelial cell line (HT29‐MD2) together with...
Two new Fe(II) compounds based on a pyridine-triazole ligand with NCS- co-ligand were synthesized as thermodynamic (1) and kinetic (2) products. Single crystal X-Ray diffraction evidenced that those are...
This symposium is the 6th Paris Sciences & Lettres (PSL) Chemical Biology meeting (2015, 2016, 2019, 2023, 2024, 2025) being held at Institut Curie. initiative originally started in 2013 de Chimie des Substances Naturelles (ICSN) Gif‐sur‐Yvette and was mostly focused on organic synthesis. It then exported Curie to cover a larger scope, before becoming official French meeting. year, around 200 participants had opportunity meet world leaders chemistry biology who described their latest...
Metal complexes are increasingly used as metallo-probes or metallo-drugs. Their characterization in cellular biological environments poses specific challenges related to possible decoordination, metal exchange, fixation of additional ligands, precipitation. These phenomena can hardly be foreseen and it is important integrate the design these with their study cells, from cells (quantification, speciation, integrity complex location) bioactivity. Redox homeostasis oxidative stress strongly...