A5075694197- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Asymmetric Synthesis and Catalysis
- Magnetism in coordination complexes
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Metal-Catalyzed Oxygenation Mechanisms
- Metal complexes synthesis and properties
- Synthetic Organic Chemistry Methods
- Porphyrin and Phthalocyanine Chemistry
- Lanthanide and Transition Metal Complexes
- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Radical Photochemical Reactions
- Carbohydrate Chemistry and Synthesis
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Fluorine in Organic Chemistry
- Catalytic Cross-Coupling Reactions
- Carbon dioxide utilization in catalysis
- Click Chemistry and Applications
- Molecular spectroscopy and chirality
- Chemical synthesis and alkaloids
- Photochromic and Fluorescence Chemistry
Université Paris-Saclay
2016-2025
Institut de Chimie Moléculaire et des Matériaux d'Orsay
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Université Paris Cité
2008-2023
Université Paris-Sud
2012-2022
Catalyse
2008-2022
Centre Hospitalier d'Orsay
2014-2021
Robert Bosch (Germany)
2021
International Council on Mining and Metals
2013-2019
Laboratoire de Synthèse Organique
2007-2019
We report the use of electrochemistry to perform a direct oxidative dearomatization indoles leading 2,3-dialkoxy or 2,3-diazido indolines under undivided conditions at constant current. This operationally simple electro-oxidative procedure avoids an external oxidant and displays excellent functional group compatibility. The formation two C-O C-N bonds is believed arise from oxidation into radical cation intermediates.
Abstract Inspired by nature's orchestra of chemical subtleties to activate and reduce CO 2 , we have developed a family iron porphyrin derivatives in which introduced urea groups functioning as multipoint hydrogen‐bonding pillars on the periphery porphyrinic ring. This structure closely resembles hydrogen‐bond stabilization scheme carbon dioxide (CO ) adduct monoxide dehydrogenase (CODH). We found that such changes second coordination sphere significantly lowered overpotential for reduction...
With a little help from some friends: the aid of HClO4 as proton and BPh4− electron source, Fe complex pentadentate pyridyl-appended cyclam ligand can activate dioxygen to yield corresponding oxoiron(IV) (see scheme; TMC-py=1-(2′-pyridylmethyl)-4,8,11-trimethyl-1,4,8,11-tetraazacyclotetradecane; C gray, magenta, N blue, O red). This transformation is proposed occur via hydroperoxoiron(III) intermediate. Supporting information for this article available on WWW under...
The magnetic anisotropy of two pentacoordinate trigonal bipyramidal (C3v symmetry) Co(II) complexes, [Co(Me6tren)Cl]ClO4 (1) and [Co(Me6tren)Br]Br (2), was investigated analysed by studies, high field multifrequency electron paramagnetic resonance (EPR) ab initio calculations. Negative D parameters expressing an Ising-type (easy axis magnetization) were found experimentally for both complexes. Calculations led to values very close the experimental ones, which allows a robust rationalisation...
This paper reports the experimental and theoretical investigations of two trigonal bipyramidal Ni(II) complexes, [Ni(Me(6)tren)Cl](ClO(4)) (1) [Ni(Me(6)tren)Br](Br) (2). High-field, high-frequency electron paramagnetic resonance spectroscopy performed on a single crystal 1 shows giant uniaxial magnetic anisotropy with an D(expt) value (energy difference between M(s) = ± 0 components ground spin state S 1) estimated to be -120 -180 cm(-1). The study that, for ideally complex, orbital...
The Gly-His-Lys (GHK) peptide and the Asp-Ala-His-Lys (DAHK) sequences are naturally occurring high-affinity copper(II) chelators found in blood plasma hence of biological interest. A structural study copper complexes these peptides was conducted solid state solution by determining their X-ray structures, using a large range spectroscopies, including EPR HYSCORE (hyperfine sub-level correlation), absorption (1)H (13)C NMR spectroscopy. results indicate that structures [Cu(II)(DAHK)] similar...
Abstract Inspired by the biogenetic synthesis of benzofuroindoline‐containing natural products, we designed an oxidative coupling between phenol and N ‐acetyl indoles. This straightforward direct radical process, mediated 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone FeCl 3 allowed regioselective benzofuro[3,2‐b]indolines, whose structure is found in product phalarine.
Two relaxation processes of the magnetization in an antiferromagnetically coupled Dy<sub>2</sub> metallacrown-based complex.
Mechanofluorochromic molecular materials display a change in fluorescence color through mechanical stress. Complex structure-property relationships both the crystalline and amorphous phases of these govern presence strength this behavior, which is usually deemed result mechanically induced phase transition. However, precise nature emitting species each often matter speculation, resulting from experimental data that are difficult to interpret, lack an acceptable theoretical model capable...
Aniline derivatives are frequently encountered in molecules of industrial relevance such as dyes or antioxidants, which make the development synthetic methods for functionalization these privileged structures highly sought-after. A general protocol hydroarylation electronically diverse alkenes with anilines would be ideal to provide densely functionalized compounds. However, this transformation has been underexplored compared more traditional unactivated because significant challenges...
Abstract The manipulation of the second coordination sphere for improving electrocatalytic CO 2 reduction has led to breakthroughs with hydrogen bonding, local proton source, or electrostatic effects. We have developed two atropisomers an iron porphyrin complex urea functions acting as multiple hydrogen‐bonding tweezers lock metal‐bound in a similar fashion found carbon monoxide dehydrogenase (CODH) enzyme. αα topological isomer groups on same side provides stronger binding affinity tether...
At the core of carbon monoxide dehydrogenase (CODH) active site two metal ions together with hydrogen bonding scheme from amino acids orchestrate interconversion between CO2 and CO. We have designed a molecular catalyst implementing bimetallic iron complex an embarked second coordination sphere multi-point hydrogen-bonding interactions. found that, when immobilized on paper electrode, dinuclear enhances up to four fold heterogeneous reduction CO in water improved selectivity stability...
Crystallography at subatomic resolution permits the observation and measurement of non-spherical character atomic electron density. Charge density studies are being performed on molecules increasing size. The MOPRO least-squares refinement software has thus been developed, by extensive modifications program MOLLY , for protein supramolecular chemistry applications. computation times long because large number reflections complexity multipolar model density; structure factor derivative...
A family of terpyridine metallo-organic complexes has been designed and its recognition properties G-quadruplex-DNA investigated. The series combines easy synthetic access good affinity–selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry metal center strongly governs ability compounds to discriminate quadruplex from duplex-DNA.
Wrapper's delight: Clathrochelate complexes, in which the metal center is wrapped a close-knit macrobicyclic ligand, are often considered to be deprived of chemical reactivity. Boron-capped cobalt tris(glyoximato) complexes show catalytic activity reduction acids acetonitrile at potentials as small −0.5 V versus SCE. Alteration ligand substituents allows for tuning their electrochemical reactivity (see structure: red ball Co, grey C, purple B, blue N, O, green X).
New chiral binaphthylamido yttrium and ytterbium ate complexes with lithium potassium counterions have been synthesised characterised. X-ray structures obtained for [Li(thf)4][Ln{(R)-C20H12(NC5H9)2}2] (Ln=Yb, Y) [K(thf)5][Yb{(R)-C20H12(NCH2CMe3)2}2] as isostructural complexes. The efficiency of these the enantioselective intramolecular hydroamination was examined. [Li(thf)4][Yb{(R)-C20H12(NC5H9)2}2] afforded highest enantiomeric excess (up to 87 %) synthesis a spiropyrrolidine, while...
IRONic electrophilic indoles! The C3-regioselective hydroarylation of N-acetyl indoles with aromatic nucleophiles mediated by FeCl(3) features a rare example the reactivity indole core in Friedel-Crafts reaction. This umpolung allows us straightforward access to tetracyclic benzofuroindoline motif found natural product diazonamide A, which is potent antitumor agent.
The intermediacy of gold acetylides in the gold(I)-catalyzed cycloisomerization enynes was questioned. While dinuclear complexes are observed under electrospray ionization conditions, solution reactivity also leads to conclusion their high affinity for second coordination a moiety, leading complexes. However, involvement and corresponding diaurated species elementary steps mechanisms appears unlikely.
Octahedral d6 low-spin Re(I) tricarbonyl complexes are of considerable interest as noninvasive imaging probes and have been deeply studied owing to their biological stability, low toxicity, large Stokes shifts, long luminescence lifetimes. We reported recently the bimodal IR a complex with Pyta ligand (4-(2-pyridyl)-1,2,3-triazole) in cells labeled such metal–carbonyl SCoMPIs for single-core multimodal imaging. unique photophysical properties allowing unequivocal detection but also present...
In control! N-alkoxybicyclolactams derived from the ring-rearrangement metathesis of nitroso Diels–Alder cycloadducts were subjected to successive addition two nucleophiles yield substituted piperidine or pyrrolidine precursors with good excellent stereoselectivity. The relative configuration newly formed stereocenter can be controlled by order nucleophiles. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...
An open and closed case: The photochromic bisthienylethene BTTE based on benzobisthiadiazole exhibits excellent performance in both solution single crystals (see picture). shows thermal stability, which is comparable to the widely known five-membered hexafluorocyclopentene-based counterpart. Detailed facts of importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please...
Abstract A challenge in molecular spintronics is to control the magnetic coupling between molecules and electrodes build efficient devices. Here we show that nature of ion anchored metal complexes highly impacts exchange with substrates. Surface anchoring alters anisotropy cobalt(II)-containing complex (Co(Pyipa) 2 ), results blocking its magnetization due presence a hysteresis loop. In contrast, no loop observed isostructural nickel(II)-containing (Ni(Pyipa) ). Through XMCD experiments...
Mechano-CPL effect: chiral difluoro-boron β-diketonate complexes show concomitant changes of emission color as well solid state chiroptical properties upon mechanical stimulation.
Abstract The interactions of three cationic distyryl dyes, namely 2,4‐bis(4‐dimethylaminostyryl)‐1‐methylpyridinium ( 1 a ), its derivative with quaternary aminoalkyl chain b and the symmetric 2,6‐bis(4‐dimethylaminostyryl)‐1‐methylpyridinium 2 several quadruplex duplex nucleic acids were studied aim to establish influence geometry dyes on their DNA‐binding DNA‐probing properties. results from spectrofluorimetric titrations thermal denaturation experiments provide evidence that asymmetric...