A5025174604- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Lichen and fungal ecology
- Synthetic Organic Chemistry Methods
- Computational Drug Discovery Methods
- Phytochemical Studies and Bioactivities
- Plant biochemistry and biosynthesis
- Phytochemistry and Bioactivity Studies
- Bryophyte Studies and Records
- Botany and Plant Ecology Studies
- Analytical Chemistry and Chromatography
- Molecular spectroscopy and chirality
- Berberine and alkaloids research
- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Radical Photochemical Reactions
Université Paris-Saclay
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Institut de Chimie des Substances Naturelles
2013-2025
Laboratoire des Biomolécules
2016-2024
Université Paris-Sud
2014-2021
Laboratoire de Chémo-biologie synthétique et thérapeutique
2019
Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
2016-2018
University of Zurich
2017
Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
2014-2015
Institut Galien Paris-Saclay
2015
The Zika virus (ZIKV), an emerging orthoflavivirus, presents a significant public health threat due to its rapid dissemination and association with severe neurological complications. urgent need for effective antiviral agents has driven research into novel bioactive compounds derived from unique natural sources. Microorganisms inhabiting extreme environments are particularly promising such discoveries their potential produce metabolites. In this study, we explored microorganisms the...
Abstract While analytical techniques in natural products research massively shifted to liquid chromatography-mass spectrometry, lichen chemistry remains reliant on limited methods, Thin Layer Chromatography being the gold standard. To meet modern standards of metabolomics within lichenochemistry, we announce publication an open access MS/MS library with 250 metabolites, coined LDB for Lichen DataBase, providing a comprehensive coverage chemodiversity. These were donated by Berlin Garden and...
Two new acridone alkaloids, chlorospermines A and B (1 2), were isolated from the stem bark of Glycosmis chlorosperma, together with known atalaphyllidine (3) acrifoline (4), by means bioguided isolation using an in vitro enzyme assay against DYRK1A. Acrifoline (4) to a lesser extent chlorospermine (2) showed significant inhibiting activity on DYRK1A IC50's 0.075, 5.7, 2.2 μM, respectively. Their selectivity profile was evaluated panel various kinases, molecular docking calculations provided...
Three new monoterpene indole alkaloids (1-3) have been isolated from the bark of Geissospermum laeve, together with known (-)-leuconolam (4), geissolosimine (5), and geissospermine (6). The structures 1-3 were elucidated by analysis their HRMS NMR spectroscopic data. absolute configuration geissolaevine (1) was deduced comparison experimental theoretically calculated ECD spectra. isolation workflow guided a molecular networking-based dereplication strategy using an in-house database...
This Data Descriptor announces the submission to public repositories of monoterpene indole alkaloid database (MIADB), a cumulative collection 172 tandem mass spectrometry (MS/MS) spectra from multiple research projects conducted in eight natural product chemistry laboratories since 1960s. All data have been annotated and organized promote reuse by community. Being unique these complex products, can be used guide dereplication targeting new related alkaloids within mixtures when applying...
Abstract Three new depsidones, parmosidones F – G (1 2), and 8′-O-methylsalazinic acid (3), 3 diphenylethers, parmetherines A C (4 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures unambiguously determined by extensive spectroscopic analyses comparison literature data. The polyphenolics assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1 in particular inhibited...
Dibenzopyrrocoline alkaloids, found in lauraceous and hernandiaceous plants, have been studied since the 1950s. The absolute configuration of these including cryptaustoline, has a topic debate due to conflicting studies. Having our laboratory some authentic samples dibenzopyrrocoline-type Cryptocarya we decided reinvestigate their using modern spectroscopic techniques along with TDDFT calculations. NMR reinvestigation sample cryptowolinol led us revise its relative ML-J-DP4 DP4+ analyses....
Two novel bisindole alkaloids, goniomedines A (1) and B (2), possessing an unprecedented quebrachamine–pleioarpamine-type skeleton, in which indole moieties are fused via a dihydropyran unit, were isolated from the stem bark of Gonioma malagasy. The structures elucidated by comprehensive analysis MS NMR spectroscopic data. Their absolute configurations deduced following comparison experimental theoretically calculated ECD spectra through biogenetic considerations. Goniomedine (2) exhibited...
Abstract Guided by biosynthetic considerations, the total synthesis of dictazole B is reported for first time. Experimental evidence an easy access to challenging cyclobutane alkaloids marine origin, which are often postulated be precursors more complex structures, provided.
The phytochemical investigation of the lichen Parmotrema sancti‐angelii afforded three racemic compounds, sanctis A–C, which feature an original dibenzo‐2,8‐dioxabicyclo[3.3.1]nonane scaffold. These compounds were structurally characterized by extensive NMR spectroscopy analyses, comparison between experimental and theoretical spectroscopic data, X‐ray crystallography. metabolites are similar to procyanidin A display a methyl group instead pendant aromatic ring at C‐9, so far unprecedented...
Six new sulfonic acid-containing flavonoids, acidoflavanone (1), acidoauronol (2), 5-O-methylacidoauronol (3), acidoaurone (4), acidoisoflavone (5), and acidoflavonol (6), were isolated from the EtOH extract of roots Phyllanthus acidus. Their structures unambiguously established by interpretation their HRESIMS 1D 2D NMR data, single-crystal X-ray diffraction analysis, comparison to literature data. These represent first examples flavanones, auronols, aurones, isoflavones.
Traditional natural products discovery workflows implying a combination of different targeting strategies, including structure- and/or bioactivity-based approaches, afford no information about new compound structures until late in the pipeline. By integrating MS/MS prediction module and collaborative library (bio)chemical transformations, we have developed platform, coined MetWork, that is capable anticipating structural identity metabolites starting from any identified compound. In our...