A5102866930- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Plant chemical constituents analysis
- Synthesis of Organic Compounds
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Synthesis and Biological Activity
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- RNA and protein synthesis mechanisms
- Natural Compound Pharmacology Studies
- DNA and Nucleic Acid Chemistry
- Essential Oils and Antimicrobial Activity
- Analytical Chemistry and Chromatography
- Carbohydrate Chemistry and Synthesis
- Phytochemistry and Bioactivity Studies
Sorbonne Paris Cité
2012-2025
Université Paris Cité
2016-2025
Cibles Thérapeutiques et conception de médicaments
2019-2025
Centre National de la Recherche Scientifique
2016-2025
Institut Jean Lamour
2025
Université de Lorraine
2025
Université de Bordeaux
2014-2024
Institut de Recherche en Gestion
2014-2022
LMU Klinikum
2022
Délégation Paris 5
2012-2021
Purpose This paper aims to study the dimensions and subdimensions of humanitarian supply chain resilience through case an non-governmental organization (NGO) logistics facing international COVID-19 pandemic. Design/methodology/approach The methodology this empirical research is based on a qualitative using semistructured interviews with key actors Médecins Sans Frontières Logistique (MSF Log), NGO during crisis in 2020 2021. Findings data analysis highlighted four main resilience:...
Seven 1,2-dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydro-6-demethoxyacronycine esters diesters were synthesized via osmic oxidation of acronycine or 6-demethoxyacronycine followed by acylation. The derivatives found to be inactive, whereas in contrast, all the more potent than itself when tested against L1210 cells vitro. Four selected (17, 19, 21, 22) evaluated vivo murine P388 leukemia colon 38 adenocarcinoma implanted mice. All compounds markedly active at doses 4−16-fold...
The dialdehydes oleacein (2) and oleocanthal (4) are closely related to oleuropein (1) ligstroside (3), the two latter compounds being abundant iridoids of Olea europaea. By exploiting isolated from plant leaf extract, an efficient procedure has been developed for a one-step semisynthesis under Krapcho decarbomethoxylation conditions. Highlighted is fact that 5-lipoxygenase direct target with inhibitory potential (IC50: 2 μM) more potent than (1). This enzyme catalyzes initial steps in...
The synthesis and the antiproliferative activity against human breast MCF-7, SkBr3 prostate LNCaP cancer cell lines of a series bis(indolyl)methane derivatives are reported. new compounds was first accomplished by reaction different indoles with trimethoxyacetophenone in presence catalytic amounts hydrochloric acid. A second procedure involving use oxalic acid dihydrate [(CO2H)2·2H2O] N-cetyl-N,N,N-trimethylammonium bromide water carried out led to better yields. Compound 5b significantly...
This Data Descriptor announces the submission to public repositories of monoterpene indole alkaloid database (MIADB), a cumulative collection 172 tandem mass spectrometry (MS/MS) spectra from multiple research projects conducted in eight natural product chemistry laboratories since 1960s. All data have been annotated and organized promote reuse by community. Being unique these complex products, can be used guide dereplication targeting new related alkaloids within mixtures when applying...
Photosynthetic light-harvesting antennae are pigment-binding proteins that perform one of the most fundamental tasks on Earth, capturing light and transferring energy enables life in our biosphere. Adaptation to different environments led evolution an astonishing diversity systems. At same time, several strategies have been developed optimize input into photosynthetic membranes response fluctuating conditions. The basic feature these prompt responses is dynamic nature antenna complexes,...
de niveau recherche, publiés ou non, émanant des établissements d'enseignement et recherche français étrangers, laboratoires publics privés.
Plant-based food supplements (FS) of doubtful traceability have now emerged as a new threat to human health. Food adulterated with pharmaceutical ingredients are considered “medicines in disguise” by regulatory authorities, which is sub-category falsified medicines. In the context illegal manufacture and trade, well absence an official phyto- and/or pharmacovigilance system, emergency departments poison control centers constitute early warning system for detecting ingested suspect FS....
Self‐potential (SP) and magnetic surveys have been performed on the basaltic La Fournaise volcano (Réunion Island, Indian Ocean) between 1989 1992. The 1992 SP mapping of inner caldera (Enclos Fouqué) reveals high relative positive anomalies. They are interpreted as related to a large hydrothermal system. A anomaly 2 V is centered terminal cone. horseshoe‐shaped intersects This outlines main arcuate fracture zone (MFZ), oriented north‐south cone extending northeast southeast away from...
Abslroct-A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfblly aromatized to the corresponding pyrimidines with various oxidizing reagents.0-Demethylation such provides a simple route pyrimidinone derivatives which are otherwise difficult obtain.Hantzsch 1,4-dihydropyridines nifedipine-type (DHPs, e.g 1) belong most studied class calcium antagonists used in clinical treatment hypertension, cardiac arrhythmias, or...
A series of new prodrugs daunorubicin and doxorubicin which are candidates for antibody-directed enzyme prodrug therapy (ADEPT) is reported. These compounds (25a,b,c 32a,b,c) have been designed to generate cytotoxic drugs after activation with beta-glucuronidase. As expected, recovery the active drug was observed enzymatic cleavage by Escherichia coli beta-glucuronidase as well a fusion protein has obtained from human humanized CEA-specific binding region. The six highly stable more than...
Androgens have profound effects on the physiology of sebaceous gland. Using hamster ear gland model, we performed a detailed kinetic study to clarify mechanism androgen action function. We demonstrated that growth glands observed after treatment was due both an increase in sebocyte proliferation and parallel induction terminal differentiation, as evidenced by synthesis specific lipids such cholesterol esters, triglycerides, squalene. Accordingly, effect mRNA expression several key enzymes...
Benzo¿băcronycine (6-methoxy-3,3,14-trimethyl-3, 14-dihydro-7H-benzo¿bpyrano¿3,2-hăcridin-7-one, 4), an acronycine analogue with additional aromatic ring linearly fused on the natural alkaloid basic skeleton, was synthesized in three steps, starting from 3-amino-2-naphthalenecarboxylic acid (5). Eight 1, 2-dihydroxy-1,2-dihydrobenzo¿băcronycine esters and diesters (17-24) were obtained by catalytic osmic oxidation, followed acylation. All these compounds significantly more cytotoxic than...