A5068770921- Bee Products Chemical Analysis
- Natural Compound Pharmacology Studies
- Phytochemicals and Antioxidant Activities
- Bone Tissue Engineering Materials
- Alkaloids: synthesis and pharmacology
- Berberine and alkaloids research
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Biological and pharmacological studies of plants
- Neuroscience and Neuropharmacology Research
- Insect Pest Control Strategies
- Nicotinic Acetylcholine Receptors Study
- Traditional and Medicinal Uses of Annonaceae
- Insect and Pesticide Research
- Chemical synthesis and alkaloids
- Bioactive natural compounds
- Orthopaedic implants and arthroplasty
- Ginkgo biloba and Cashew Applications
- biodegradable polymer synthesis and properties
- Radiopharmaceutical Chemistry and Applications
- Advanced Glycation End Products research
- Polysaccharides and Plant Cell Walls
- Orthopedic Infections and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Ion channel regulation and function
Université d'Angers
2014-2024
Inserm
2000-2005
Molécules d'Intérêt Biologique
2000-2005
Pharmac
2005
Laboratoire de Biophotonique et Pharmacologie
1994
Accumulation in tissues and serum of advanced glycation end-products (AGEs) plays an important role pathologies such as Alzheimer's disease or, the event complications diabetes, atherosclerosis or renal failure. Therefore, there is a potential therapeutic interest compounds able to lower intra extracellular levels AGEs. Among them, natural antioxidants (AO) with true anti-AGEs capabilities would represent good candidates for development. The purpose this study was evaluate AO propolis batch...
During this study, the in vitro antifungal and antibacterial activities of different extracts (aqueous organic) obtained from a French propolis batch were evaluated. Antifungal activity was evaluated by broth microdilution on three pathogenic strains: Candida albicans, C. glabrata , Aspergillus fumigatus . Antibacterial assayed using agar dilution method 36 Gram-negative Gram-positive strains including Staphylococcus aureus Organic showed significant against albicans (MIC 80 between 16 31 µ...
Whether chemists or biologists, researchers dealing with metabolomics require tools to decipher complex mixtures. As a part of and initially dedicated identifying bioactive natural products, dereplication aims at reducing the usual time-consuming process known compounds isolation. Mass spectrometry nuclear magnetic resonance are most commonly reported analytical during analysis. Though it has low sensitivity, 13C NMR many advantages for such study. Notably, is nonspecific allowing...
This Data Descriptor announces the submission to public repositories of monoterpene indole alkaloid database (MIADB), a cumulative collection 172 tandem mass spectrometry (MS/MS) spectra from multiple research projects conducted in eight natural product chemistry laboratories since 1960s. All data have been annotated and organized promote reuse by community. Being unique these complex products, can be used guide dereplication targeting new related alkaloids within mixtures when applying...
Summary This study aimed to compare the protective effect of two geographically distinct propolis against formation advanced glycation end products (AGEs). The polyphenol content extracts (EEPs) was analysed using HPLC‐DAD‐MS profiling and evaluated for their effects pentosidine‐like AGEs. Dicarbonyl trapping capacities major EEP compounds were determined a methylglyoxal scavenging in vitro assay. Both samples characterised with high levels pinobanksin derivatives exhibiting strong anti‐AGE...
Concentrated bud macerates (CBMs) are obtained from meristematic tissues such as buds and young shoots by maceration in a solvent composed of glycerin, water ethanol (1/1/1/, v/v). Their traditional utilization gemmotherapy has gained interest the past years, knowledge their chemical characterization can provide commercial arguments, particularly to secure quality control. Therefore, an optimized method for phytochemical analysis including glycerol removal preliminary solid phase extraction...
It is essential to prevent microbial infections after osteoarticular trauma or prosthesis implantation. As an alternative antibiotic parenteral administration, antibiotic-loaded biomaterials allow high concentrations be obtained in situ without systemic toxicity. Although the formulation of biphasic calcium-phosphate (BCP)-vancomycin granules by isostatic compression has recently been used produce drug-delivery devices, stability vancomycin needs proven. In this study, was associated with...
Two new xanthones, caledonixanthone M 1 and caloxanthone L 2, one acid, caledonic acid 6 were isolated from the hexane-soluble extract of stem bark Calophyllum caledonicum. In course this phytochemical study, seven other known compounds - calothwaitesixanthone, calozeyloxanthone, allanxanthone, isoapetalic 3, calolongic 4, apetalic 5 isocalolongic 7 isolated. Their antifungal activity against growth human pathogenic fungus Aspergillus fumigatus was then investigated. The results indicated...
Abstract Introduction Xanthones are metabolites with a variety of biological properties. The Clusiaceae family, which until recently included the genus Calophyllum , is recognised for its production monohydroxylated and polyhydroxylated xanthones. Presently, C. brasiliense only spp. known to occur in Yucatan peninsula. Objective To use combination traditional phytochemical methods carbon‐13 nuclear magnetic resonance ( 13 C‐NMR) dereplication analysis identify xanthones stem bark . Material...
ABSTRACT Treatment of methicillin-resistant Staphylococcus aureus osteomyelitis requires a prolonged antibiotic therapy with vancomycin. Because its weak diffusion, the in situ implantation vancomycin could be interesting. The activity encapsulated microparticles was evaluated vitro and vivo on rabbit showed good compared to intravenous administration.
Abstract This data descriptor reports on the upload to a public repository (GNPS) of IQAMDB, IsoQuinoline and Annonaceous Metabolites Data Base, comprising 320 tandem mass spectra. project originated from our in-house collection isoquinolines. The diversity compounds included in this database was further extended through contribution two additional laboratories involved isoquinoline alkaloids research: University Angers Manaus. generated MS/MS were processed annotated an individual basis...
Propolis is a resinous natural substance collected by honeybees from buds and exudates of various trees plants; it widely accepted that the composition propolis depends on phytogeographic characteristics site collection.The aim this study was to determine phytochemical ethanolic extracts eight batches in different regions Benin (north, center, south) Congo, Africa.Characterization samples performed using hyphenated chromatographic methods combined with carbon-13 nuclear magnetic resonance...
Endothelial cells (ECs) are key players in inflammation and immune responses involved numerous pathologies. Although attempts were experimentally undertaken to prevent control EC activation, drug leads probes still remain necessary. Natural products (NPs) from Clusiaceous Calophyllaceous plants previously reported as potential candidates endothelial dysfunction. The present study aimed identify more precisely the molecular scaffolds that could limit activation. Here, 13 polyphenols belonging...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkaloidal Content of Four Berberis Species. Structure Berberilaurine, a New BisbenzyltetrahydroisoquinolineJean-Frédéric Weber and Alain FournetCite this: J. Nat. Prod. 1989, 52, 1, 81–84Publication Date (Print):January 1989Publication History Published online1 July 2004Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/np50061a010https://doi.org/10.1021/np50061a010research-articleACS PublicationsRequest reuse permissionsArticle...
Discovering new solutions for crop protection is a major challenge the next decades as result of ecotoxicological impact classical fungicides, emergence fungicide resistances, and consequence climate change on pathogen distribution. Previous work fungal mutants deficient in unfolded protein response (UPR) supported that targeting this pathway promising plant disease control strategy. In particular, we showed UPR involved virulence by altering cell against host defense compounds, such...
The purpose of this study was to develop an in vitro perfusion technique or "continuous-flow adhesion cell" model predict the vivo performances different mucoadhesive drug delivery systems based on hydrogels. Two studies were performed, either using a rabbit small intestine polyethylene surface; four gels--two poly(acrylic acid)s (PAAs) (carbomer [CM] and polycarbophil [PC]), ethyleneoxide-propyleneoxide block copolymer (Poloxamer 407 [PM]), polysaccharide (scleroglucane [SG])--were...