A5073151775- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural Compound Pharmacology Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Natural product bioactivities and synthesis
- Retinoids in leukemia and cellular processes
- Free Radicals and Antioxidants
- Bioactive Compounds and Antitumor Agents
- Phytochemicals and Antioxidant Activities
- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Vitamin C and Antioxidants Research
- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- Alkaloids: synthesis and pharmacology
- Toxin Mechanisms and Immunotoxins
- Biochemical Acid Research Studies
- Anesthesia and Sedative Agents
- Natural Antidiabetic Agents Studies
- Edible Oils Quality and Analysis
- Synthesis and bioactivity of alkaloids
- Bee Products Chemical Analysis
OmegaChem (Canada)
2023-2024
Université d'Angers
2020-2023
Ho Chi Minh City University of Science
2022
Vietnam National University Ho Chi Minh City
2022
Université Bretagne Loire
2018
Institut de Cancérologie de l'Ouest
2016
Abstract Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. Here we show, by library screening of potential human metabolites, that long-chain ω-carboxylates are potent allosteric inhibitors 5-lipoxygenase, a key enzyme in the biosynthesis chemoattractant and vasoactive leukotrienes. 13-((2 R )-6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)-2,6,10-trimethyltridecanoic acid (α-T-13′-COOH) can be synthesized from α-tocopherol...
We are reporting a short and convenient pathway for the synthesis of novel β‐carboline‐bisindole hybrid compounds from relatively cheap commercially available chemicals such as tryptamine, dialdehydes indoles. These newly designed can also be prepared in high yields with tolerance many functional groups under mild conditions. Notably, these exhibited some promising applications anticancer agents against three common cancer cell lines MCF‐7 (breast cancer), SK‐LU‐1 (lung HepG2 (liver cancer)....
Abstract This research aims to create innovative compounds that incorporate 1,2,4‐triazole and exhibit α‐glucosidase inhibitory potential. Similar our previously reported series of N ‐aryl 2‐{[5‐(naphthalen‐1‐ylmethyl)‐4‐phenyl‐4 H ‐1,2,4‐triazol‐3‐yl]thio}acetamide compounds, we explore here 4‐ethyl instead 4‐phenyl as substituent. The synthesis process effectively yielded these with the highest yield reaching up 91 % for compound ‐phenyl‐2‐{[5‐(naphthalen‐1‐ylmethyl)‐4‐ethyl‐4 5 a . Their...
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations resolvin E3, a specialized proresolving lipid mediator. SAR studies on semisynthesized analogues highlight α-amplexichromanol (
Modulation of major histocompatibility complex (MHC) expression using drugs has been proposed to control immunity. Phytochemical investigations on Garcinia species have allowed the isolation bioactive compounds such as polycyclic polyprenylated acylphloroglucinols (PPAPs). PPAPs guttiferone J (1), display anti-inflammatory and immunoregulatory activities while garcinol (4) is a histone acetyltransferases (HAT) p300 inhibitor. This study reports isolation, identification biological...
Discovering new solutions for crop protection is a major challenge the next decades as result of ecotoxicological impact classical fungicides, emergence fungicide resistances, and consequence climate change on pathogen distribution. Previous work fungal mutants deficient in unfolded protein response (UPR) supported that targeting this pathway promising plant disease control strategy. In particular, we showed UPR involved virulence by altering cell against host defense compounds, such...
Abstract Intrathecal analgesia has increased over the past two decades based on high level proof of efficacy in patients with cancer. Morphine and Ziconotide remains reference. Polyanalgesic Consensus Conference IT treatment algorithm recommends as second line therapy opioids/ziconotide combination. Sufentanil ziconotide combination can be used. The implantable pumps development helped to improve comfort patient. refills were prepared under a laminar airflow hood strictly aseptic conditions,...
Nine compounds including a new one, garcichaudiic acid (1), were isolated from the bark of G. gaudichaudii and their structures characterized mainly by 1 D 2 NMR experiments. The antioxidant capacity was determined using DPPH radical scavenging assay anti-hyperglycemic activity assessed measuring inhibitory effect against α-glucosidase. Among them, compound 4 showed higher than positive control, ascorbic acid, while both 7 exhibited more significant α-glucosidase reference drug acarbose....
Inflammation is a complex process driven by innate immune cells that produce pro-inflammatory lipid mediators during acute phase and specialized pro-resolving (SPM) in the resolution phase. Macrophages of M2 subtype play major role inflammation as they strongly express ALOX15 ALOX15B effectively release SPM, including resolvins, protectins maresins. This mediator class switch terminates inflammatory processes restores tissue homeostasis. Current anti-inflammatory therapy largely targets...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”