A5002556287- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
- Natural Products and Biological Research
- Allergic Rhinitis and Sensitization
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Pain Mechanisms and Treatments
- Sulfur Compounds in Biology
- Immune cells in cancer
- Antioxidant Activity and Oxidative Stress
- Helminth infection and control
- Sphingolipid Metabolism and Signaling
- Dermatology and Skin Diseases
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Estrogen and related hormone effects
- Sirtuins and Resveratrol in Medicine
- Parasites and Host Interactions
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- Antifungal resistance and susceptibility
Friedrich Schiller University Jena
2016-2024
Helmholtz Zentrum München
2020-2021
Technical University of Munich
2020-2021
Jena University Hospital
2017
Abstract Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. Here we show, by library screening of potential human metabolites, that long-chain ω-carboxylates are potent allosteric inhibitors 5-lipoxygenase, a key enzyme in the biosynthesis chemoattractant and vasoactive leukotrienes. 13-((2 R )-6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)-2,6,10-trimethyltridecanoic acid (α-T-13′-COOH) can be synthesized from α-tocopherol...
Abstract Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic but mechanisms are diffuse. Here, we show that 1,2-dioleoyl- sn -glycero-3-phospho-(1’-myo-inositol) [PI(18:1/18:1)] is a SCD1-derived signaling lipid, which inhibits p38 mitogen-activated kinase activation, counteracts...
Proinflammatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided 5-LO-activating protein (FLAP). LT biosynthesis inhibitors currently under clinical investigation as treatments for respiratory and cardiovascular diseases. Here, we have revealed a sex bias in the efficiency of clinically relevant inhibitors, showing that their effects superior females. We found androgens cause these differences impeding LT-biosynthetic 5-LO/FLAP complex assembly. Lower doses FLAP inhibitor MK886...
Abstract The severity and course of inflammatory processes differ between women men, but the biochemical mechanisms underlying these sex differences are elusive. Prostaglandins (PG) leukotrienes (LT) lipid mediators linked to inflammation. We demonstrated superior LT biosynthesis in human neutrophils monocytes, mouse macrophages from females, we confirmed vivo where female mice produced more LTs during zymosan-induced peritonitis versus males. Here, report PG production acute In late phase...
Abstract Alternative (M2)-polarized macrophages possess high capacities to produce specialized proresolving mediators (SPM; i.e., resolvins, protectins, and maresins) that play key roles in resolution of inflammation tissue regeneration. Vacuolar (H+)-ATPase (V-ATPase) is fundamental inflammatory cytokine trafficking secretion was implicated macrophage polarization toward the M2 phenotype, but its role SPM production lipid mediator biosynthesis general elusive. In this study, we show...
Aging is accompanied by chronic, low-grade systemic inflammation, termed inflammaging, a main driver of age-associated diseases. Such sterile inflammation typically characterized elevated levels pro-inflammatory mediators, such as cytokines, chemokines and reactive oxygen species causing organ damage. Lipid mediators play important roles in the fine-tuning both promotion resolution inflammation. Yet, it remains unclear how lipid fit within concept inflammaging their biosynthesis function...
Introduction: Sex differences in inflammation are obvious and contribute to divergences the incidence severity of inflammation-related diseases that frequently preponderate women. Lipid mediators (LMs), mainly produced by lipoxygenase (LOX) cyclooxygenase (COX) pathways from polyunsaturated fatty acids (PUFAs), regulate all stages inflammation. Experimental clinical studies revealed sex for selected LM without covering entire spectrum, only few have addressed respective role hormones. Here,...
Abstract Unresolved inflammation, due to unfavorable imbalances between pro‐inflammatory and pro‐resolving mediators, leads chronic inflammatory pathologies that are often sex‐biased regulated by sex hormones, including bowel disease. Lipid mediators (LM) produced from polyunsaturated fatty acids various lipoxygenases (LOX) cyclooxygenases govern all stages of i.e., the initiation progression eicosanoids its resolution specialized (SPM). Here, we reveal sex‐specific differences in murine...
<h3>Background</h3> Epidemiological studies and clinical investigations indicate a beneficial impact of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) on the inflammatory activity rheumatoid arthritis (RA). However, knowledge about physiological effects individual compounds eicosapentaenoic acid (EPA) docosahexaenoic (DHA) is limited. <h3>Objectives</h3> In our pilot study presented here, we investigated benefit daily intake foods enriched with microalgae oil as source DHA in RA...