A5088448994- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Bone Metabolism and Diseases
- Bone health and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone and Joint Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Inflammatory Myopathies and Dermatomyositis
- Musculoskeletal synovial abnormalities and treatments
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Urticaria and Related Conditions
- Autoimmune and Inflammatory Disorders
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Orthopedic Surgery and Rehabilitation
- Dupuytren's Contracture and Treatments
- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- IgG4-Related and Inflammatory Diseases
Jena University Hospital
2016-2025
Friedrich Schiller University Jena
2015-2024
Klinikum Magdeburg
2014-2022
Center for Clinical Studies
2014-2020
Universitätsmedizin Greifswald
2018
Klinik für Schlafmedizin
2017
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2009
Schiller International University
2000-2008
Center for Rheumatology
2001
Interstitial lung disease (ILD) is a severe pulmonary complication in inflammatory rheumatic diseases (IRD) and associated with significantly increased morbidity mortality. That why ILD screening at very early stage, the onset of IRD, essential. The objective present study was to evaluate diagnostic value utility stepwise approach as potential tool patients newly diagnosed IRD.
Objective. Regarding interactions between pro-inflammatory cytokines and bone metabolism in rheumatoid arthritis (RA), we investigated the relationship serum levels of interleukin (IL)-1β, IL-6, soluble interleukin-2 receptor (sIL-2r), C-reactive protein (CRP), vitamin D metabolites 25-hydroxyvitamin D3 (25OHD3 ) 1,25-dihydroxyvitamin [1,25(OH)2D3 ], intact parathyroid hormone (iPTH) as well urinary parameters turnover 74 post-menopausal women with RA. Results. SIL-2r correlated negatively...
There have only been few studies examining rheumatoid arthritis (RA)-related skin manifestations in larger patient populations. Herein, we present current data on the prevalence and spectrum of cutaneous lesions RA, addressing disease activity scores, anti-CCP antibodies as well novel pharmacological approaches.Between November 2006 July 2007, 214 patients with RA treated at Division Rheumatology, University Hospital Jena, Germany, were prospectively examined.27.5 % exhibited RA-related...
The aim of this study was to assess a novel approach for the quantification finger joint space narrowing and destruction in patients with rheumatoid arthritis (RA) focusing on peripheral hand articulations. A total 280 verified RA underwent computerized semi-automated measurements distance at articulations based radiographs. Z-Score, which can differentiate between alterations caused by versus age/gender-related changes, calculated as comparative parameter. severity also quantified Sharp...
Systemic sclerosis (SSc) is a systemic, autoimmune connective tissue disease characterized by vasculopathy and microvascular changes. Fluorescence Optical Imaging (FOI) technique used to assess inflammation in patients with arthritis; this study FOI quantify the h and. Endothelial Microparticle (EMP) can reflect damage or activation of endothelium but also actively modulate processes inflammation, coagulation vascular function. The aim present was EMP FOI, determine an association between...
Background Giant cell arteritis (GCA) with the involvement of extracranial vessels is increasingly coming into focus. Isolated aortic in acute phase GCA probably more frequent than estimated because only a minority patients show typical symptoms. 18 F-fluorodeoxyglucose positron emission tomography/CT (PET/CT) reliable imaging tool to diagnose GCA. The aim this retrospective study was quantify arterial at onset newly diagnosed by PET/CT and evaluate influence glucocorticoid (GC) treatment on...
Abstract Objectives Inflammatory rheumatic diseases (IRD) are often associated with interstitial lung disease (ILD). The aim of the present study was to establish a correlation between findings on HRCT and immunological bronchoalveolar lavage (BAL). Methods included 74 patients newly diagnosed IRD evidence ILD following pattern: ground-glass opacities (GGO), non-specific pneumonia (NSIP) usual (UIP). Patients other pattern were excluded. No patient received any immunosuppressive therapy. In...
Rheumatoid arthritis (RA) is associated with an increased risk for osteoporosis and osteoporotic fractures. Since the treatment of RA has improved significantly in recent years, we can expect RA-associated to decrease good disease control. Therefore, conducted a retrospective study investigate whether frequency fractures changed during 24 years RA.
Objective . The aim of this study was to visualize soft tissue inflammation using FOI on patients with Systemic Sclerosis (SSc) characterized by SSc-related Raynaud’s phenomenon and detect the therapeutic response treatment iloprost or alprostadil. Methods Twenty-one SSc twenty-six healthy controls were prospectively included. intravenously treated alprostadil over seven days. performed at baseline after days an intravenous application indocyanine green (ICG). hands divided into nineteen...