A5058592243- Marine Ecology and Invasive Species
- Planarian Biology and Electrostimulation
- Plant and Biological Electrophysiology Studies
- Congenital heart defects research
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Telomeres, Telomerase, and Senescence
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Studies on Chitinases and Chitosanases
- Orthopedic Infections and Treatments
- Mitochondrial Function and Pathology
- Orthopaedic implants and arthroplasty
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Antimicrobial Peptides and Activities
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- bioluminescence and chemiluminescence research
- Sirtuins and Resveratrol in Medicine
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
German Centre for Cardiovascular Research
2022-2025
Universitätsmedizin Göttingen
2022-2025
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2017-2022
Spanish National Centre for Cardiovascular Research
2015-2016
Instituto de Salud Carlos III
2015
Abstract Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic but mechanisms are diffuse. Here, we show that 1,2-dioleoyl- sn -glycero-3-phospho-(1’-myo-inositol) [PI(18:1/18:1)] is a SCD1-derived signaling lipid, which inhibits p38 mitogen-activated kinase activation, counteracts...
Bednarek et al. find that telomerase, well known for its role in elongating telomere ends, is essential during zebrafish heart regeneration.Cardiac injury hyperactivates telomerase and increases length cardiac cells.In telomerase-null mutants, cells accumulate DNA damage do not efficiently proliferate response to injury.
The molecular mechanisms that drive mammalian cardiomyocytes out of the cell cycle soon after birth remain largely unknown. Here, we identify telomere dysfunction as a critical physiological signal for cardiomyocyte cell-cycle arrest. We show telomerase activity and length decrease sharply in wild-type mouse hearts birth, resulting with dysfunctional telomeres anaphase bridges positive arrest protein p21. further premature pushes cycle. Cardiomyocytes from telomerase-deficient mice (G3...
Underlying mechanisms of how infectious inflammation is resolved by the host are incompletely understood. One hallmark resolution activation specialized pro-resolving mediators (SPMs) that enhance bacterial clearance and promote tissue repair. Here, we reveal α-hemolysin (Hla) from Staphylococcus aureus as a potent elicitor SPM biosynthesis in human M2-like macrophages mouse peritoneum through selective 15-lipoxygenase-1 (15-LOX-1). S. aureus-induced formation M2 abolished upon Hla depletion...
Die kontraktile Funktion von Skelettmuskeln ist eng mit der subzellulären Struktur verbunden. Kombination Kraftmessungen auf Gewebeebene und Mikroskopie subzellulärer Ebene würde daher wichtigen Aufschluss geben, wie unter welchen Bedingungen die durch vorgegeben beeinflusst wird. Bestehende in vitro Gewebemodelle sind zwar vielseitig einsetzbar, aber nicht dynamischer hochauflösender kompatibel. Wir haben eine neue Plattform entwickelt, hochauflösende 3D-Mikroskopie funktionalen...
As a major component of intracellular trafficking, the coat protein complex II (COPII) is indispensable for cellular function during embryonic development and throughout life. The four SEC24 proteins (A-D) are essential COPII components involved in cargo selection packaging. A human disorder corresponding to alterations currently only known SEC24D. Here, we report that biallelic loss SEC24C leads syndrome characterized by primary microcephaly, brain anomalies, epilepsy, hearing loss, liver...
Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset hypertrophic cardiomyopathy. In this study, we investigate the mechanistic consequences of a homozygous variant LZTR1L580P by using patient-specific CRISPR-Cas9-corrected induced pluripotent stem cell (iPSC) cardiomyocytes. Molecular, cellular, functional phenotyping combination with silico prediction identify an LZTR1L580P-specific disease mechanism provoking cardiac...
Abstract Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset hypertrophic cardiomyopathy. However, the underling disease mechanisms of missense driving cardiac pathology poorly understood. Hence, therapeutic options for limited. In this study, we investigated mechanistic consequences a novel homozygous variant L580P by using patient-specific CRISPR/Cas9-corrected iPSC-cardiomyocytes. Molecular, cellular, functional...
Planarians are able to stand long periods of starvation by maintaining adult stem cell pools and regenerative capacity.The molecular pathways that needed for the maintenance regeneration during not known.Here, we show down-regulation chaperonin TRiC/CCT subunits abrogates capacity planarians starvation, but TRiC/ CCT dispensable in fed planarians.Under they required maintain mitotic fidelity blastema formation.We TRiC modulate unfolded protein response (UPR) ATP levels starved...
Summary Fasting protects stem cells and increases cell functionality through mechanisms which are not fully understood. Planarians only able to regenerate their bodies, but also stand long periods of starvation by shrinking in size. This adaptation is possible because a large population adult indefinitely self-renew even under starved conditions thus confer planarians with immortality. How maintain healthy fuel proliferation allowing regeneration unknown. Here we found the TCP-1 ring complex...