A5030689032- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Appendicitis Diagnosis and Management
- Anorectal Disease Treatments and Outcomes
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Enhanced Recovery After Surgery
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Trauma and Injuries
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Liver Disease and Transplantation
- Abdominal vascular conditions and treatments
- Abdominal Surgery and Complications
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
Magna Graecia University
2015-2025
Hôpitaux Universitaires Henri-Mondor
2013-2025
Centre Hospitalier de Beauvais
2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2024
Collaborative Group (United States)
2023
Start Treatment & Recovery Centers
2023
Université Paris-Est Créteil
1999-2021
Assistance Publique – Hôpitaux de Paris
2008-2021
Paris-Est Sup
2014-2021
Early detection of Colon Cancer using Molecular Markers and Microbiota
2019-2021
Several bacterial species have been implicated in the development of colorectal carcinoma (CRC), but CRC-associated changes fecal microbiota and their potential for cancer screening remain to be explored. Here, we used metagenomic sequencing samples identify taxonomic markers that distinguished CRC patients from tumor-free controls a study population 156 participants. Accuracy detection was similar standard occult blood test (FOBT) when both approaches were combined, sensitivity improved >...
Abstract Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms morbidity, mortality, and long-term quality life. BDIs have an estimated incidence 0.4–1.5%, but considering number cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most are recognized either during procedure or immediate period. However, some may discovered later period,...
DNA methylation is a well-known epigenetic mechanism involved in gene regulation. Several genes were reported hypermethylated CRC, althought no marker was proven to be individually of sufficient sensitivity or specificity routine clinical practice. Here, we identified novel markers and assessed their combined use for diagnostic accuracy. We used arrays on samples from several effluents characterize profiles CRC controls, as established by colonoscopy pathology findings, selected two...
Robotic surgery was introduced to overcome laparoscopic drawbacks. This study aimed compare the learning curve of robotic-assisted right colectomy (RRC) versus laparoscopic-assisted (LRC) for colon cancer with respect operative times and perioperative outcomes. In addition, health-related costs associated both procedures were analyzed compared.Between 2012 2015, 30 consecutive patients underwent RRC 50 LRC cancer. All performed by a surgical fellow novice in minimally invasive colorectal...
BackgroundInsulin resistance in visceral adipose tissue (VAT), skeletal muscle and liver is a prominent feature of most patients with obesity. How this association arises remains poorly understood. The objective study was to demonstrate that the decrease insulin receptor (INSR) expression signaling VAT from obese individuals an early molecular manifestation might play crucial role cascade events leading systemic resistance.MethodsTo clarify INSR dysfunction obesity, we first measured samples...
To prepare for surgery, surgeons often recur to surgical videos, with YouTube being reported as the preferred source. This study aimed compare evaluation of three trainees and senior 25 most viewed laparoscopic appendectomy videos listed on YouTube. Additionally, we assessed video conformity published guidelines how report surgery (LAP-VEGaS).Based number visualization, uploaded between 2010 2018 were selected. Videos evaluated technical performance (GOALS score), critical view safety (CVS),...
The high-mobility group AT-hook 1 (HMGA1) protein is a nuclear architectural factor that can organize chromatin structures. It regulates gene expression by controlling the formation of stereospecific multiprotein complexes called "enhanceosomes" on AT-rich regions target promoters. Previously, we reported defects in HMGA1 caused decreased insulin receptor and increased susceptibility to type 2 diabetes mellitus humans mice. Interestingly, mice with disrupted had significantly smaller islets...
To report the technique and results of an alternative method vascular clamping during liver resections.Most resections require to avoid excessive blood loss. Portal triad is often sufficient, but it does not suppress backflow bleeding, which can be prevented only by hepatic exclusion. The latter adds inferior vena cava, in hypotension, requiring invasive anesthetic management. There growing evidence that intermittent better tolerated than continuous clamping, especially presence underlying...
Background: Liraglutide is the first glucagon-like peptide-1 receptor agonist (GLP-1 RA) based on human GLP-1 sequence, with potential weight loss benefits, approved for treatment of type 2 diabetes (T2D) mellitus. Herein, we aimed to assess 5-year effectiveness in management and glycometabolic control a Southern Italian cohort overweight/obese T2D patients, who were naïve RAs. Patients Methods: Forty overweight or obese patients treated at doses up 1.8 mg/day, combination one more oral...
Abstract Background The primary objective was to evaluate the rates of older patients with colorectal cancer (CRC) who were eligible for a clinical trial, invited participate, and, ultimately, included. secondary assess reasons ineligibility, noninvitation, and noninclusion factors associated. Materials Methods Sujets AGés dans les Essais Cliniques (SAGE; Older Subjects in Clinical Trials) multicenter prospective cohort established seven centers (10 departments medical oncology, digestive...
Background . SGLT-2 (sodium-glucose cotransporter-2) inhibitors are a novel class of oral hypoglycemic agents for the management type 2 diabetes mellitus (T2DM). Herein, we aimed to assess long-term effectiveness and safety in Southern Italy population subjects affected by T2DM. Patients Methods 408 diabetic patients treated with one three currently available (dapagliflozin, empagliflozin, canagliflozin), either alone or combination other antidiabetic drugs, were retrospectively assessed at...