A5049400527- Asthma and respiratory diseases
- Sphingolipid Metabolism and Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Inflammatory mediators and NSAID effects
- Adenosine and Purinergic Signaling
- Neonatal Respiratory Health Research
- Sulfur Compounds in Biology
- MicroRNA in disease regulation
- Mast cells and histamine
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Agricultural pest management studies
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Pharmacological Effects and Assays
- Biomarkers in Disease Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Botanical Research and Chemistry
- Extracellular vesicles in disease
- Phytochemistry and Bioactive Compounds
- Mycobacterium research and diagnosis
- Cancer, Stress, Anesthesia, and Immune Response
University of Naples Federico II
2018-2024
Federico II University Hospital
2022-2024
Astragalus membranaceus (Fisch.) Bunge root is used as herbal medicine for its immunomodulating activities in Chinese medicine. Recently, beneficial properties of A. on allergic diseases have been proposed. Here we investigated the role a commercial extract membranaceus, standardized to 16% polysaccharides, regulating immune-inflammatory response vitro and vivo therapeutic application asthma. inhibited prostaglandin E2 leukotriene C4 production stimulated J774 peritoneal macrophages,...
Airway remodelling is a critical feature of chronic lung diseases. Epithelial-mesenchymal transition (EMT) represents an important source myofibroblasts, contributing to airway remodelling. Here, we investigated the sphingosine-1-phosphate (S1P) role in EMT and its involvement asthma-related dysfunction.
The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery anti-inflammatory drugs. Here, we describe identification an indoline-based compound inhibiting both 5-lipoxygenase (5-LOX) soluble epoxide hydrolase (sEH). In silico analysis in-house library identified nine compounds as potential 5-LOX inhibitors. Enzymatic cellular assays revealed indoline derivative 43 notable inhibitor, guiding new analogues. These...
Bronchial asthma is an inflammatory airway disease with ever-increasing incidence. Therefore, innovative management strategies are urgently needed. MicroRNAs small molecules that play a key role in lungs cellular functions and involved chronic diseases, such as bronchial asthma. This study aims to compare microRNA serum expression between subjects asthma, obesity, the most common co-morbidity healthy controls obtain specific profile specifically related lung inflammation.We collected samples...
// Chiara Colarusso 1 , Michela Terlizzi Anne-Sophie Lamort 2 Ida Cerqua 4 Fiorentina Roviezzo Georgios Stathopoulos 3 Aldo Pinto and Rosalinda Sorrentino Department of Pharmacy (DIFARMA), University Salerno, Italy Molecular Lung Carcinogenesis Group, Comprehensive Pneumology Center Institute for Biology Disease, Ludwig-Maximilians Helmholtz Center, Munich, Germany Laboratory Respiratory Carcinogenesis, Physiology, Faculty Medicine, Patras, Greece Pharmacy, Naples, Correspondence to:...
Acute pancreatitis (AP) is a potentially life-threatening illness characterized by an exacerbated inflammatory response with limited options for pharmacological treatment. Here, we describe the rational development of library soluble epoxide hydrolase (sEH) inhibitors treatment AP. Synthesized compounds were screened in vitro their sEH inhibitory potency and selectivity, results rationalized means molecular modeling studies. The most potent studied pharmacokinetic profile, where compound 28...
Chronic obstructive pulmonary disease (COPD) is a progressive lung that commonly considered to be potent driver of non-small cell cancer (NSCLC) development and related mortality. A growing body evidence supports the role immune system, mainly played by alveolar macrophages (AMs), as key axes regulating COPD or NSCLC phenotypes in response harmful agents. MicroRNAs (miRNAs) are small non-coding RNAs influence most biological processes interfere with several regulatory pathways. The purpose...
Chronic obstructive pulmonary disease (COPD) is a progressive lung that commonly considered to be potent driver of non-small cell cancer (NSCLC) development and related mortality. A growing body evidence supports role the immune system, mainly played by alveolar macrophages (AMs), in key axes regulating COPD or NSCLC phenotypes response harmful agents. MicroRNAs (miRNAs) are small non-coding RNAs influence most biological processes interfere with several regulatory pathways. The purpose this...
Introduction: Hydrogen sulfide (H 2 S) is emerging as an important potential therapeutic option for respiratory inflammatory diseases. In this study, we investigated the effectiveness of a novel corticosteroid derivative, that chemically linked to H S donor, in managing asthma features. Methods: The effects prednisone (PS), donor (4-hydroxybenzamide; TBZ), and their combination (PS-TBZ) have been evaluated vitro vivo . experiments were conducted using lipopolysaccharidestimulated J774...
Background and Purpose A critical role for sphingosine kinase/sphingosine‐1‐phosphate (S1P) pathway in the control of airway function has been demonstrated respiratory diseases. Here, we address S1P contribution a mouse model mild chronic obstructive pulmonary disease (COPD). Experimental Approach C57BL/6J mice have exposed to room air or cigarette smoke up 11 months killed at different time points. Functional molecular studies performed. Key Results Cigarette caused emphysematous changes...
Background/Aims: Sphingosine-1-phosphate (S1P) is a membrane-derived bioactive phospholipid involved in many lung physiological and pathological processes. Higher levels of S1P have been registered broad range respiratory diseases, including inflammatory disorders cancer. The aim our study was to understand the role healthy versus tumor cells after Toll-Like Receptors (TLRs) activation, well-known modulators sphingolipid metabolism. Methods: Lung adenocarcinoma non-pathological human...
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations resolvin E3, a specialized proresolving lipid mediator. SAR studies on semisynthesized analogues highlight α-amplexichromanol (
Background. Air pollution is becoming a threatening issue for human health. Many epidemiological studies relate air index to adverse effects in terms of disease incidence and/or exacerbation. In our previous studies, we found pollutants can induce the release pro-inflammatory cytokines from peripheral blood cells. To better understand, on lung, took advantage an animal model. Experimental Approach. Mice were intratracheally and daily exposed urban collected particulate matter (PM, PM10 PM1)...
The airways are a target tissue of type I allergies and atopy is the main etiological factor bronchial asthma. A predisposition to allergy individual response allergens dependent upon environmental host factors. Early studies performed clarify role extracellular adenosine in highlighted importance adenosine-generating enzymes CD73, together with CD39, as an innate protection system against lung injury. In experimental animals, deletion CD73 has been associated immune autoimmune diseases. Our...
Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate acquired immunity cell functions. We previously demonstrated CD73 required assessment of a controlled allergic sensitization, in mice. Here, we evaluated response to aerosolized allergen female-sensitized mice lacking comparison their wild type counterpart. Results obtained show, CD73,...
Abstract Lipidomics-guided screening of unexplored chemical space in natural products provides access to small molecules capable modifying cellular lipid profiles on a global scale. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp . shapes profile immune cells, favoring anti-inflammatory and pro-resolving over pro-inflammatory mediators. Structural variation revealed derivatives inhibit leukotriene biosynthesis varying extents while differentially upregulating...
Asthma is a major noncommunicable disease, affecting both children and adults, represents one of the causes leading to high health care costs due need for chronic pharmacological treatments. The standard gold therapy inflammation in asthmatic patients involves use glucocorticoids even if their often related serious adverse effects. Growing evidence suggests biological relevance hydrogen sulfide (H2S) pathogenesis airway diseases. Hence, aiming associate beneficial effects steroidal...
Asthma is a major noncommunicable disease, affecting both children and adults, represents one of the causes leading to high health care costs due need for chronic pharmacological treatments. The standard gold therapy inflammation in asthmatic patients involves use glucocorticoids even if their often related serious adverse effects. Growing evidence suggests biological relevance hydrogen sulfide (H