A5027878780- Sphingolipid Metabolism and Signaling
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Fibroblast Growth Factor Research
- Atherosclerosis and Cardiovascular Diseases
- Cancer therapeutics and mechanisms
- Respiratory viral infections research
- Cardiac Structural Anomalies and Repair
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Plant biochemistry and biosynthesis
- Cardiovascular Issues in Pregnancy
- Immune cells in cancer
- Cardiovascular Disease and Adiposity
- Asthma and respiratory diseases
- Microtubule and mitosis dynamics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- ATP Synthase and ATPases Research
- COVID-19 diagnosis using AI
- Beetle Biology and Toxicology Studies
- Cardiac Health and Mental Health
University of Naples Federico II
2020-2025
University of Salerno
2021-2023
Institute for Experimental Endocrinology and Oncology
2020
National Research Council
2020
Autologous platelet concentrates (APC) are widely used in the infiltrative treatment of knee osteoarthritis (OA) to enhance tissue healing and relieve pain. Aim this study was identify predictive biomarkers for clinical outcomes patients with grade I OA. A panel growth factors (GFs) cytokines determined peripheral blood (PB) APC. The Numeric Pain Rating Scale (NPRS) as a readout before after APC infiltration. lower white cell (WBC) count higher Monocyte-chemoattractant Protein-1 levels PB...
Interleukin-1beta (IL-1β) is crucially involved in the pathogenesis of coronary atherosclerotic diseases (CAD) and its inhibition has proven cardiovascular benefits. Epicardial adipose tissue (EAT) a local source inflammatory mediators which may negatively affect surrounding arteries. In present study, we explored relationship between serum EAT levels IL-1β IL-1 receptor antagonist (IL-1ra) patients with chronic syndrome (CCS) recent acute (ACS).We obtained biopsies 54 CCS (Group 1) 33 ACS...
Background/Aims: The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) exerts a multitude of effects on respiratory cell physiology and pathology through five S1P receptors (S1PR1-5). Epidemiological studies proved high levels circulating in non-small lung cancer (NSCLC) patients. Studies literature suggest that support carcinogenesis but the exact mechanism is still elusive. aim this study was to understand mechanism/s underlying S1P-mediated tumor proliferation. Methods: We used...
Artemetin is a valuable 5-hydroxy-3,6,7,3′,4′-pentamethoxyflavone present in many different medicinal plants with very good oral bioavailability and drug-likeness values, owing to numerous bioactivities, such as anti-inflammatory anti-cancer ones. Here, multi-disciplinary plan has been settled applied for identifying the artemetin target(s) inspect its mechanism of action, based on drug affinity-responsive target stability targeted limited proteolysis. Both approaches point disclosure...
Background/Aims: Sphingosine-1-phosphate (S1P) is a membrane-derived bioactive phospholipid involved in many lung physiological and pathological processes. Higher levels of S1P have been registered broad range respiratory diseases, including inflammatory disorders cancer. The aim our study was to understand the role healthy versus tumor cells after Toll-Like Receptors (TLRs) activation, well-known modulators sphingolipid metabolism. Methods: Lung adenocarcinoma non-pathological human...
In the last few years, several efforts have been made to identify original strategies against glioblastoma multiforme (GBM): this requires a more detailed investigation of molecular mechanism GBM so that novel targets can be identified for new possible therapeutic agents. Here, using combined biochemical and proteomic approach, we evaluated ability blood-brain barrier-permeable 2,3-benzodiazepin-4-one, called 1g, interfere with activity expression brain glycogen phosphorylase (PYGB) on U87MG...
Tatridin A (TatA) is a germacrane sesquiterpenoid containing one E-double bond and Z-double in its 10-membered ring, which fused to 3-methylene-dihydrofuran-2-one moiety. bioactivity has been poorly investigated despite interesting chemical structure. Here, functional proteomic platform was adapted disclose most reliable targets leukemia monocytic cells, phosphoglycerate kinases were recognized as the affine enzymes. Through combination of limited proteolysis molecular docking, it discovered...
Sex is a biological variable that can reflect clinical outcomes in terms of quality life, therapy effectiveness, responsiveness and/or toxicity. Sphingosine-1-phosphate (S1P) lipidic mediator whose activity be influenced by sex. To evaluate whether the S1P axis underlies sex ‘instructions’ lung during physiological and oncological conditions, sphingosine were quantified blood healthy (H) volunteers, adenocarcinoma (ADK) squamous cell carcinoma (SCC) patients both sexes. receptors their...
Population Medicine considers the following types of articles:• Research Papers -reports data from original research or secondary dataset analyses.• Review -comprehensive, authoritative, reviews within journal's scope.These include both systematic and narrative reviews.• Short Reports -brief reports research.• Policy Case Studies articles on policy development at a regional national level.• Study Protocols -articles describing protocol study.• Methodology -papers that present different...