A5033718593- Neuroscience and Neuropharmacology Research
- GABA and Rice Research
- Cannabis and Cannabinoid Research
- Epilepsy research and treatment
- Diet and metabolism studies
- Liver Disease and Transplantation
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Medicinal Plants and Neuroprotection
- Coffee research and impacts
- Biochemical effects in animals
- Estrogen and related hormone effects
- Ion channel regulation and function
- COVID-19 Clinical Research Studies
- Diet, Metabolism, and Disease
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Free Radicals and Antioxidants
- Lung Cancer Diagnosis and Treatment
- Additive Manufacturing and 3D Printing Technologies
- Pancreatic function and diabetes
- Glycogen Storage Diseases and Myoclonus
- Venous Thromboembolism Diagnosis and Management
- Natural Products and Biological Research
University of Modena and Reggio Emilia
2014-2025
Istituto Nazionale Biostrutture e Biosistemi
2022-2024
Institute of Biostructure and Bioimaging
2021
University of Florence
2013
University of Padua
2004
University of Pavia
2004
Georgetown University
1997-2001
University of Virginia
1998
University of Milan
1998
Amsterdam UMC Location University of Amsterdam
1998
Abstract Immunoblot analysis, using antibodies against distinct N ‐methyl‐ d ‐aspartic acid (NMDA) receptor subunits, illustrated that the NR2A and NR2B subunit proteins have developmental profiles in cultured cortical neurons similar to those seen vivo . NR1 subunits display high levels of expression within first week. In contrast, is barely detectable at 7 days vitro (DIV) then gradually increased mature DIV21. Immunocytochemical analysis indicated NMDA cluster dendrites soma neurons....
The present study was aimed at revealing the metabolic changes that occurred in cellular lipid pattern of acute and chronic myeloid leukaemia cells following treatment with cannabidiol (CBD). CBD is a non-psychoactive compound Cannabis sativa L., which has shown an antiproliferative action these type cancer cells. reduced cell viability initiated apoptotic necrotic processes both lines time dose-dependent manner, showing (HL-60) greater sensitivity than ones (K-562), without differences...
Glioblastoma multiforme (grade IV glioma) is characterized by a high invasive potential making surgical intervention extremely challenging and patient survival very limited. Current pharmacological approaches show at best slight improvements in the therapy against this type of tumour. Microtubules are often target antitumoral drugs, specific drugs affecting their dynamics acting on microtubule associated proteins (MAPs) without producing depolymerization could affect both glioma cell...
Glioblastoma multiforme (grade IV glioma) is characterized by a high invasive potential, making surgical intervention extremely challenging and patient survival very limited. Current pharmacological approaches show, at best, slight improvements in the therapy against this type of tumor. Microtubules are often target antitumoral drugs, specific drugs affecting their dynamics acting on microtubule-associated proteins (MAPs) without producing depolymerization could affect both glioma cell...
Many reports have shown promising beneficial effects of long-chain polyunsaturated fatty acids (L-PUFAs) the omega 3 series in several brain diseases. In present study, we tested hypothesis that supplement reduced pro-inflammatory functions vitro and vivo. We demonstrated a rich PUFAs (SRP) increased cell viability dose-dependent manner suggesting its protective role against lipopolysaccharide (LPS)-induced death BV2 microglial line. same cultures, reactive oxygen species (ROS) nitric oxide...
Tetracycline antibiotics (TCs) have been widely employed to treat bacterial infections and other pathologic conditions in humans pets. Although most of TCs almost ruled out from the human clinical practice they are still used as growth promoters promiscuity overcrowding pathologies intensive animal farming. As a consequence, commonly found all ecological compartments with potential direct or indirect toxicological effects on animals and, generally, living organisms. Moreover, vitro...
On March 11, 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19) a pandemic; from that date, vaccine race has begun, and many technology platforms to develop specific effective COVID-19 have been launched in several clinical trials (protein subunit, RNA-based, DNA-based, replicating viral vector, nonreplicating inactivated virus, live attenuated virus-like particle). Among next-generation strategies, nucleoside-modified messenger RNA vaccines appear most...
Background/Aim —Despite some controversy, it has been suggested that endogenous benzodiazepine plays a role in the pathogenesis of hepatic encephalopathy. The aim present study was to evaluate concentrations benzodiazepines and peptide, diazepam binding inhibitor, blood patients with liver cirrhosis without overt encephalopathy, compare these levels those consumers commercial benzodiazepines. Subjects —Normal subjects (90), (14), cirrhotic (113) were studied. Methods —Endogenous measured by...
In the last decades, adverse food reactions have increased considerably in dogs and cats. this study we report on possible onset of intolerances symptoms, including otitis, diarrhoea, generalised anxiety, dermatitis a cohort 8 consuming commercial diets. All received an organic chicken-based diet for 15 days. We performed analysis blood biochemical parameters, kibble composition, oxytetracycline (OTC) serum concentration before after days supplementation. hypothesised that chronic intake...
In recent years the possibility of observing by microscopy dynamic activity living cells has been largely pursued. We have developed a low-cost (~ 260 euros) on-stage cell incubator for inverted optical microscopes. This device allows to keep in good conditions their survival and proliferation. The is based on use Arduino microprocessor interfaced with LabView. It can be connected computer via USB port allowing monitor register all useful parameters measurements: temperature, CO2...
Background: Fibre-type Cannabis sativa L. (hemp) usually contains cannabidiolic acid and cannabidiol as the main non-psychoactive cannabinoids. Even though there is evidence of neuroprotective activity pure cannabidiol, no in vitro studies have reported so far role hemp extracts on neuroprotection. The objective this study was to evaluate effect cellular models neurotoxicity. Methods: One extract obtained from raw inflorescences, while other prepared same plant material submitted a...
Abstract In this study, extracts from non‐psychoactive Cannabis sativa L. varieties were characterized by means of ultra high‐performance liquid chromatography coupled with high‐resolution mass spectrometry (UHPLC‐HRMS) and their antiproliferative activity was assessed in vitro. The human chronic myelogenous leukaemia cell line K562 chosen to investigate the mechanism death. effect on cycle death analysed flow cytometry. Proteins related apoptosis studied western blotting. Mechanical...
We have shown that the vertebrate neuropeptide N-acetylaspartylglutamate (NAAG) meets criteria for a neurotransmitter, including function as selective metabotropic glutamate receptor (mGluR) 3 agonist. Short-term treatment of cerebellar granule cells with NAAG (30 microM) results in transient increase content GABA(A) alpha6 subunit mRNA. Using quantitative PCR, this was determined to be up 170% control values. Similar effects are seen following trans-1-aminocyclopentane-1,3-dicarboxylate and...
Metal-based nanoparticles (NPs), are currently used in many application fields including consumer products, pharmaceuticals, and biomedical treatments. In spite to their wide applications, an in-depth study of potential toxic effects is still lacking. The aim the present research was investigate initiator or promoter-like activity different metallic NPs such as gold, iron, cobalt, cerium using Balb/3T3 two-stage transformation assay. results indicated that all selected NPs, except for when...