A5014028187- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Planarian Biology and Electrostimulation
- Cellular Mechanics and Interactions
- Renal and related cancers
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Reproductive System and Pregnancy
- Proteoglycans and glycosaminoglycans research
- Extracellular vesicles in disease
- Plant and Biological Electrophysiology Studies
- Reproductive tract infections research
- Cardiovascular Function and Risk Factors
- Pluripotent Stem Cells Research
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Molecular Communication and Nanonetworks
- Neurological Disorders and Treatments
- Biofield Effects and Biophysics
- Cardiac Fibrosis and Remodeling
- Biliary and Gastrointestinal Fistulas
- Cardiac Ischemia and Reperfusion
- Renal cell carcinoma treatment
- Gut microbiota and health
El.En. Group (Italy)
2024
Istituto Nazionale Biostrutture e Biosistemi
2007-2022
Creative Research Enterprises (United States)
2019-2021
Jackson and Tull (United States)
2021
University of Bologna
2007-2019
IBSA Institut Biochimique (Switzerland)
2019
Lomonosov Moscow State University
2019
Bologna Research Area
2017-2018
Institute of Biostructure and Bioimaging
2018
International Flame Research Foundation
2018
Abstract Background Term Amniotic membrane (AM) is a very attractive source of Mesenchymal Stem Cells (MSCs) due to the fact that this fetal tissue usually discarded without ethical conflicts, leading high efficiency in MSC recovery with no intrusive procedures. Here we confirmed term AM, as previously reported literature, an abundant hMSCs; particular further investigated AM differentiation potential by assessing whether these cells may also be committed angiogenic fate. In agreement...
We have developed a mixed ester of hyaluronan with butyric and retinoic acid (HBR) that acted as novel cardiogenic/vasculogenic agent in human mesenchymal stem cells isolated from bone marrow, dental pulp, fetal membranes term placenta (FMhMSCs). HBR remarkably enhanced vascular endothelial growth factor (VEGF), KDR, hepatocyte (HGF) gene expression the secretion angiogenic, mitogenic, antiapoptotic factors VEGF HGF, priming cell differentiation into cells. also increased transcription...
Somatic cells can be directly reprogrammed to alternative differentiated fates without first becoming stem/progenitor cells. Nevertheless, the initial need for viral-mediated gene delivery renders this strategy unsafe in humans. Here, we provide evidence that exposure of human skin fibroblasts a Radio Electric Asymmetric Conveyer (REAC), an innovative device delivering radio electric conveyed fields at radiofrequency 2.4 GHz, afforded remarkable commitment toward cardiac, neuronal, and...
Possible cardiac repair by adult stem cell transplantation is currently hampered poor viability and delivery efficiency, uncertain differentiating fate in vivo, the needs of ex vivo expansion, consequent delay after onset heart attack. By aid magnetic resonance imaging, positron emission tomography, immunohistochemistry, we show that injection a hyaluronan mixed ester butyric retinoic acid (HBR) into infarcted rat hearts afforded substantial cardiovascular recovery myocardial performance....
AimsPre-treating placenta-derived human mesenchymal stem cells (FMhMSCs) with a hyaluronan mixed ester of butyric and retinoic acid (HBR) potentiates their reparative capacity in rodent hearts. Our aim was to test FMhMSCs large-animal model by employing novel combination vivo ex analyses.
Glioblastoma multiforme (grade IV glioma) is characterized by a high invasive potential making surgical intervention extremely challenging and patient survival very limited. Current pharmacological approaches show at best slight improvements in the therapy against this type of tumour. Microtubules are often target antitumoral drugs, specific drugs affecting their dynamics acting on microtubule associated proteins (MAPs) without producing depolymerization could affect both glioma cell...
Glioblastoma multiforme (grade IV glioma) is characterized by a high invasive potential, making surgical intervention extremely challenging and patient survival very limited. Current pharmacological approaches show, at best, slight improvements in the therapy against this type of tumor. Microtubules are often target antitumoral drugs, specific drugs affecting their dynamics acting on microtubule-associated proteins (MAPs) without producing depolymerization could affect both glioma cell...
Background Development of molecules chemically modifying the expression crucial orchestrator(s) stem cell commitment may have significant biomedical impact. We recently developed hyaluronan mixed esters butyric and retinoic acids (HBR), turning cardiovascular fate into a high-yield process. The HBR mechanism(s) remain still largely undefined. Methodology/Principal Findings show that in both mouse embryonic (ES) cells human mesenchymal from fetal membranes term placenta (FMhMSCs),...
<h3>BACKGROUND AND PURPOSE:</h3> Aqueductal CSF stroke volume (ACSV) measured by phase-contrast MR imaging is a tool for selection of surgical patients with idiopathic normal-pressure hydrocephalus (iNPH). The aim the present study was to investigate whether there relationship between clinical outcome and changes in ACSV iNPH who have been shunted. <h3>MATERIALS METHODS:</h3> Sixty-five shunted underwent evaluation measurements 7–30 days before 1, 3, 6, 12 months after surgery....
Acute kidney injury (AKI) is a major health care condition with limited current treatment options. Within this context, stem cells may provide clinical approach for AKI. Moreover, synthetic compound previously developed, hyaluronan monoesters butyric acid (HB), able to induce metanephric differentiation, formation of capillary-like structures, and secretion angiogenic cytokines, was tested in vitro. Thereafter, we investigated the effects human mesenchymal from fetal membranes (FMhMSCs),...
Among perinatal stem cells of the umbilical cord, human Wharton's jelly mesenchymal (hWJ-MSCs) are great interest for cell-based therapy approaches in regenerative medicine, showing some advantages over other MSCs. In fact, hWJ-MSCs, placed between embryonic and adult MSCs, not tumorigenic harvested with few ethical concerns. Furthermore, these can be easily cultured vitro, maintaining both properties a high proliferative rate several passages, as well trilineage capacity differentiation....
Abstract Barley (1–3)β-D-Glucan (BBG) enhances angiogenesis. Since pasta is very effective in providing a BBG-enriched diet, we hypothesized that the intake of containing 3% BBG (P-BBG) induces neovascularization-mediated cardioprotection. Healthy adult male C57BL/6 mice fed P-BBG (n = 15) or wheat (Control, n for five-weeks showed normal glucose tolerance and cardiac function. With food similar to Control, 109% survival rate (P < 0.01 vs. Control) after ischemia (30 min)/reperfusion (60...
An increasing number of studies suggest that chlamydiae can infect immune cells. The altered cell function could contribute to the progression several chronic inflammatory diseases. aim this study was comparatively evaluate Chlamydia pneumoniae (CP) and trachomatis (CT) interactions with in vitro infected human blood monocytes. Fresh isolated monocytes were viable CP CT elementary bodies infectivity evaluated by recultivating disrupted permissive epithelial production reactive oxygen...
Cytoskeletal proteins provide architectural and signaling cues within cells. They are able to reorganize themselves in response mechanical forces, converting the stimuli received into specific cellular responses. Thus, cytoskeleton influences cell shape, proliferation, even differentiation. In particular, affects fate of mesenchymal stem cells (MSCs), which highly attractive candidates for therapy approaches due their capacity self-renewal multi-lineage Cytochalasin B (CB), a cyto-permeable...
Human mesenchymal stem cells (hMSCs) are an effective tool in regenerative medicine notably for their intrinsic plentiful paracrine activity rather than differentiating properties. The hMSC secretome includes a wide spectrum of regulatory and trophic factors, encompassing several naked molecules as well different kinds extracellular vesicles (EVs). Among EVs, exosomes represent intriguing population, able to shuttle proteins, transcription genetic materials, with relevant role cell-to-cell...
Oscillatory patterns permeate the universe and are essential requisite in living cells. Circadian clocks exist at subcellular single-cell level. Chromatin is assembled into rhythmic oscillatory domains driving stem cell growth/differentiation up to higher hierarchical embryo development. The cytoskeleton organized as rhythmically oscillating networks, producing radioelectric fields that may turn local events non-local, long-ranging paths. For decades, scientists have used chemical tools...