Beatrice Bighi

ORCID: 0000-0002-7469-2455
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About
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Research Areas
  • Covalent Organic Framework Applications
  • Layered Double Hydroxides Synthesis and Applications
  • Metal-Organic Frameworks: Synthesis and Applications
  • Cellular Mechanics and Interactions
  • Zeolite Catalysis and Synthesis
  • Molecular Biology Techniques and Applications
  • Cancer Cells and Metastasis
  • Lipid Membrane Structure and Behavior
  • 3D Printing in Biomedical Research
  • Chemical Synthesis and Characterization
  • Synthesis and pharmacology of benzodiazepine derivatives
  • RNA Research and Splicing
  • Electrochemical Analysis and Applications
  • Force Microscopy Techniques and Applications
  • Neuroscience and Neural Engineering
  • Sulfur Compounds in Biology
  • Synthesis of Tetrazole Derivatives
  • Ammonia Synthesis and Nitrogen Reduction
  • Clay minerals and soil interactions
  • Mesoporous Materials and Catalysis
  • Electrochemical sensors and biosensors
  • Mosquito-borne diseases and control
  • Photosynthetic Processes and Mechanisms
  • Extraction and Separation Processes
  • Neuroscience and Neuropharmacology Research

University of Modena and Reggio Emilia
2019-2025

Istituto Nanoscienze
2024-2025

Harvard University
2021

Aberrant splicing events are associated with colorectal cancer (CRC) and provide new opportunities for tumor diagnosis treatment. The expression of the splice variants NF-YA, DNA binding subunit transcription factor NF–Y, is deregulated in multiple types compared to healthy tissues. NF–YAs NF–YAl isoforms differ transactivation domain, which may result distinct transcriptional programs. In this study, we demonstrated that transcript higher aggressive mesenchymal CRCs predicts shorter...

10.1016/j.canlet.2023.216262 article EN cc-by-nc-nd Cancer Letters 2023-06-10

Glioblastoma multiforme (grade IV glioma) is characterized by a high invasive potential making surgical intervention extremely challenging and patient survival very limited. Current pharmacological approaches show at best slight improvements in the therapy against this type of tumour. Microtubules are often target antitumoral drugs, specific drugs affecting their dynamics acting on microtubule associated proteins (MAPs) without producing depolymerization could affect both glioma cell...

10.20944/preprints202501.1700.v1 preprint EN 2025-01-23

Glioblastoma multiforme (grade IV glioma) is characterized by a high invasive potential, making surgical intervention extremely challenging and patient survival very limited. Current pharmacological approaches show, at best, slight improvements in the therapy against this type of tumor. Microtubules are often target antitumoral drugs, specific drugs affecting their dynamics acting on microtubule-associated proteins (MAPs) without producing depolymerization could affect both glioma cell...

10.3390/ijms26062767 article EN International Journal of Molecular Sciences 2025-03-19

HIV-1 envelope glycoprotein (Env) is a transmembrane protein that mediates membrane fusion and viral entry. The membrane-interacting regions of the Env, including membrane-proximal external region (MPER), domain (TMD), cytoplasmic tail (CT), not only are essential for Env incorporation but also can strongly influence antigenicity Env. Previous studies have incrementally revealed structures MPER, TMD, KS-LLP2 CT. Here, we determined NMR structure full-length CT using fragment comprising TMD...

10.1021/jacs.1c01762 article EN Journal of the American Chemical Society 2021-04-22

Abstract Cadmium(II) acetate in tablet form, immersed ethanol solutions with a high concentration of heptanethiol (30–80 mM), was able to develop self‐assembled sail‐shaped structures. The solution which the structure is formed totally organic (both solute and solvent), thus representing unique case among Chemical Gardens. constituting material for this new Garden (CG) made single phase, namely cadmium heptanethiolate microcrystalline consisting central cluster [Cd n S ]. morphological...

10.1002/syst.202000048 article EN ChemSystemsChem 2020-12-02

Abstract The electrode‐immobilized Met80Ala variant of yeast iso‐1 cytochrome c in mixed water/dimethylsulfoxide (DMSO) solutions up to 60 % v/v DMSO shows thermodynamic and kinetic parameters electron exchange electrocatalytic properties towards O 2 reduction fully comparable those water. This is the result moderate protein conformational changes thanks immobilization that, a certain extent, preserves structure, possibly due constraints on mobility/flexibility induced by electrostatic...

10.1002/celc.202100499 article EN ChemElectroChem 2021-05-18

Abstract Chemical garden (CG) from copper(II) sulfate, nitrate and chloride (CG CuSO 4 , CG Cu(NO 3 ) 2 CuCl were grown, characterized the structural compositional point of view by using scanning electron microscopy, X‐ray powder diffraction, elemental analysis, thermogravimetric analysis coupled with mass spectrometry, DR (diffuse reflectance) UV‐Vis‐NIR spectroscopy. The main crystalline phases, controlled anion starting salt, brochantite kobyashevite for gerhardtite, rouaite anthonyite...

10.1002/syst.202100034 article EN ChemSystemsChem 2021-09-24

Kaolinite functionalized by the μ-oxo Fe3+-phenanthroline complex (Fe+3Phen) was selected to test its ability efficiently remove and store gaseous heptanethiol (HPT). Spectroscopic techniques, elemental analysis, thermal analysis coupled with evolved gas mass spectrometry were employed characterize material before after exposure define adsorption process. The amount of HPT trapped kaolinite 60 days is 0.10940 moles per 100 g which, considering adsorbed Fe+3Phen (0.00114 kaolinite), means a...

10.1021/acsomega.1c04145 article EN cc-by-nc-nd ACS Omega 2021-11-23
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