A5010784832- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Nitric Oxide and Endothelin Effects
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Bone and Dental Protein Studies
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Connexins and lens biology
- Apelin-related biomedical research
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
National Research Council
2013-2024
Istituto di Fisiologia Clinica
2015-2024
University of Pisa
1998-2024
Scuola Superiore Sant'Anna
2011-2023
Fondazione Toscana Gabriele Monasterio
2008-2016
Azienda Ospedaliera Universitaria Pisana
2016
Leiden University Medical Center
2016
Vall d'Hebron Hospital Universitari
2016
Turku University Hospital
2016
University of Turku
2016
The objectives of this paper are to develop and test the ability a wearable physiological sensors system, based on ECG, EDA, EEG, capture human stress assess whether detected changes in signals correlate with salivary cortisol level, which is reliable, objective biomarker stress.15 healthy participants, eight males seven females, mean age 40.8 ± 9.5 years, wore set three commercial record during Maastricht Acute Stress Test, an experimental protocol known elicit robust physical mental...
Abstract Background: Cardiac natriuretic hormones (CNHs) are a family of related peptides, including atrial peptide (ANP), brain (BNP), and other peptides derived from the N-terminal portion proANP proBNP chains. Assays for cardiac have been proposed to help assess clinical conditions associated with expanded fluid volume. In particular, assays can be useful distinguishing healthy subjects patients in different stages heart failure. Measurements these also considered prognostic indicators...
Sister chromatid exchange (SCE) and micronuclei (MN) analysis was carried out on 1,650 healthy individuals living in Pisa two nearby small cities, Cascina Navacchio (Ca-Na). The effect of smoking SCEs linearly correlated with the number cigarettes per day, an increase 7.3% detectable for as few 1–10/day. Ex-smokers showed intermediate mean values (8.09 ± 1.88) comparison never smokers (7.54 1.61) current (8.45 1.94). Mean ex-smokers decreased time cessation, reaching within 8 years. extent...
In order to study the relationships between sex hormones, aging, and circulating levels of cardiac natriuretic peptides define reference values for atrial peptide (ANP) brain (BNP) assays, we measured plasma in a large group healthy adults divided according age sex. We studied 216 subjects both sexes (109 men 107 women) with ranging from 20 77 years (mean 43.2+/-14.8 years). All were non-obese had normal arterial blood pressure; they free acute diseases, including asymptomatic heart disease....
The mechanisms that mediate the cardioprotective action of steroid hormones in postmenopausal women are poorly understood. To study inter-relationship between female and cardiac natriuretic peptides, plasma levels atrial peptide (ANP) brain (BNP) were measured women, both before after oestrogen replacement therapy. A total 22 healthy (mean age 51.9±4.6 years) enrolled study; all had been for at least 1 year reported climacteric symptoms accompanied by increased follicle-stimulating hormone...
Objective— Circulating levels of high-sensitivity cardiac troponin T (hs-cTnT) and N terminal pro brain natriuretic peptide (NT-proBNP) are predictors prognosis in patients with coronary artery disease (CAD). We aimed at evaluating the effect atherosclerosis myocardial ischemia on release hs-cTnT NT-proBNP suspected CAD. Approach Results— Hs-cTnT were measured 378 (60.1±0.5 years, 229 males) stable angina unknown CAD enrolled Evaluation Integrated Cardiac Imaging (EVINCI) study. All...
Obesity is a complex pathology with interacting and confounding causes due to the environment, hormonal signaling patterns, genetic predisposition. At present, Zucker rat an eligible model for research on obesity metabolic syndrome, allowing scrutiny of gene expression profiles. Real-time PCR benchmark method measuring mRNA expressions, but accuracy reproducibility its data greatly depend appropriate normalization strategies. In model, no specific reference genes have been identified in...
The metabolic modulator trimetazidine (TMZ) has been suggested to induce a shift from myocardial fatty acid oxidation (FAO) glucose utilization, but this mechanism remains unproven in humans. of plasma derived FA is commonly measured humans, whereas the contribution triglycerides stored myocardium poorly characterized.To verify hypothesis that TMZ induces shift, we combined positron emission tomography (PET) and magnetic resonance spectroscopy ((1)H-MRS) measure FAO intracellular lipids,...
Abstract Expression of endothelin (ET)-1 is increased in endothelial cells exposed to angiotensin II (Ang II), leading dysfunction and cardiovascular disorders. Since von Willebrand Factor (vWF) blockade improves function coronary patients, we hypothesized that targeting vWF with short interference RNA (siRNA) prevents Ang II-induced ET-1 upregulation. Nearly 65 ± 2% silencing porcine aortic (PAOECs) was achieved vWF-specific siRNA without affecting cell viability growth. While showing...