A5025960539- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Drug Transport and Resistance Mechanisms
- Glutathione Transferases and Polymorphisms
- DNA and Nucleic Acid Chemistry
- Acute Lymphoblastic Leukemia research
- Toxic Organic Pollutants Impact
- Biochemical Analysis and Sensing Techniques
- Pesticide Exposure and Toxicity
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Plant Genetic and Mutation Studies
- RNA and protein synthesis mechanisms
- Genetically Modified Organisms Research
- Air Quality and Health Impacts
- Multiple Myeloma Research and Treatments
- Folate and B Vitamins Research
- Olfactory and Sensory Function Studies
- Environmental Toxicology and Ecotoxicology
- Effects of Radiation Exposure
- Fungal and yeast genetics research
- Pesticide and Herbicide Environmental Studies
- Radiation Effects and Dosimetry
- Cancer therapeutics and mechanisms
University of Pisa
2011-2021
University of Trento
2013
Ospedale Cisanello
2003
Universidad Cardenal Herrera CEU
2002
Istituto Nazionale per le Ricerche Cardiovascolari
1995
University of Ferrara
1988-1994
University of Pavia
1990
Instituto di Biofisica
1982-1985
Fred Hutch Cancer Center
1981
Justus-Liebig-Universität Gießen
1976
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker chromosomal damage and genome stability human populations. Much theoretical evidence has been accumulated supporting the causal role MN induction cancer development, although prospective cohort studies are needed to validate risk biomarker. A total 6718 subjects from 10 countries, screened 20 laboratories for between 1980 2002 ad hoc or routine cytogenetic surveillance, were selected...
Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a standard method for monitoring chromosome damage human populations. The first results of an analysis pooled data from laboratories using the cytokinesis-block micronucleus (CBMN) assay and participating HUMN (HUman MicroNucleus project) international collaborative study are presented. effects laboratory protocol, scoring criteria, host factors on baseline micronucleated binucleate cell (MNC) frequency...
The pharmacokinetics and pharmacodynamics of morphine are under the control several polymorphic genes, which can account for part observed interindividual variation in pain relief. We focused on two such genes: ABCB1/MDR1, a major determinant bioavailability, OPRM1, encodes μ-opioid receptor, primary site action morphine. One hundred forty-five patients Italian origin undergoing therapy were genotyped single-nucleotide polymorphism (SNP) C3435T ABCB1/MDR1 A80G SNP OPRM1. Pain relief...
Cigarette smoke is a mixture of chemicals having direct and/or indirect toxic effects on different lung cells. We investigated the effect cigarette human fibroblasts (HFL-1) oxidation and apoptosis. Cells were exposed to various concentrations (1, 5, 10%) extract (CSE) for 3 h, oxidative stress apoptosis assessed by fluorescence-activated cell sorting confocal laser fluorescence microscopy. Both exhibited dose-response relationship with CSE concentrations. Lung also showed marked DNA...
Tomato fruit has assumed the status of ‘functional food’ due to association between its consumption and a reduced likelihood certain types cancers CVD. The nutraceutical value tomatoes can be affected by cultivation conditions, e.g. phytochemical content fruits may increase with establishment beneficial mycorrhizal symbioses in plants. A multidisciplinary study was carried out gain knowledge on antioxidant, oestrogenic/anti-oestrogenic genotoxic activity tomato produced present results...
Molecular sensing in the lingual mucosa and gastro-intestinal tract play a role detection of ingested harmful drugs toxins. Therefore, genetic polymorphisms affecting capability initiating these responses may be critical for subsequent efficiency avoiding and/or eliminating possible threats to organism. By using tagging approach region Taste Receptor 2R38 (TAS2R38) gene, we investigated all common variation this gene relation colorectal cancer risk with case-control study German population...
Abstract The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population studies of TAS2Rs suggest demographic events have played critical role in evolution these genes. We here utilized largest database yet analyzed,...
<b><i><i>Background</i>: </i></b> Postmortem studies suggest excessive free radical toxicity in the substantia nigra of patients with PD. Increased lipid peroxidation and oxidative DNA damage have been reported CNS. Markers stress identified blood <b><i><i>Objective</i>: To assess presence spontaneous chromosome primary or peripheral leukocytes untreated <b><i><i>Methods</i>: Patients de novo PD (20) control subjects (16), matched for age, sex, smoking habits, underwent cytogenetic analysis...
Sister chromatid exchange (SCE) and micronuclei (MN) analysis was carried out on 1,650 healthy individuals living in Pisa two nearby small cities, Cascina Navacchio (Ca-Na). The effect of smoking SCEs linearly correlated with the number cigarettes per day, an increase 7.3% detectable for as few 1–10/day. Ex-smokers showed intermediate mean values (8.09 ± 1.88) comparison never smokers (7.54 1.61) current (8.45 1.94). Mean ex-smokers decreased time cessation, reaching within 8 years. extent...
Recent evidence indicates that small, nonprotein-coding RNA molecules, called microRNAs (miRNAs), control cell growth, differentiation, and apoptosis, are also involved in tumorigenesis. miRNAs can bind to the 3′ untranslated regions (3′UTRs) of messenger RNAs interfere with their translation. We hypothesized common polymorphisms within genes or targets could have an important impact for individual's risk develop complex diseases. In this study, we selected 3′UTRs 129 pathways commonly...
The RET protooncogene is constitutively activated by point mutations in hereditary medullary thyroid carcinomas (MTCs). somatic have also been reported 40–50% of sporadic MTCs. Several single nucleotide polymorphisms the gene described general population as well patients with MTC. These allelic variants do not seem to confer any transforming activity tyrosine kinase domain gene. Because exon 11 polymorphism determines an important aminoacidic variation (G691S), we studied its frequency 212...