A5049556952- Cancer-related Molecular Pathways
- Neuroblastoma Research and Treatments
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Synthesis and biological activity
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Click Chemistry and Applications
- Ocular Oncology and Treatments
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Cancer therapeutics and mechanisms
- RNA Research and Splicing
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Chromatin Remodeling and Cancer
- Synthesis and Characterization of Heterocyclic Compounds
- Multiple Myeloma Research and Treatments
University of Sassari
2016-2025
Temple University
2016-2025
Université Paris Cité
2016
Philadelphia University
2012-2014
Temple College
2004-2014
Institute of Biomedical Science
2012
University of Siena
2004-2011
Sbarro Health Research Organization
2010-2011
University of Palermo
2011
Thomas Jefferson University
1998-2002
Cathelicidins are a family of myeloid antimicrobial peptide precursors that have been identified in several mammalian species (Zanetti, M., Gennaro, R., and Romeo, D. (1995) FEBS Lett. 374, 1-5). Two novel bovine congeners deduced from cDNA. Their C-terminal sequences 27 28 residues correspond to putative peptides with cationic N-terminal region predicted assume an amphipathic α-helical conformation followed by hydrophobic tail. Peptides corresponding these chemically synthesized shown exert...
Several myeloid antimicrobial peptide precursors have been shown to consist of a N‐terminal proregion similar protein named cathelin and structurally varied C‐terminal domain. Proteins with these features cathelicidins. In this paper we report the cDNA sequences three ovine cathelicidins 155, 160 190 residues, respectively, cationic corresponding putative domains. These are include Cys‐rich sequence 12 which is bovine cyclic dodecapeptide, novel 29 residue SMAP‐29 possible α‐helical...
The Cdk2 kinase has long been known to be involved in the progression of mammalian cells past G1 phase restriction point and through DNA replication cell cycle. Rb family proteins, consisting pRb, p107, pRb2/p130, also shown monitor phase, mostly their interaction with E2F members. p107 is able inhibit activity this via a p21-related domain present C terminus protein. We show here that pRb2/p130 possesses activity, but separate domain. Moreover, we correlate increased expression during...
Rhabdomyosarcoma (RMS) is a pediatric tumor that arises from muscle precursor cells. RMS cells express several markers of early myogenic differentiation, but they fail to complete both differentiation program and cell cycle arrest, resulting in uncontrolled proliferation incomplete myogenesis. Previous studies showed EZH2, which involved cancer progression, overexpressed RMS, functional binding between its expression role formation or progression has not yet been demonstrated. We...
Background Development of molecules chemically modifying the expression crucial orchestrator(s) stem cell commitment may have significant biomedical impact. We recently developed hyaluronan mixed esters butyric and retinoic acids (HBR), turning cardiovascular fate into a high-yield process. The HBR mechanism(s) remain still largely undefined. Methodology/Principal Findings show that in both mouse embryonic (ES) cells human mesenchymal from fetal membranes term placenta (FMhMSCs),...
A series of novel 1,3,4-oxadiazoles was synthesized and evaluated for their cytotoxic activity in vitro tumor models. Four the new compounds (2d, 2j, 2k, 2n) showed growth inhibition XTT dye assay. The most active agent, high potency against human cancer cells with IC50s ranging from 0.05 to 1.7 μM. Preliminary SAR correlations suggested that nature chains on oxadiazole is important antitumor vitro. Compound 2j determined a G2/M arrest cell cycle also activated strong apoptotic response....
Polycomb group proteins represent a global silencing system involved in development regulation. In specific, they regulate the transition from proliferation to differentiation, contributing stem-cell maintenance and inhibiting an inappropriate activation of differentiation programs. Enhancer Zeste Homolog 2 (EZH2) is catalytic subunit repressive complex 2, which induces transcriptional inhibition through tri-methylation histone H3, epigenetic change associated with gene silencing. EZH2...
Small cell lung cancer (SCLC) is an aggressive type of with high mortality that caused by frequent relapses and acquired resistance. Despite several target-based approaches potential therapeutic impact on SCLC have been identified, numerous targeted drugs not successful in providing improvements patients when used as single agents. A combination therapies could be a strategy to induce maximum lethal effects cells. As starting point the development new drug strategies for treatment SCLC, we...
Abstract During skeletal myogenesis, muscle‐regulatory factors bHLH and MEF2 promote the expression of muscle‐specific genes by recruiting several chromatin‐modifying complexes on specific DNA regulatory sequences. A number MyoD‐interacting proteins have been reported, but whether they are recruited to chromatin myogenic loci, relationship with other bound is unknown. We show that MyoD recruits cdk9/cyclin T2, together histone acetyltransferases p300 PCAF, remodeling complex SWI/SNF,...
The cdc2-family of serine/threonine kinases and their binding partners recently were implicated in developmental roles. We previously cloned a cdc2-related kinase, cdk9/PITALRE, that is able to phosphorylate the retinoblastoma protein vitro. describe here cloning characterization mouse homolog cdk9/PITALRE. murine cDNA 98% identical with humans expressed at high levels brain kidney tissues. kinase activity expression cdk9/PITALRE highest terminally differentiated tissues such as muscle...