A5060652405- Congenital gastrointestinal and neural anomalies
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Muscle Physiology and Disorders
- Congenital Diaphragmatic Hernia Studies
- Liver Disease and Transplantation
- Ureteral procedures and complications
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Congenital Anomalies and Fetal Surgery
- Esophageal and GI Pathology
- Neonatal Respiratory Health Research
- Urinary Bladder and Prostate Research
- Histone Deacetylase Inhibitors Research
- Renal and related cancers
- Diet, Metabolism, and Disease
- Gastrointestinal disorders and treatments
- Pelvic floor disorders treatments
- Tracheal and airway disorders
- Ubiquitin and proteasome pathways
- Congenital heart defects research
- Adipose Tissue and Metabolism
- Cancer-related Molecular Pathways
Virginia Commonwealth University Medical Center
2006-2025
Hunter Holmes McGuire VA Medical Center
2014-2025
Virginia Commonwealth University
2014-2025
Sanford Burnham Prebys Medical Discovery Institute
2015-2024
University College Dublin
2015-2024
Discovery Institute
2015-2024
Amity University
2024
Veterans Health Administration
2023
University Health System
2006-2022
Children's Health Ireland at Crumlin
2012-2021
Abstract The spectrum of nonalcoholic fatty liver disease (NAFLD) includes a (NAFL) and steatohepatitis (NASH). specific types amounts lipids that accumulate in NAFLD are not fully defined. free acid (FFA), diacylglycerol (DAG), triacylglycerol (TAG), cholesterol (FC), ester, phospholipid contents normal livers were quantified compared to those NAFL NASH, the distribution acids within these classes was across groups. Hepatic by capillary gas chromatography. mean (nmol/g tissue) DAG...
The expression of microRNA in nonalcoholic steatohepatitis (NASH) and their role the genesis NASH are not known. aims this study were to: (1) identify differentially expressed microRNAs human NASH, (2) tabulate potential targets, (3) define effect a specific microRNA, miR-122, on its targets compare these effects with pattern NASH. 474 was compared subjects metabolic syndrome versus controls normal liver histology. Differentially identified by muParaflo microarray assay validated using...
Specific alterations in hepatic lipid composition characterize the spectrum of nonalcoholic fatty liver disease (NAFLD), which extends from (NAFL) to steatohepatitis (NASH). However, plasma lipidome NAFLD and whether NASH has a distinct lipidomic signature are unknown. A comprehensive analysis lipids eicosanoid metabolites quantified by mass spectrometry was performed NAFL (n = 25) 50) subjects compared with lean normal controls 50). The key findings include significantly increased total...
The extracellular signals which regulate the myogenic program are transduced to nucleus by mitogen-activated protein kinases (MAPKs). We have investigated role of two MAPKs, p38 and signal-regulated kinase (ERK), whose activities undergo significant changes during muscle differentiation. is rapidly activated in myocytes induced differentiate. This activation differs from those triggered stress cytokines, because it not linked Jun–N-terminal stimulation maintained whole process myotube...
Thirteen girls with grade III-V vesicoureteric reflux were treated by endoscopic injection of Teflon paste behind the intravesical ureter. Fourteen 18 ureters showed complete absence after one Teflon. Three required a second for successful treatment reflux. One ureter IV was converted to II Properly carried out, this procedure corrects It takes less than 15 minutes, may be done as day procedure, and avoids open surgery. There have been no complications.
The histologic spectrum of nonalcoholic fatty liver disease (NAFLD) includes (NAFL) and steatohepatitis (NASH), which can progress to cirrhosis in up 20% NASH patients. Bile acids (BA) are linked the pathogenesis therapy NASH. We (1) characterized plasma BA profile biopsy‐proven NAFL compared controls (2) related features, activity, fibrosis. Liquid chromatography/mass spectrometry quantified BAs. Descriptive statistics, paired multiple group comparisons, regression analyses were performed....
OBJECTIVES: Cirrhosis and hepatic encephalopathy (HE) can adversely affect survival, but their effect on socioeconomic emotional burden the family is not clear. The aim was to study of cirrhosis HE patients informal caregivers. METHODS: A cross-sectional in two transplant centers (Veterans University) cirrhotic caregivers performed. Demographics for patient/caregivers, model-for-end-stage liver disease (MELD) score, complications were recorded. Patients underwent a cognitive battery,...
Summary Background Safety of individual probiotic strains approved under Investigational New Drug ( IND ) policies in cirrhosis with minimal hepatic encephalopathy MHE is not clear. Aim The primary aim this phase I study was to evaluate the safety, tolerability Lactobacillus GG LGG compared placebo, while secondary ones were explore its mechanism action using cognitive, microbiome, metabolome and endotoxin analysis patients. Methods Cirrhotic patients randomised 1:1 into or placebo BID after...
Hepatic encephalopathy (HE) can cause major morbidity despite standard of care (SOC; rifaximin/lactulose). Fecal microbial transplant (FMT) enemas postantibiotics are safe, but the effect FMT without antibiotics using capsular route requires investigation. The aim this work was to determine safety, tolerability, and impact on mucosal/stool microbiota brain function in HE after a randomized, single‐blind, placebo‐controlled clinical trial Virginia. Patients with cirrhosis recurrent MELD...
Minimal hepatic encephalopathy (MHE) detection is difficult because of the unavailability short screening tools. Therefore, MHE patients can remain undiagnosed and untreated. The aim this study was to use a Stroop smartphone application (app) (EncephalApp_Stroop) screen for MHE. app standard psychometric tests (SPTs; 2 4 abnormal MHE, gold standard), score (PHES), inhibitory control (ICTs) were administered with cirrhosis (with or without previous overt encephalopathy; OHE) age-matched...
Abstract Fibro-adipogenic progenitors (FAPs) are currently defined by their anatomical position, expression of non-specific membrane-associated proteins, and ability to adopt multiple lineages in vitro. Gene analysis at single-cell level reveals that FAPs undergo dynamic transitions through a spectrum cell states can be identified differential levels Tie2 Vcam1. Different patterns Vcam1-negative high or low /Vcam1-expressing detected during neonatal myogenesis, response acute injury Duchenne...
Abstract Background and Aims Bile acids are hepatic metabolites have many properties considered to be relevant the pathophysiology of NAFLD. Circulating levels intestinal microbiome‐modified bile acid deoxycholate increased in cirrhosis. Approach Results To further elucidate role microbiota linked progressively severe NAFLD, a multiomic study feces including 16S rRNA sequencing, microbial transcriptomics metabolomics was performed cohort with varying phenotypes Several origin derived from...