A5056997652- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Ocular Diseases and Behçet’s Syndrome
- Gastrointestinal motility and disorders
- Retinal Diseases and Treatments
- Liver Disease and Transplantation
- HIV Research and Treatment
- Diet, Metabolism, and Disease
- Asthma and respiratory diseases
- Liver Diseases and Immunity
- Retinal and Optic Conditions
- Diet and metabolism studies
- Lipid metabolism and disorders
- HIV-related health complications and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Complementary and Alternative Medicine Studies
- Neonatal Respiratory Health Research
- Pathogenesis and Treatment of Hiccups
- Herpesvirus Infections and Treatments
- Pancreatitis Pathology and Treatment
- Retinal Imaging and Analysis
- Allergic Rhinitis and Sensitization
Johns Hopkins University
2015-2024
Temple University
2018
Groupe d'Étude Thérapeutique des Affections Inflammatoires du Tube Digestif
2018
Lurie Children's Hospital
2017
Brigham and Women's Hospital
2000-2016
Harvard University
2016
Bloomberg (United States)
2015
Chinese University of Hong Kong
2015
Houston Methodist
2015
AbbVie (United States)
2015
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence of a history significant alcohol use or other known disease. steatohepatitis (NASH) progressive form NAFLD. The Pathology Committee NASH Clinical Research Network designed and validated histological feature scoring system that addresses full spectrum lesions NAFLD proposed activity score (NAS) for clinical trials. comprised 14 features, 4 which were evaluated semi-quantitatively: (0-3), lobular...
Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there no established treatment for this disease.
Antiinflammatory therapies, such as inhaled corticosteroids or nedocromil, are recommended for children with asthma, although there is limited information on their long-term use.We randomly assigned 1041 from 5 through 12 years of age mild-to-moderate asthma to receive 200 microg budesonide (311 children), 8 mg nedocromil (312 placebo (418 children) twice daily. We treated the participants four six years. All used albuterol symptoms.There was no significant difference between either...
The prognoses with respect to mortality and hepatic nonhepatic outcomes across the histologic spectrum of nonalcoholic fatty liver disease (NAFLD) are not well defined.
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. subset of HIV-infected receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal CD4+ T cell counts. The immunologic clinical characteristics phenotype remain undefined. Using data from four distinct cohorts three trials, we show that a during otherwise ART (after CD4 count recovery above 500 cells/mm3) number immunological...
Tracking longitudinal measurements of growth and decline in lung function patients with persistent childhood asthma may reveal links between subsequent chronic airflow obstruction.
Abstract The Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) was formed to conduct multicenter studies on the etiology, contributing factors, natural history, and treatment of nonalcoholic steatohepatitis (NASH). aim this study determine associations readily available demographic, clinical, laboratory variables with diagnosis NASH its key histological features, ability these predict severity fatty liver disease (NAFLD). A total 1266 adults were enrolled in CRN between...
Background. While inflammation predicts mortality in treated human immunodeficiency virus (HIV) infection, the prognostic significance of gut barrier dysfunction and phenotypic T-cell markers remains unclear. Methods. We assessed immunologic predictors a case-control study within Longitudinal Study Ocular Complications AIDS (LSOCA), using conditional logistic regression. Sixty-four case patients who died 12 months treatment-mediated viral suppression were each matched to 2 control...
Journal Article Age- and Sex-specific Incidence Rates of Migraine with without Visual Aura Get access Walter F. Stewart, Stewart 1Department Epidemiology, The Johns Hopkins University School Hygiene Public HealthBaltimore, MD Reprint requests to Dr. Department Health, 615 N wolfe Street, Baltimore, 21205. Search for other works by this author on: Oxford Academic PubMed Google Scholar Martha S. Linet, Linet 2Analytic Studies Section, Biostatistics Branch, epidemiology Program, Division Cancer...
The use of inhaled glucocorticoids for persistent asthma causes a temporary reduction in growth velocity prepubertal children. resulting decrease attained height 1 to 4 years after the initiation is thought not adult height.
Vibration‐controlled transient elastography estimates liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), which are noninvasive assessments of hepatic fibrosis steatosis, respectively. However, prior vibration‐controlled studies reported high failure rates in patients with nonalcoholic fatty disease. We examined the performance characteristics FibroScan 502 Touch two probes, medium (M+) extra large (XL+), disease a multicenter setting. A total 1,696 exams were...
To evaluate the effect of a room high-efficiency particulate air (HEPA) cleaner on cat-induced asthma and rhinitis, 35 cat-allergic subjects who were living with one or more cats studied in double-blind, placebo controlled trial. After 1 mo baseline period, subjects' bedrooms equipped an active for following 3 mo. Evaluations included monthly measurement cat-allergen levels, daily morning, afternoon, nighttime nasal- chest-symptom scores, twice-daily peak-flow rates, medication spirometry,...
Factors associated with mortality were examined for 27,370 hip fracture patients aged 65 years or older in Maryland hospitals, using discharge data 1979–1988. Variables of interest included sociodemography, principal medical and injury diagnoses, E-code, year, disposition, hospital. For both white males females, the rate doubled each 5–year increment age. The overall proportion who died during hospitalization was 4.9% (n = 1,339). After multivariate adjustment, there remained a substantially...
OBJECTIVE. Systemic corticosteroids are known to induce osteoporosis and increase the risk for fractures in adults children. Inhaled have been shown at risk; however, long-term prospective studies of children assess risks multiple short courses oral chronic inhaled not performed. Thus, we assessed effects on bone mineral accretion over a period years. METHODS. This was cohort follow-up study median 7 years who had mild-to-moderate asthma initially were randomly assigned into Childhood Asthma...
Summary Background Non‐alcoholic steatohepatitis ( NASH ) is a common cause of serum alanine aminotransferase ALT elevations and chronic liver disease, but it unclear how well reflect the injury. Aim To assess changes in improvements histology response to vitamin E therapy. Methods The placebo arms Pi oglitazone vs. V itamin Placebo N on‐alcoholic S teatohepatitis PIVENS trial were reassessed for associations among levels, body weight histology. An was defined as decrease ≤40 U/L by ≥30%...