Jean P. Molleston
A5038339390- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Cystic Fibrosis Research Advances
- Hepatitis B Virus Studies
- Congenital Anomalies and Fetal Surgery
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Intestinal Malrotation and Obstruction Disorders
- Eosinophilic Esophagitis
- Folate and B Vitamins Research
- Gastroesophageal reflux and treatments
- Childhood Cancer Survivors' Quality of Life
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Metabolism and Genetic Disorders
- Pancreatitis Pathology and Treatment
- Genetic and Kidney Cyst Diseases
- Neonatal Health and Biochemistry
- Gastrointestinal Bleeding Diagnosis and Treatment
- Lipid metabolism and disorders
Riley Hospital for Children
2016-2025
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University Health
2016-2025
Indiana University School of Medicine
2015-2024
Indiana University
2005-2024
University of Colorado Denver
2017-2022
Cincinnati Children's Hospital Medical Center
2006-2022
Manpower Demonstration Research Corporation
2022
University of Michigan–Ann Arbor
2022
Lurie Children's Hospital
1998-2022
Cholestatic jaundice in infancy affects approximately 1 every 2500 term infants and is infrequently recognized by primary providers the setting of physiologic jaundice. always pathologic indicates hepatobiliary dysfunction. Early detection care physician timely referrals to pediatric gastroenterologist/hepatologist are important contributors optimal treatment prognosis. The most common causes cholestatic first months life biliary atresia (25%-40%) followed an expanding list monogenic...
Adult nonalcoholic fatty liver disease (NAFLD) is characterized by absent or mild portal chronic inflammation (CI); in children, CI may be predominant. This study correlated clinical features with CI. Centrally-graded biopsies and temporally-related parameters from 728 adults 205 children. From the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) were evaluated. Mild, more than no found 60%, 23% 16% of adult 76%, 14% 10% pediatric biopsies. Autoantibodies, elevated alanine...
Nonalcoholic steatohepatitis, in which fatty change and inflammation of the liver occur absence excess alcohol intake, is increasingly recognized obese children. Although fibrosis common pediatric nonalcoholic cirrhosis has been reported rarely. The two boys here developed from steatohepatitis at ages 10 14 yr. One child progressed to with symptomatic portal hypertension within a 2-yr period.
There is relatively little information in the literature on histopathology of chronic hepatitis C children. The Peds-C Trial, designed to test efficacy and safety peginterferon alfa-2a ribavirin children, provided an opportunity examine liver biopsies from 121 treatment-naïve ages 2 16 (mean, 9.8 years) infected with virus (HCV) no other identifiable cause for disease, signs hepatic decompensation, or another significant nonhepatic disease. Liver were scored inflammation, fibrosis,...
Biliary atresia is the most common cause of end-stage liver disease in children. Controversy exists as to whether use steroids after hepatoportoenterostomy improves clinical outcome.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic in United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate burden illness NAFLD. aim was report QOL scores adults with examine severity QOL. were collected from enrolled Steatohepatitis Clinical Research Network using Short Form 36 (SF-36) survey, compared normative U.S. population scores. Liver biopsy histology reviewed by a central pathology committee. A...
The etiology of biliary atresia (BA) is unknown. Given that patterns anomalies might provide etiopathogenetic clues, we used data from the North American Childhood Liver Disease Research and Education Network to analyze in infants with BA. In all, 289 who were enrolled prospective database prior surgery at any 15 participating centers evaluated. Group 1 was nonsyndromic, isolated BA (without major malformations) (n = 242, 84%), 2 least one malformation considered as defined by National Birth...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic in children United States. Although changes diet are often recommended to improve NAFLD, little known regarding influence of on histologic features disease.This was a prospective, cross-sectional registry-based study. Children (n = 149) enrolled multicenter nonalcoholic steatohepatitis (NASH) Clinical Research Network had demographic, anthropometric, clinical, laboratory, and histology data obtained, including Block Brief...
Abstract Medically refractory, severe, cholestasis‐induced pruritus in Alagille syndrome may be improved by surgical interruption of the enterohepatic circulation. This multicenter trial (NCT02057692) tested hypothesis that intestinal bile acid transport inhibitor maralixibat would similarly reduce syndrome. Thirty‐seven children with were randomly assigned to double‐blinded administration placebo, 70, 140, or 280 µg/kg/day for 13 weeks. Pruritus was assessed caregiver (itch‐reported outcome...
Background and Aims: High levels of serum matrix metalloproteinase-7 (MMP-7) have been linked to biliary atresia (BA), with wide variation in concentration cutoffs. We investigated the accuracy MMP-7 as a diagnostic biomarker large North American cohort. Approach Results: was measured samples 399 infants cholestasis Prospective Database Infants Cholestasis study Childhood Liver Disease Research Network, 201 BA 198 non-BA (age median: 64 59 days, p = 0.94). assayed on antibody-bead...
Abstract Chronic hepatitis C virus (HCV) infection is usually asymptomatic in children, but significant liver disease may occur. We evaluated the efficacy, safety, and pharmacokinetics of interferon alfa-2b ribavirin children with chronic HCV. determined optimal dose an initial cohort a phase 1 study then subsequently used it, combination alfa-2b, second this 3 trial. The primary efficacy endpoint all studies was sustained virological response, defined by undetectable serum HCV RNA 24 weeks...
To assess the role of esophagogastroduodenoscopy in evaluation children with suspected inflammatory bowel disease.All disease who underwent during their initial at our institution a 7-year period (December 1993 to November 2000) were included study.The study 115 patients: 81 Crohn (mean age, 11.34 years; 42 males) and 34 ulcerative colitis 11.79 20 males). Abnormal findings on noted 64% patients 50% colitis; histologic abnormalities found 81.6% 70.6% patients, respectively. Granulomas upper...
ABSTRACT Objective: Hepatitis C virus (HCV) infection is associated with decreased quality of life (QOL) and neurocognitive dysfunction in adults, but little known about its impact on children their caregivers. Patients Methods: We studied the QOL, behavioral, emotional, cognitive functioning 114 treatment‐naïve HCV enrolled a placebo‐controlled, randomized, multisite clinical trial evaluating peginterferon α‐2a alone or ribavirin. Baseline assessment included measures children's...