A5101479633- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Eating Disorders and Behaviors
- Liver Disease Diagnosis and Treatment
- Global Health and Surgery
- Gallbladder and Bile Duct Disorders
- Liver Diseases and Immunity
- Obesity, Physical Activity, Diet
- Childhood Cancer Survivors' Quality of Life
- Global Health Workforce Issues
- Congenital Anomalies and Fetal Surgery
- Adolescent and Pediatric Healthcare
- Organ Transplantation Techniques and Outcomes
- Travel-related health issues
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Genetic and Kidney Cyst Diseases
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Child Nutrition and Feeding Issues
- Asthma and respiratory diseases
- Global Maternal and Child Health
- Patient-Provider Communication in Healthcare
University of New Mexico
2008-2025
New Mexico VA Health Care System
2008-2025
Oregon Health & Science University
2019-2024
Wuhan University
2024
Doernbecher Children's Hospital
2020-2024
Prince of Wales Hospital
2020-2022
UNSW Sydney
2021-2022
University of Pennsylvania
2011-2020
Children's Hospital of Philadelphia
2011-2019
Philadelphia University
2016-2019
Congestive hepatopathy is a recognized complication of Fontan physiology. Data regarding the incidence and risk factors are lacking.Liver biopsies cardiac catherizations were performed as part an evaluation offered to all patients ≥10 years after Fontan. Quantitative determination hepatic fibrosis was using Sirius red staining with automated calculation collagen deposition per slide (%CD). Biopsies from included subjects compared stained specimens controls without known fibrotic liver...
Increasing demand for global health education in medical training has driven the growth of educational programs predicated on a model short-term service abroad. Almost two-thirds matriculating students expect to participate experience during school, continuing into residency and early careers. Despite positive intent, such experiences (STEGHs) may exacerbate inequities even cause harm. Growing out "medical missions" tradition, contemporary participation continues evolve. Ethical concerns...
Background and Aims: Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, real‐world lacking. This study aimed to elucidate the natural history of liver disease in contemporary, international cohort children with ALGS. Approach Results: was multicenter retrospective clinically and/or genetically confirmed ALGS diagnosis, born between January 1997 August 2019. Native survival (NLS) event‐free rates...
Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are generally asymptomatic or have mild symptoms low rates of hospitalization (<2%) and death (<0.03%).1 After initial infection, some children, including those who experienced disease, develop other postacute manifestations COVID, multisystem inflammatory in children (MIS-C, not discussed this statement) sequelae SARS-CoV-2 infection. The latter post-COVID condition may be known as long long-haul COVID-19,...
Background and Aims: Alagille syndrome (ALGS) is characterized by chronic cholestasis with associated pruritus extrahepatic anomalies. Maralixibat, an ileal bile acid transporter inhibitor, approved pharmacologic therapy for cholestatic in ALGS. Since long-term placebo-controlled studies are not feasible or ethical children rare diseases, a novel approach was taken comparing 6-year outcomes from maralixibat trials aligned harmonized natural history cohort the G lobal AL agille A lliance...
Food reinforcement is cross-sectionally related to BMI and energy intake in adults, prospectively predicts weight gain children, but there has not been any research studying food as a predictor of adult gain.This study examined whether the relative reinforcing value versus sedentary activities, measured on progressive ratio schedule, 12-month sample 115 nonobese (BMI < 30) adults. Dietary disinhibition dietary restraint were also potential moderators this relationship.In hierarchical...
Contemporary interest in short-term experiences global health (STEGH) has led to important questions of ethics, responsibility, and potential harms receiving communities. In addressing these issues, the role local engagement through partnerships between external STEGH facilitating organization(s) internal community been identified as crucial mitigating pitfalls. This perspective piece offers a framework categorize different models based on professional review existing literature. will...
Mitochondrial DNA (mtDNA) maintenance defects are a group of diseases caused by deficiency proteins involved in mtDNA synthesis, mitochondrial nucleotide supply, or dynamics. One the is MPV17, which inner membrane protein importing deoxynucleotides into mitochondria. In 2006, pathogenic variants MPV17 were first reported to cause infantile-onset hepatocerebral depletion syndrome and Navajo neurohepatopathy. To date, 75 individuals with MPV17-related defect have been 39 different variants....
Interactions between bacteriophages with mammalian immune cells are of great interest and most phages possess at least one molecular pattern (nucleic acid, sugar residue, or protein structure) that is recognizable to the system through pathogen associated (PAMP) receptors (i.e., TLRs). Given reside in same body niches as bacteria, they share propensity stimulate quench responses depending on nature their interactions host cells. While vitro research focuses outcomes direct application...
Study impact of F-18 FDG PET/CT on initial staging, restaging, and evaluating treatment response (ETR) in bone soft tissue sarcomas (BSTS), focusing discrepancy between CT PET portions.Ninety-three BSTS patients having 204 studies were retrospectively reviewed. They divided into 4 groups. Group I for staging included 16 patient studies. The other 3 groups according to the time interval from last received. II ETR up 2 months 83 III was early restaging after 6 45 IV long-term follow-up 60 All...
The relative reinforcing value of food (RRV(food)) is positively associated with energy consumed and overweight status. One hypothesis relating these variables that reinforcement related to BMI through usual intake. Using a sample two hundred fifty-two adults varying weight levels, results showed intake mediated the relationship between RRV(food) (estimated indirect effect = 0.0027, bootstrapped 95% confidence intervals (CIs) 0.0002-0.0068, ratio 0.34), controlling for age, sex, minority...
Increasing demand for Short-term Experiences in Global Health (STEGH), particularly among medical trainees, has seen a growth programming that brings participants from high-income countries to low and middle-income settings order engage service, teaching or research activities. Historically the domain of faith-based organizations conducting "missions", STEGH are now offered by diverse groups including academic institutions, non-profit organizations, private sector, either as dedicated...