René Romero
A5072945397- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Congenital Heart Disease Studies
- Transplantation: Methods and Outcomes
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Clinical Nutrition and Gastroenterology
- Hepatitis C virus research
- Childhood Cancer Survivors' Quality of Life
- Liver Diseases and Immunity
- Renal Transplantation Outcomes and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Mitochondrial Function and Pathology
- Folate and B Vitamins Research
- Organ Donation and Transplantation
- Hepatitis B Virus Studies
- Family and Disability Support Research
- Drug Transport and Resistance Mechanisms
- Family Support in Illness
- Drug-Induced Hepatotoxicity and Protection
- Cytomegalovirus and herpesvirus research
Massachusetts General Hospital
1993-2025
Emory University
2015-2024
Children's Healthcare of Atlanta
2015-2024
University of North Carolina at Chapel Hill
2024
Duke University
2024
Harvard University
1993-2024
E Ink (South Korea)
2022
Creative Commons
2018
Center for Cancer and Blood Disorders
2017
University of California, San Francisco
2015
This practice guideline has been approved by the American Association for Study of Liver Diseases, Society Transplantation and North Pediatric Gastroenterology, Hepatology Nutrition. Current Diseases (AASLD) liver transplant evaluation guidelines include both adult pediatric patients.1 While transplants account ∼7.8% all in United States, sufficient differences between patients seeking transplantation (LT) now require independent, yet complementary documents. document will focus on issues at...
Biliary atresia is the most common cause of end-stage liver disease in children. Controversy exists as to whether use steroids after hepatoportoenterostomy improves clinical outcome.
N-acetylcysteine (NAC) was found to improve transplantation-free survival in only those adults with nonacetaminophen (non-APAP) acute liver failure (ALF) and grade 1-2 hepatic encephalopathy (HE). Because non-APAP ALF differs significantly between children adults, the Pediatric Acute Liver Failure (PALF) Study Group evaluated NAC PALF. Children from birth through age 17 years enrolled PALF registry were eligible enter an adaptively allocated, doubly masked, placebo-controlled trial using a...
The etiology of biliary atresia (BA) is unknown. Given that patterns anomalies might provide etiopathogenetic clues, we used data from the North American Childhood Liver Disease Research and Education Network to analyze in infants with BA. In all, 289 who were enrolled prospective database prior surgery at any 15 participating centers evaluated. Group 1 was nonsyndromic, isolated BA (without major malformations) (n = 242, 84%), 2 least one malformation considered as defined by National Birth...
Background and Aims: Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, real‐world lacking. This study aimed to elucidate the natural history of liver disease in contemporary, international cohort children with ALGS. Approach Results: was multicenter retrospective clinically and/or genetically confirmed ALGS diagnosis, born between January 1997 August 2019. Native survival (NLS) event‐free rates...
ABSTRACT Objective: Biliary atresia (BA) frequently results in portal hypertension (PHT), complications of which lead to significant morbidity and mortality. The Childhood Liver Disease Research Education Network was used perform a cross‐sectional multicentered analysis PHT children with BA. Methods: Subjects BA receiving medical management at site were enrolled. A priori, clinically evident defined as “definite” when there either history complication or clinical findings consistent (both...
Arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome is a rare autosomal recessive multisystem disorder caused by mutations in vacuolar protein sorting 33 homologue B (VPS33B) and VPS33B interacting protein, apical-basolateral polarity regulator (VIPAR). Cardinal features of ARC include congenital joint contractures, renal tubular dysfunction, cholestasis, severe failure to thrive, ichthyosis, defect platelet alpha-granule biogenesis. Most patients with do not survive past the first...
Alagille syndrome (ALGS) is an autosomal dominant multisystem disorder with cholestasis as a defining clinical feature. We sought to characterize hepatic outcomes in molecularly defined cohort of children ALGS-related cholestasis. Two hundred and ninety-three participants ALGS native liver were enrolled. Participants entered the study at different ages data collected retrospectively prior enrollment, prospectively during course. Genetic analysis 206 revealed
Background and Aims: Alagille syndrome (ALGS) is characterized by chronic cholestasis with associated pruritus extrahepatic anomalies. Maralixibat, an ileal bile acid transporter inhibitor, approved pharmacologic therapy for cholestatic in ALGS. Since long-term placebo-controlled studies are not feasible or ethical children rare diseases, a novel approach was taken comparing 6-year outcomes from maralixibat trials aligned harmonized natural history cohort the G lobal AL agille A lliance...
The safety and efficacy of sofosbuvir-velpatasvir in children aged 3-17 years with chronic hepatitis C virus (HCV) infection any genotype were evaluated.
Mitochondrial hepatopathies (MHs) are primary mitochondrial genetic disorders that can present as childhood liver disease. No recognized biomarkers discriminate MH from other diseases. The protein growth differentiation factor 15 (GDF15) and fibroblast 21 (FGF21) differentiate myopathies myopathies. We evaluated these to determine if they diseases in children.
PREAMBLE Current American Association for the Study of Liver Diseases (AASLD) liver transplant evaluation guidelines include both adult and pediatric patients (1). While transplants account ∼7.8% all in United States, sufficient differences between seeking transplantation (LT) now require independent, yet complementary documents. This document will focus on issues at each level process. Disease categories suitable referral to a LT program are similar adults: acute failure (ALF), autoimmune,...
Racial and socioeconomic disparities exist in liver transplantation (LT) outcomes among adults, but little research exists for pediatric LT populations. We examined racial differences graft survival mortality within a retrospective cohort of young adult recipients at large children's transplant center the Southeast between 1998 2011. The association race/ethnicity rates failure was with Cox proportional hazards models that were adjusted demographic clinical factors as well individual-level...
Pulse oximetry (SpO2) is the most reliable and inexpensive noninvasive method of continuous monitoring blood oxygenation. SpO2 also has become an important tool newborn in delivery room. However there are several questions regarding expected normal values infant room (1). Recently, Dawson et al (2) published reference babies who did not require supplemental oxygen It was noted that: 1) probe takes 1–2 mins to pick up signal; 2) initial saturation levels very low, range 50%–60%; 3) it on...
α-1-Antitrypsin (A1AT) deficiency is a common genetic disease with an unpredictable and highly variable course. The Childhood Liver Disease Research Education Network National Institutes of Health, multicenter, longitudinal consortium studying pediatric liver diseases, the objective prospectively defining natural history identifying modifiers.