A5067934543- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Hepatitis C virus research
- Neonatal Health and Biochemistry
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Marriage and Sexual Relationships
- Clinical Nutrition and Gastroenterology
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Intestinal Malrotation and Obstruction Disorders
- Child and Adolescent Health
- Liver Diseases and Immunity
- Child Nutrition and Feeding Issues
- Hepatitis Viruses Studies and Epidemiology
- Diet and metabolism studies
- Viral gastroenteritis research and epidemiology
- Pharmacological Effects and Toxicity Studies
- Health Sciences Research and Education
- Renal Transplantation Outcomes and Treatments
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati Medical Center
2000-2024
University of Cincinnati
2006-2023
Boston Children's Hospital
1990-2022
Albert Einstein College of Medicine
1984-2022
Comer Children's Hospital
1991-2022
SUNY Upstate Medical University
2019-2022
St. Christopher's Hospital for Children
2019-2022
Children's Hospital of Richmond at VCU
2019-2022
Children's National
2019-2022
Abstract Diets high in saturated fat and fructose have been implicated the development of obesity nonalcoholic steatohepatitis (NASH) humans. We hypothesized that mice exposed to a similar diet would develop NASH with fibrosis associated increased hepatic oxidative stress be further reflected by plasma levels respiratory chain component, oxidized coenzyme Q9 (oxCoQ9). Adult male C57Bl/6 were randomly assigned chow, high-fat (HF), or high-carbohydrate (HFHC) diets for 16 weeks. The chow HF...
No all-oral, direct-acting antiviral regimens have been approved for children with chronic hepatitis C virus (HCV) infection. We conducted a phase 2, multicenter, open-label study to evaluate the efficacy and safety of ledipasvir-sofosbuvir in adolescents HCV genotype 1 One hundred patients aged 12-17 years received combination tablet 90 mg ledipasvir 400 sofosbuvir once daily 12 weeks. On tenth day following initiation dosing, 10 underwent an intensive pharmacokinetic evaluation...
A new inborn error in bile acid synthesis, manifest identical infant twins as severe intrahepatic cholestasis, is described involving the delta 4-3-oxosteroid 5 beta-reductase catalyzed conversion of key intermediates, 7 alpha-hydroxy-4-cholesten-3-one and alpha,12 alpha-dihydroxy-4-cholesten-3-one for chenodeoxycholic cholic to respective 3 alpha-hydroxy-5 beta (H) products. This defect was detected by fast atom bombardment ionization-mass spectrometry from an elevated excretion...
NEONATAL biliary atresia was originally thought to be a developmental malformation. However, microscopical examination of bile ducts resected during portoenterostomy has revealed inflammatory lesions suggesting an ongoing postnatal process such as infection.1 , 2 Viral isolation and serologic studies have usually been negative except for occasional case associated with cytomegalovirus or congenital rubella infection.3 4 5 6 Our interest in reovirus type 3 (reo-3) potential cause stimulated...
There is relatively little information in the literature on histopathology of chronic hepatitis C children. The Peds-C Trial, designed to test efficacy and safety peginterferon alfa-2a ribavirin children, provided an opportunity examine liver biopsies from 121 treatment-naïve ages 2 16 (mean, 9.8 years) infected with virus (HCV) no other identifiable cause for disease, signs hepatic decompensation, or another significant nonhepatic disease. Liver were scored inflammation, fibrosis,...
We studied serum vitamin E levels and the ratio of to lipid in 11 children with chronic cholestasis complicated by deficiency, as defined characteristic neurologic signs or sural-nerve histopathology addition impaired intestinal absorption E. Eight had low E, well ratios total lipids cholesterol. However, three patients normal but (two cholesterol). In four who were not E-deficient, all values normal. conclude that deficiency may exist a child concentration is most reliable biochemical index...
SODIUM valproate, a recently introduced anticonvulsant, is particularly useful in the management of absence seizures and has gained widespread popularity.1 Initial European studies reported infrequ...
Surgical interposition of distal ileum into the proximal jejunum is a bariatric procedure that improves metabolic syndrome. Changes in intestinal and hepatic physiology after ileal (transposition) surgery (IIS) are not well understood. Our aim was to elucidate adaptation interposed ileum, which we hypothesized, would lead early bile acid reabsorption thus short circuiting enterohepatic recycling more bowel segments. Rats with diet-induced obesity were randomized IIS, 10 cm repositioned...
Children with chronic hepatitis C virus infection have limited treatment options. We evaluated the all-oral combination of sofosbuvir and ribavirin in adolescents aged 12-17 genotype 2 or 3 (ClinicalTrials.gov NCT02175758). Fifty-two patients received 400 mg once daily weight-based twice for 12 (genotype 2) 24 3) weeks. The pharmacokinetics its metabolite GS-331007 were by intensive plasma sampling at day 7 first 10 enrolled sparse all throughout treatment. primary efficacy endpoint was...
Currently, there are no interferon-free treatments available for hepatitis C virus (HCV)-infected patients younger than 12 years. We evaluated the safety and effectiveness of all-oral regimen ledipasvir-sofosbuvir ± ribavirin in HCV-infected children aged 6 to <12 In an open-label study, years received ledipasvir 45 mg-sofosbuvir 200 mg as two fixed-dose combination tablets 22.5/100 once daily, with or without ribavirin, 24 weeks, depending on HCV genotype cirrhosis status. The primary...
For children under 12 years of age who have chronic hepatitis C virus (HCV) infection, there are currently no approved treatments with direct-acting antiviral agents. We therefore evaluated the safety and efficacy ledipasvir-sofosbuvir in HCV-infected aged 3 to <6 years. In an open-label study, patients old chronically infected HCV genotype 1 (n = 33) or 4 1) received weight-based doses combined as granules (33.75 mg/150 mg for weights <17 kg 45 mg/200 ≥17 kg) weeks. The primary endpoint was...
We studied the effect of long-term correction vitamin E deficiency on neurologic function in 14 children with chronic cholestasis. Vitamin repletion was achieved all, either by large oral doses (up to 120 IU per kilogram body weight day) or intramuscular administration dl-alpha-tocopherol (0.8 2.0 day). With early institution therapy, remained normal two asymptomatic below age three years after 15 and 18 months therapy. Neurologic became symptomatic 32 Restitution more limited nine 5 17 1/2...
ABSTRACT Objective: Hepatitis C virus (HCV) infection is associated with decreased quality of life (QOL) and neurocognitive dysfunction in adults, but little known about its impact on children their caregivers. Patients Methods: We studied the QOL, behavioral, emotional, cognitive functioning 114 treatment‐naïve HCV enrolled a placebo‐controlled, randomized, multisite clinical trial evaluating peginterferon α‐2a alone or ribavirin. Baseline assessment included measures children's...